Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis

Shen, Haoming; Li, Lan‐Zhen; Xue, Ke‐Cheng; Hu, Dandan; Gao, Yujun

doi:10.3892/mmr.2017.6338

Cited by 25 publications

(19 citation statements)

References 27 publications

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“…Also, further studies are needed to clarify the mechanism of action responsible for the protection fucoidan affords. Fucoidan can inhibit cell growth, induce apoptosis and suppress angiogenesis of thyroid cancer cells [28]. This finding suggests that fucoidan administration could selectively protect SGs against RI-induced damage while not having a negative effect on the treatment of thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

Fucoidan attenuates radioiodine-induced salivary gland dysfunction in mice

Kim

et al. 2019

BMC Oral Health

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Background Radioiodine (RI) treatments can destroy the cellular components of salivary glands (SG) and disrupt their function. This study investigated whether fucoidan could attenuate radioiodine-induced SG dysfunction in a mouse model. Methods Female C57BL/6 mice ( n = 36) were classified into three groups; i) a normal (control) group, ii) an RI-treated group (0.2 mCi/20 g mouse, administered orally), and iii) a fucoidan and RI-treated group. Mice in each group were classified into three subgroups and sacrificed at 2, 4, and 12 weeks after RI treatment. The measurements of salivary flow rates and lag times and histomorphologic examinations were performed, and apoptotic assays were conducted. Changes in salivary 99m Technetium (Tc)-pertechnetate parameters using single-photon emission computed tomography were followed. Results Salivary flow rates and lag times in the fucoidan group were improved compared to the RI-treated group. Histologic examinations of SGs in the fucoidan group showed mucin-rich parenchymal areas and reduced periductal fibrosis as compared to the RI-treated group. Moreover, compared with the RI-treated group, fucoidan-treated groups showed evidence of cytoprotection, with a greater number of salivary epithelial cells and myoepithelial cells being observed. Fewer apoptotic cells were observed in the fucoidan group as compared to the RI group. The extent of 99m Tc pertechnetate excretion in the fucoidan group was similar to that of the control group. Conclusion Our results demonstrate that fucoidan administration before RI treatment could attenuate RI-induced SG damage and provides a possible candidate for preventing SG damage induced by RI.

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Section: Discussionmentioning

confidence: 99%

Fucoidan attenuates radioiodine-induced salivary gland dysfunction in mice

Kim

et al. 2019

BMC Oral Health

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“…Induction of apoptosis is one important mechanism by which an antitumor agent acts [ 38 ]. Some previous research has demonstrated that polysaccharides induce the apoptosis of cancer cells by promoting the expression levels of cleaved poly ADP-ribose polymerase (PARP) and caspase-3 [ 39 , 40 , 41 ]. Therefore, it is worthwhile to have a further study of the mechanism for the effects of CF1 on DU145 prostate cancer cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Isolation, Characterization and Antitumor Effect on DU145 Cells of a Main Polysaccharide in Pollen of Chinese Wolfberry

Chen

Ran

et al. 2018

Molecules

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Modern studies have shown that pollen has a certain role in the treatment of prostate-related diseases. In the present study, pollen polysaccharides from Chinese wolfberry (WPPs) were extracted by hot-water extraction and ethanol precipitation, further purified by chromatography on a DEAE-cellulose column and Sephadex G-100 column. Homogeneous polysaccharide CF1 of WPPS was obtained, the molecular weight of which was estimated to be 1540.10 ± 48.78 kDa by HPGPC-ELSD. HPLC with PMP derivatization analysis indicated that the monosaccharide compositions of CF1 were mannose, glucuronic acid, galacturonic acid, xylose, galactose, arabinose, and trehalose, in a molar ratio of 0.68:0.59:0.27:0.24:0.22:0.67:0.08. The antitumor effects of CF1 upon MTT, Tunel assay and flow cytometry assay were investigated in vitro. The results showed that CF1 exhibited a dose-dependent antiproliferative effect, with an IC50 value of 374.11 μg/mL against DU145 prostate cancer cells. Tunel assay and flow cytometry assay showed that the antitumor activity of CF1 was related to apoptosis in vitro. The present study suggested that the CF1 of WPPs might be a potential source of antitumor functional food or agent.

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“…Regarding prostate cancer, fucoidan was reported to inhibit human cancer cells proliferation by reducing specific endothelial markers including VEGF (Rui, Pan, Shao, & Xu, 2017). Likewise, fucoidan from F. vesiculosus inhibited the growth of human thyroid cancer cells and suppressed angiogenesis (Shen, Li, Xue, Hu, & Gao, 2017). There is only one study that relates breast cancer with the anti-angiogenic potential of fucoidan, at where micro-vessels reduction was observed in a mouse breast cancer cell model when fucoidan was injected (Xue et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo

Oliveira

Granja

Neves

et al. 2019

Carbohydrate Polymers

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Fucoidan is a marine-origin sulfated polysaccharide that can show anticancer activity, to which both pro-and anti-angiogenic responses have been reported. Due to this unpredictability, the angiogenic potential of an effective anticancer crude fucoidan (CF), at a concentration of 0.5 mg mL −1 , was evaluated. Tube formation assays demonstrated that CF, either administered while endothelial cells seeding or after their adhesion, migration and organization, inhibited or disrupted the formation of tubular-like structures, respectively. Although CF did not significantly reduced vascular endothelial growth factor (VEGF) secretion, it significantly reduced the expression of platelet-derived growth factor (PDGF), compromising the blood vessels maturation. Two chicken embryo chorioallantoic membrane (CAM) assays were performed: one without tumor (CAM I) and the other with an onplanted tumor mass (CAM II); the CF injection reduced the number of blood of vessels and significantly decreased the tumor size, respectively. In vitro and in vivo results support the effectiveness of fucoidan as a natural antitumor therapeutic agent.

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Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis

Cited by 25 publications

References 27 publications

Fucoidan attenuates radioiodine-induced salivary gland dysfunction in mice

Fucoidan attenuates radioiodine-induced salivary gland dysfunction in mice

Isolation, Characterization and Antitumor Effect on DU145 Cells of a Main Polysaccharide in Pollen of Chinese Wolfberry

Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo

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