Antitumor activity of the lipid fraction of the spores of an anaerobic bacterium Clostridium butyricum

Гаенко, Г. П.; Моисеева, Е. В.; Savel’ev, O. Yu.; Molotkovskiĭ, Yu. G.; Водовозова, Е. Л.

doi:10.1134/s0026261709050087

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“Omics” and Other Biological Investigations Suggest A Role F1

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2012

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“…C. butyricum , another common gut resident, produces partially characterized phenolic lipids which may possess antitumor activity [24]. Polyketide biosynthetic genes[25] and lantibiotic biosynthetic genes [26], have also been noted in bifidiobacterium—a predominant species in the gut microbiome.…”

Section: “Omics” and Other Biological Investigations Suggest A Role Fmentioning

confidence: 99%

The bacterial chemical repertoire mediates metabolic exchange within gut microbiomes

Rath

Dorrestein

2012

Current Opinion in Microbiology

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Microbial communities in the gut have been hypothesized to play key roles in the health of the host organism. Exploring the relationship between these populations and disease states has been a focus of the human microbiome project. However, the biological roles of the compounds produced by the gut bacteria are largely unknown. We hypothesize that these compounds act as metabolic exchange factors—mediating inter- and intra- species interactions in the microbiome. This view is supported through this review of known bacterial metabolic exchange factors and evidence for uncharacterized metabolic exchange factors in the gut. The impact of model systems and technological developments in exploring this hypothesis are also discussed. Together, these investigations are revolutionizing our understanding of the gut microbiome—presenting the possibility of identifying new strategies for treating disease in the host.

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Section: “Omics” and Other Biological Investigations Suggest A Role Fmentioning

confidence: 99%

The bacterial chemical repertoire mediates metabolic exchange within gut microbiomes

Rath

Dorrestein

2012

Current Opinion in Microbiology

View full text Add to dashboard Cite

show abstract

Antitumor activity of the lipid fraction of the spores of an anaerobic bacterium Clostridium butyricum

Cited by 1 publication

References 11 publications

The bacterial chemical repertoire mediates metabolic exchange within gut microbiomes

The bacterial chemical repertoire mediates metabolic exchange within gut microbiomes

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