“…ENO1 encodes α-enolase, which is one of the three enolase isozymes found in mammals ( Zhang et al, 2020 ). ENO1 is overexpressed in a variety of GI tumors, including colon, pancreatic, and gastric cancers ( Hang et al, 2018 ), and promotes tumor development ( Cheng et al, 2019 ; Xu et al, 2019 ). In addition, ENO1 is highly expressed in liver cancer, promotes glucose uptake and lactate production by tumor cells, and is involved in tumor cell division, proliferation, apoptosis, metastasis, immunomodulation, and chemoresistance ( Qiao et al, 2018 ; Jiang et al, 2020 ).…”