Antitumor activity of Pd(II) complexes with N,S or O,S coordination modes of acylthiourea ligands

In vitrocytotoxicity and antibacterial activity of [Pd(AMTTO)(PPh3)2]: a novel promising palladium(ii) complex

“…Similar values have also been found in other palladium(II) complexes bearing two cis-disposed triphenylphosphine moieties. 62,[80][81][82] The Pd-N and Pd-S bond distances of 1.996(2) and 2.306(5) Å, respectively, fall in the range observed with other AMTTO-Pd(II) complexes. 63,81,82 The Pd1-P1 bond distance of 2.299(5) Å is slightly longer than the distance of Pd1-P2 of 2.291(5) Å as a consequence of the stronger trans influence of the sulfur atom compared to that of the nitrogen atom.…”

“…The measured coupling constant of 32.1 Hz ( 2 J p-p ) is in the range observed with other palladium(II) complexes containing two cis-positioned triphenylphosphine moieties, cis-[Pd(PPh 3 ) 2 (N,N-diphenyl-N 0 -thiophenylthioureatok 2 O,S)]PF 6 ( 2 J p-p = 31.2 Hz) and cis-[Pd(PPh 3 ) 2 (N-morpholyn-N 0 -benzoylthioureato-k 2 O,S)]PF 6 ( 2 J p-p = 30.8 Hz). 80 The appearance of doublets for triphenylphosphine moieties indicates that the phosphorus atoms are non-equivalent due to geminal couplings of the P atoms with S and N atoms of the ligands. In the FT-IR spectra of complex 1 (Fig.…”

Crystal structure, Hirshfeld surface analysis, and DFT studies of N-(2-chlorophenylcarbamothioyl)cyclohexanecarboxamide

“…Among these, the Nbenzoyl thiourea derivatives are versatile ligands that coordinate to form stable compounds. These derivatives possess very strong donor groups (Carbonyl and thioamide) that allow the preparation of different transition metal complexes, either monoanionic bidentate form by deprotonation that forms neutral homoleptic or heteroleptic complexes with S,O coordination or in neutral form only through the S atom [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Several benzoyl thiourea derivatives and their metal complexes are also associated with various types of biological activities such as insecticidal, herbicidal, antibacterial, antifungal, anti-tubercular, antithyroid, anthelmintic, rodenticidal, and plant growth regulator properties [22][23][24][25].…”

Recent trends in chemistry, structure, and various applications of 1-acyl-3-substituted thioureas: a detailed review

“…Plutín et al 48 synthesized seven novel thiourea complexes of Pd( ii ) and then characterized them by elemental analysis and spectroscopic methods. The ligands a–g were combined with Pd( ii ) by reacting them with 57 in methanol to afford the complexes 58, 59(a–g) Scheme 16 .…”