Antitumor Activity of Jujuboside B and the Underlying Mechanism via Induction of Apoptosis and Autophagy

Xu, Mengdan; Lee, So Young; Kang, Sam Sik; Kim, Yeong Shik

doi:10.1021/np401022g

Cited by 59 publications

(39 citation statements)

References 38 publications

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“…spinosa , induced apoptosis and autophagy in human AGS and HCT-116 gastric adenocarcinoma cells in vitro and effectively suppressed tumor growth in a nude mouse xenograft model bearing HCT-116 cells in vivo [248]. Moreover, jujuboside B activated p38/c-Jun N-terminal kinase (JNK), and induced autophagy indicated by the formation of cytoplasmic vacuoles and LC3B-I/II conversion [248]. The autophagy inhibitor bafilomycin A1 decreased jujuboside B-induced cell viability, as indicated [248].…”

Section: Anticancer Natural Compounds and Autophagymentioning

confidence: 99%

“…Moreover, jujuboside B activated p38/c-Jun N-terminal kinase (JNK), and induced autophagy indicated by the formation of cytoplasmic vacuoles and LC3B-I/II conversion [248]. The autophagy inhibitor bafilomycin A1 decreased jujuboside B-induced cell viability, as indicated [248]. Feroniellin A (FERO), a novel furanocoumarin, was shown to induce autophagy, associated with LC3B-I to LC3B-II conversion, induction of GFP-LC3B puncta, enhanced expression of BECN1 and ATG5, and inactivation of mTOR in etoposide-resistant human lung carcinoma A549RT-eto cells [249].…”

Section: Anticancer Natural Compounds and Autophagymentioning

confidence: 99%

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Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells

Guamán-Ortiz

Orellana²,

Ratovitski³

2017

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Cell death is an innate capability of cells to be removed from microenvironment, if and when they are damaged by multiple stresses. Cell death is often regulated by multiple molecular pathways and mechanism, including apoptosis, autophagy, and necroptosis. The molecular network underlying these processes is often intertwined and one pathway can dynamically shift to another one acquiring certain protein components, in particular upon treatment with various drugs. The strategy to treat human cancer ultimately relies on the ability of anticancer therapeutics to induce tumor-specific cell death, while leaving normal adjacent cells undamaged. However, tumor cells often develop the resistance to the drug-induced cell death, thus representing a great challenge for the anticancer approaches. Numerous compounds originated from the natural sources and biopharmaceutical industries are applied today in clinics showing advantageous results. However, some exhibit serious toxic side effects. Thus, novel effective therapeutic approaches in treating cancers are continued to be developed. Natural compounds with anticancer activity have gained a great interest among researchers and clinicians alike since they have shown more favorable safety and efficacy then the synthetic marketed drugs. Numerous studies in vitro and in vivo have found that several natural compounds display promising anticancer potentials. This review underlines certain information regarding the role of natural compounds from plants, microorganisms and sea life forms, which are able to induce non-apoptotic cell death in tumor cells, namely autophagy and necroptosis.

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Section: Anticancer Natural Compounds and Autophagymentioning

confidence: 99%

Section: Anticancer Natural Compounds and Autophagymentioning

confidence: 99%

Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells

Guamán-Ortiz

Orellana²,

Ratovitski³

2017

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“…Apparently, the composition and amount of triterpenic acids in jujube fruits can be affected by species, growing season, as well as geographical and environmental conditions (Guo et al 2010b). In addition, both jujubosides A and B are also present in jujube fruits, which have been demonstrated to possess biological functions such as anti-proliferation of cancer cells (Xu et al 2014).…”

Section: Triterpenic Acidsmentioning

confidence: 99%

Functional components in Zizyphus with emphasis on polysaccharides

Kao

Chen

2014

Polysaccharides

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Zizyphus jujuba (Chinese jujube), mainly distributed in the subtropical regions of Asia, has been cultivated for over 4,000 years and used as food, food additive, flavor, as well as traditional Chinese herb, as it possesses analeptic, palliative, and antibechic functions. The fruit of jujube is quite popular due to high nutritional value and presence of many functional components, in which polysaccharide is the most important one. Polysaccharides, being essential constituents of all living organisms, are naturally occurring polymers of aldoses and ketoses linked together through glycosidic linkages. In recent years, polysaccharides of plant origin have emerged as a vital class of bioactive nature products; however, there is a lack of information regarding analysis and biological activity of jujube polysaccharides. Moreover, the composition of polysaccharides in jujube may vary with different species, growth environment, cultivar variety, and extraction and separation methods, which in turn may affect the overall biological activity. The objective of this manuscript is to review the current status associated with jujube polysaccharide, including nutritional and functional components; methods of extraction, purification, separation, identification, and quantitation; as well as biological activity.

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“…Many studies demonstrated that pretreatment with SB202190 reversed the apoptotic events induced by several saponins [21,34]. Likewise, pretreatment with SB202190 inhibited the activation of caspases and cleavage of PARP1 induced by compound 1, suggesting that the activation of p38 may be responsible for the compound 1-induced apoptosis.…”

Section: Discussionmentioning

confidence: 99%

A triterpenoid saponin from Adenophora triphylla var. japonica suppresses the growth of human gastric cancer cells via regulation of apoptosis and autophagy

2014

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In the present study, we investigated the effects of 3-O-β-D-galactopyranosyl-(1 → 2)-[β-D-xylopyranosyl-(1 → 3)]-β-D-glucuronopyranosyl-28-O-[α-L-arabinopyranosyl-(1 → 4)-α-L-arabinopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-β-D-fucopyranosyl] quillaic acid, named compound 1, on the induction of apoptosis and autophagy in human gastric cancer AGS cells. Compound 1, a triterpenoid saponin isolated from the root of Adenophora triphylla var. japonica, effectively inhibited the growth of AGS cells by inducing apoptosis, as well as autophagy. Apoptosis by compound 1 treatment was associated with activation of caspases, release of cytochrome c, and increased ratio of Bax/Bcl-2. Autophagy by compound 1 treatment was indicated by LC3-II protein expression. We also found an increase in phosphorylation of p38 and JNK and a decrease in phosphorylation of ERK and Akt after compound 1 treatment. Furthermore, pretreatment with p38 inhibitor SB202190 completely inhibited compound 1-induced activation of caspases and cleavage of PARP1, whereas pretreatment with SB202190 synergistically increased the protein expression of LC3-II. These results suggest that compound 1 distinctly induces apoptotic and autophagic cell death and the increased autophagy by SB202190 protects compound 1-induced AGS cell death. Our findings provide an important clue for exploring the potential anticancer role of compound 1.

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Antitumor Activity of Jujuboside B and the Underlying Mechanism via Induction of Apoptosis and Autophagy

Cited by 59 publications

References 38 publications

Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells

Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells

Functional components in Zizyphus with emphasis on polysaccharides

A triterpenoid saponin from Adenophora triphylla var. japonica suppresses the growth of human gastric cancer cells via regulation of apoptosis and autophagy

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