Antitumor activity of Portulaca oleracea L. polysaccharides against cervical carcinoma in vitro and in vivo

Cytotoxicity Assessments of Portulaca oleracea and Petroselinum sativum Seed Extracts on Human Hepatocellular Carcinoma Cells (HepG2)

“…The study demonstrated that 50-500 μg/ml of PO and 100-500 of PS concentrations significantly (p<0.01) decreased the cell viability. Our results are in accordance with the previous studies showing v anticancer activity of PO at 50-500 μg/ml concentrations against the human cervical cancer (HeLa) and the mouse cervical carcinoma (U14) cells (Zhao et al, 2013). The protective potential of PO against Ehrlich ascites carcinoma bearing albino mice have also been reported (Ali et al, 2014).…”

Purification, characterization and biological activity of a novel polysaccharide from Inonotus obliquus

“…These results were different from the other known polysaccharides from Ornithogalum caudatum [22], Chlorella pyrenoidosa [23], Portulaca oleracea L. [24] and G. pentaphyllum [25], all of which could directly inhibit the proliferation of cancer in vitro. However, Our result is in agreement with many other findings.…”

Effects ofPortulaca oleracea L.Polysaccharides on Phenotypic and Functional Maturation of Murine Bone Marrow Derived Dendritic Cells

“…We have previously shown that POL-P3b possesses the activity of inhibiting cervical cancer cell growth in vitro and in vivo in a concentration-and time-dependent manner, and the mechanisms were associated with sub-G1 phase cell cycle arrest, triggering DNA damage and inducing apoptosis. POL-P3b is heteropolysaccharides and has been shown to contain different carbohydrate compositions, with glucose and galactose being the major monosaccharide components (9).…”

“…Portulaca oleracea L. has been used as folk medicine and food nutrient supplements in different countries (4)(5)(6). Portulaca oleracea L. polysaccharide (POL-P3b), the active ingredient extracted from Portulaca oleracea L., has found to have bioactivities including enhancing the body's immune and antitumor activities (7)(8)(9). We have previously shown that POL-P3b possesses the activity of inhibiting cervical cancer cell growth in vitro and in vivo in a concentration-and time-dependent manner, and the mechanisms were associated with sub-G1 phase cell cycle arrest, triggering DNA damage and inducing apoptosis.…”