“…It is worth noting that the Table 3 Log P values and water solubility results of aporphine alkaloids and 4R-hydroxyaporphine alkaloids. water solubilities of 1b, 2b, and 3b are 759.5 ± 36.2, 2154.1 ± 45.2, and 778.8 ± 23.7 mg/L, respectively, which are unusually higher than those of 1a, 2a, and 3a, as well as other compounds reported in the literature [16,17]. Due to these significant improvements in water solubility and bioactivities, these 4R-hydroxyaporphine alkaloids have potential as water-soluble AChE inhibitors and antitumor agents, particularly 1b and 2b.…”