2013
DOI: 10.1038/cddis.2013.166
|View full text |Cite
|
Sign up to set email alerts
|

Antitumor activity of IL-32β through the activation of lymphocytes, and the inactivation of NF-κB and STAT3 signals

Abstract: Cytokine and activation of lymphocytes are critical for tumor growth. We investigated whether interleukin (IL)-32β overexpression changes other cytokine levels and activates cytotoxic lymphocyte, and thus modify tumor growth. Herein, IL-32β inhibited B16 melanoma growth in IL-32β-overexpressing transgenic mice (IL-32β mice), and downregulated the expressions of anti-apoptotic proteins (bcl-2, IAP, and XIAP) and cell growth regulatory proteins (Ki-67 antigen (Ki-67) and proliferating cell nuclear antigen (PCNA)… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

3
61
1

Year Published

2014
2014
2019
2019

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 54 publications
(67 citation statements)
references
References 54 publications
(62 reference statements)
3
61
1
Order By: Relevance
“…In previous studies, we also demonstrated an inhibitory role of the IL-32 isoforms (α, β, γ) in inflammatory diseases 19, 21, cancer 61, 62, 64, 65, and liver damage 18, 23. Interestingly, a previous study suggested a paradoxical dual function of IL-32γ in colitis 66.…”
Section: Discussionmentioning
confidence: 57%
“…In previous studies, we also demonstrated an inhibitory role of the IL-32 isoforms (α, β, γ) in inflammatory diseases 19, 21, cancer 61, 62, 64, 65, and liver damage 18, 23. Interestingly, a previous study suggested a paradoxical dual function of IL-32γ in colitis 66.…”
Section: Discussionmentioning
confidence: 57%
“…Yun et al (2013) demonstrated that IL-32 inhibits tumor growth through the increase in the number of cytotoxic lymphocytes. Yun et al (2013) demonstrated that IL-32 inhibits tumor growth through the increase in the number of cytotoxic lymphocytes.…”
Section: Il-32 and Cancermentioning
confidence: 99%
“…Finally, HFD promoted pro‐inflammatory cytokines such as IL‐1β, IL‐6, and TNF‐α in mouse liver, but did not promote other cytokines such as IL‐4, IL‐10, IL‐11, IL‐13, IL‐15, and IFN‐γ . We previously reported that IL‐32β showed antitumor activity in IL‐32β mice and modulated the levels of cytokines such as IL‐6, TNF‐α, IL‐1β, and IL‐10 . Kang et al reported that IL‐32β promotes the production of IL‐10, which is an anti‐inflammatory cytokine in human myeloid cells .…”
Section: Discussionmentioning
confidence: 80%