Antitumor Activity of Leaves from <i>Hyptis mutabilis</i> (A. Rich.) Briq. (Lamiaceae) in Mice Bearing Tumor

Ximenes, Rafael Matos; Melo, Antônio Mario; Magalhães, Lucimeri Paulino Machado; Souza, Ivone Antônia de; Albuquerque, Julianna Ferreira Cavalcanti de

doi:10.7167/2013/169357

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…In both cases, larval settlement is induced, but further development of the larvae is stopped to the extent that tissues may undergo necrosis. It should be noted that the cytostatic activity of the extract from the White Sea H. panicea is comparable, for instance, to extracts from the leaves of the tropical plant of the genus Hyptis, which are widely used in traditional medicine and are currently under active study (Ximenes et al, 2013;Cui et al, 2017). Thus, the results of this study indicate that the water-soluble fraction of the extract from the White Sea sponge H. panicea has at least a cytostatic effect on live tissues, which may be of interest for development of new anti-cancer drugs.…”

Section: Discussionmentioning

confidence: 99%

Cytostatic activity in the hydrophilic fraction of the crude extract from the White Sea sponge Halichondria panicea

Khalaman

Chalisova

Краснов

et al. 2019

BioComm

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Halichondria panicea, commonly known as the breadcrumb sponge, is an ecologically aggressive and widespread species in the coastal waters of North Atlantic and North Pacific. Cytostatic activity of the water-soluble extract fraction from the White Sea sponge Halichondria panicea was tested using organotypic cultures of rat liver fragments. The study shows a pronounced negative dosedependent effect of the extract on the development of tissue explants of the test animals. Our results confirm toxicity of the White Sea Halichondria panicea, which was revealed earlier toward marine epibenthic organisms. The chemical nature of a substance or substances responsible for toxic effect is discussed.

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Section: Discussionmentioning

confidence: 99%

Cytostatic activity in the hydrophilic fraction of the crude extract from the White Sea sponge Halichondria panicea

Khalaman

Chalisova

Краснов

et al. 2019

BioComm

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Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Rolim

Meireles

Batista

et al. 2017

BMC Complement Altern Med

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BackgroundThe essential oil from Mesosphaerum sidifolium (L’Hérit.) Harley & J.F.B.Pastore (syn. Hyptis umbrosa), Lamiaceae (EOM), and its major component, have been tested for toxicity and antitumor activity.MethodsEOM was obtained from aerial parts of M. sidifolium subjected to hydro distillation, and gas chromatography-mass spectrometry was used to characterize the EOM chemical composition. The toxicity was evaluated using haemolysis assay, and acute toxicity and micronucleus tests. Ehrlich ascites carcinoma model was used to evaluate the in vivo antitumor activity and toxicity of EOM (50, 100 and 150 mg/kg), and fenchone (30 and 60 mg/kg) after 9 d of treatment.ResultsThe EOM major components were fenchone (24.8%), cubebol (6.9%), limonene (5.4%), spathulenol (4.5%), β-caryophyllene (4.6%) and α-cadinol (4.7%). The HC50 (concentration producing 50% haemolysis) was 494.9 μg/mL for EOM and higher than 3000 μg/mL for fenchone. The LD50 for EOM was approximately 500 mg/kg in mice. The essential oil induced increase of micronucleated erythrocytes only at 300 mg/kg, suggesting moderate genotoxicity. EOM (100 or 150 mg/kg) and fenchone (60 mg/kg) reduced all analyzed parameters (tumor volume and mass, and total viable cancer cells). Survival also increased for the treated animals with EOM and fenchone. For EOM 150 mg/kg and 5-FU treatment, most cells were arrested in the G0/G1 phase, whereas for fenchone, cells arrested in the S phase, which represents a blockage in cell cycle progression. Regarding the toxicological evaluation, EOM induced weight loss, but did not induce hematological, biochemical or histological (liver and kidneys) toxicity. Fenchone induced decrease of AST and ALT, suggesting liver damage.ConclusionsThe data showed EOM caused in vivo cell growth inhibition on Ehrlich ascites carcinoma model by inducing cell cycle arrest, without major changes in the toxicity parameters evaluated. In addition, this activity was associated with the presence of fenchone, its major component.

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The Essential Oil of Hyptis mutabilis in Ichthyophthirius multifiliis Infection and its Effect on Hematological, Biochemical, and Immunological Parameters in Silver Catfish, Rhamdia quelen

Cunha

Sutili

Oliveira

et al. 2017

Journal of Parasitology

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This study evaluated the activity of leaf essential oil (EO) from Hyptis mutabilis as well as its major constituent, (-)-globulol, in infections by the parasite Ichthyophthirius multifiliis (ich). Effects on hematological, biochemical, and immunological parameters of silver catfish, Rhamdia quelen, exposed to the same samples also were evaluated. In the first experiment, naturally infected fish were treated with EO (0, 10, and 20 mg · L) and ethanol, using several methods of exposure. Fish mortality and the number of trophonts per fish were assessed after 48 and 96 hr. Hour-long daily baths resulted in optimal survival, so this methodology was used for the second experiment, in which infected animals were exposed to (-)-globulol at 2.5 and 5 mg · L. The most effective concentrations in Experiments 1 and 2 were chosen for Experiment 3, in which healthy animals were subjected to hour-long daily baths with EO (20 mg · L) or (-)-globulol (2.5 mg · L). Additionally, an in vitro experiment was performed with EO and globulol at the same concentrations of the in vivo test. EO and (-)-globulol increased the survival of fish infected with ich and altered certain hematological and biochemical parameters. After 4 days, levels of hematocrit, erythrocytes, and leukocytes increased significantly in healthy animals exposed to EO. Exposure to (-)-globulol increased leukocyte number alone. No significant differences in nonspecific immunological parameters were detected when treated groups were compared to controls, but the leukocytosis observed in EO- and globulol-treated healthy animals indicates that EO and (-)-globulol increased innate immunity in these fish. An in vitro antiparasitic effect was observed in both samples.

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Antitumor Activity of Leaves from Hyptis mutabilis (A. Rich.) Briq. (Lamiaceae) in Mice Bearing Tumor

Cited by 3 publications

References 17 publications

Cytostatic activity in the hydrophilic fraction of the crude extract from the White Sea sponge Halichondria panicea

Cytostatic activity in the hydrophilic fraction of the crude extract from the White Sea sponge Halichondria panicea

Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

The Essential Oil of Hyptis mutabilis in Ichthyophthirius multifiliis Infection and its Effect on Hematological, Biochemical, and Immunological Parameters in Silver Catfish, Rhamdia quelen

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