Antitumor activity studies of iridium (III) polypyridine complexes-loaded liposomes against gastric tumor cell in vitro

A fundamental role of the solvent polarity and remote substitution of the 2-(4-R-phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline framework in controlling the ground- and excited-state properties of Re(i) chromophores [ReCl(CO)3(R-C6H4-imphen)]

“…They have been combined with numerous transition metal ions including Cu( i ), 21–25 Cu( ii ), 26–28 Ru( ii ), 29–40 and Ir( iii ). 41–46 The vast majority of these coordination compounds have potential uses in anticancer therapy, 26–28,31,34–37,39–46 bioimaging, 32,47 the conversion of solar energy, 22,29 organic light-emitting diodes, 21,23,48–50 photoredox catalysis, 38,51,52 and luminescence sensing. 30,38,53–56 Surprisingly, little attention has been paid to Re( i ) carbonyl chromophores with 1 H -imidazo[4,5- f ][1,10]phenanthrolines, 47,49,57–66 in contrast to phenanthroline Re( i ) carbonyl complexes [Re(CO) 3 X(N∩N)] n + ( n = 0 or 1), which have a very rich history in coordination chemistry and largely contribute to the understanding of photophysical and light-induced electron-transfer and electronic energy-transfer processes.…”