Antitumor Activity of Wheats With High Orthophenolic Content

Drankhan, Kelly; Carter, John; Madl, Ronald L.; Klopfenstein, C. F.; Padula, Frank; Lu, Yemen; Warren, Thomas C.; Schmitz, Neil; Takemoto, Dolores J.

doi:10.1207/s15327914nc4702_12

Cited by 46 publications

(33 citation statements)

References 28 publications

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“…Phenolics present in the whole wheat can act as antibiotics or antioxidants. The presence of the orthophenolics in wheat was correlated significantly with tumour inhibition [25]. The metabolism of lignans (di-phenolics found in whole wheat) has been also been correlated with a reduced risk of breast cancer [26].…”

Section: Cancermentioning

confidence: 99%

Review of Nutraceuticals and Functional Properties of Whole Wheat

Poudel¹,

Bhatta²

2017

J Nutr Food Sci

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Wheat (Triticum aestivum L.) is one of the most commonly cultivated and consumed cereals throughout the world. Though phytochemicals and antioxidants in the cereal grains have not been studied as in fruits and vegetables, given the role of wheat in our diet plate, it is a given of primary importance to understand the chemistry of our major food, wheat. The presence of diverse polyphenols and their action against leading cause of death, including heart diseases, cancer, obesity, and diabetes, widens the scope of wheat. Phytochemicals such as phenolic acids, alkylresorcinols, flavonoids, phytosterols, and carotenoids are present in whole wheat. The majority of phytochemicals are located in the wheat bran/germ fraction, and they are the leading contributors to the health promoting activities. However, the presence of anti-nutrients and binding of phenolic acids with protein may have adverse effect on health. This review mainly focuses on studies that have been carried out in the past decade to present, emphasizing the importance of whole wheat and whole wheat based products in preventing major diseases and disease conditions, potentials threats, current lacks, and future prospects.

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Section: Cancermentioning

confidence: 99%

Review of Nutraceuticals and Functional Properties of Whole Wheat

Poudel¹,

Bhatta²

2017

J Nutr Food Sci

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“…Additionally, a study conducted on antitumor activity showed a positive correlation with the orthophenolic content in wheat samples given to Min mice [20]. As a result we investigated the orthophenolic content in juneberries to test for any correlation with the other assays.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Assessment of Chemopreventive Contents of Native American Juneberries ( (Nutt.) Nutt. ex M. Roem.)

Gunawardana¹,

Eberhart²,

Hartman³

et al. 2016

Pharmac. Crops

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Juneberry (Amelanchier alnifolia) is a shrub with edible berry-like fruit commonly found across the Northern Great Plains of North America and widely used by Native Americans as a medicinal plant. This study was an effort to assess the chemopreventive contents of juneberry extracts in ethanol by measuring the total phenolic content, orthophenolic content, DPPH radical scavenging activity, ABTS radical cation decolorization assay, and cytoprotective effects on HepG2 cells. The total phenolic content upon treatment with Folin-Ciocalteu's reagent ranged from 0.2261 ± 0.0031 to 19.311 ± 1.651 mg.g -1 tannic acid equivalents. Orthophenolic content quantified by monitoring the bathochromic shifts upon reacting with sodium molybdate ranged from 0.12 ± 0.03 to 2.38 ± 0.15 mg.g -1 of FW. Antioxidant activity using DPPH assay ranged from 50.08 ± 0.77 to 98.60 ± 1.12%, in contrast to quercetin dihydrate with an activity of 86.20 ± 0.05%. ABTS radical scavenging assay produced inhibition from 1.90 ± 0.11 to 60.25 ± 1.65% as opposed to 6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (Trolox) with an inhibition of 94.03 ± 0.21% . HepG2 cells treated with 100 µg/µL of sample WC2B showed 56% cell-viability against tert-Butyl hydroperoxide in comparison to quercetin dihydrate which showed 90% cytoprotection. Total phenolic content and orthophenolic content in juneberries from 2012 were higher than in juneberries obtained from the 2013 and 2014. Similarly fruit grown in the wild showed significantly higher antioxidant activity and phenolic content than those grown in domestic cultivars.

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“…APC Min mice carry truncated adenomatous polyposis coli (APC) and thus spontaneously develop multiple intestinal neoplasia (Min). Drankhan et al (11) applied this model into tumor prevention by feeding wheat bran and found a significant difference in antitumor activity among various wheat cultivars when the fiber contents were equal. As shown in Table 16.3, we compared the SDG contents in four wheat cultivars with antitumor activities in APC Min mice and found a significant correlation between SDG contents and antitumor activities, suggesting lignans may attribute to the observed colon cancer prevention by wheat bran or whole grain products.…”

Section: Plausible Mechanisms Of Lignans For Cancer Preventionmentioning

confidence: 99%