Antitumor activity of ethanol and aqueous extracts of &amp;lt;i&amp;gt;Drosera burmannii&amp;lt;/i&amp;gt; vahl. in EAC bearing mice.

Raju, Asirvatham; Christina, A. J. M.; Murali, Anita

doi:10.5455/spatula.20120501080940

Cited by 11 publications

(8 citation statements)

References 12 publications

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“…Drosera indica L. possesses an effective antioxidant and anticancer activities. This is due to the presence of phytochemicals like naphthoquinones and quercetinetc 20 .Solvent extraction studies show (Table 1) that the ethanolic extract of Drosera indica L. has the highest yield (4.2 % ), whereas ethylacetate extract has the lowest yield percentage (0.08 %). Phytochemical Screening of the plant reveals the presence of the numerous chemicals including flavanoids, cardiac glycosides, saponins, tannins and polyphenols.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Preliminary Phytochemical Screening and Free Radical Scavenging Ability of Drosera indica L.

Asha

Hemmalakshmi

Suriyamoorthy

et al. 2017

IJPCR

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Aim: The present study is carried out to explore the preliminary phytochemical screening and free radical scavenging activity of the whole plant Drosera indica L. Methods: a) Phytochemical screening – The qualitative analysis of secondary metabolites is carried out by the standard qualitative methods. b) In vitro free radical scavenging activity of the ethanolic and aqueous extract of the whole plant Drosera indica L is used for the analysis .Various concentrations (100 – 500mcg/ml) of the ethanol and aqueous extracts of Drosera indica L. are used in the various antioxidant assay methods such as reducing power, ferric reducing antioxidant power assay (FRAP), nitric oxide (NO) radical,2,2’ azinobis-3 ethylbenzothiozoline-6 sulfonic acid (ABTS+) radical, hydroxyl radical (OH.), 1,1-diphenyl-2-picryl hydroxyl (DPPH) radical , super oxide radical and hydrogen peroxide (H2O2) is carried out with the standard protocols. In all the assays ascorbic acid is used as the standard antioxidant. Results: Phytochemical screening of the plants reveal the presence of numerous chemicals including flavanoids, tannins, polyphenols, cardiac glycosides and saponins. The ethanolic extract of Drosera indica L. shows better ability to scavenge ,1,1-diphenyl-2-picryl hydroxyl( DPPH)radical, hydroxyl radical, hydrogen peroxide, nitric oxide radical and superoxide radical. FRAP and the reducing power abilities of the ethanolic extract is increased with the increase in concentration of the plant extract. Conclusion: The ethanolic extract of Drosera indica L. shows better ability to scavenge the free radicals than the aqueous extract. From this study, a conclusion is drawn that Drosera indica L. can have more beneficial effects with respect to the presence of many active secondary metabolites which may likely to combat with the oxidative stress diseases like diabetes, cancer, cardio-vascular diseases and in general boost the immune system.

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Section: Resultsmentioning

confidence: 99%

In Vitro Preliminary Phytochemical Screening and Free Radical Scavenging Ability of Drosera indica L.

Asha

Hemmalakshmi

Suriyamoorthy

et al. 2017

IJPCR

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“…Medicinal plants have various phytoconstituents which are an excellent source of lead compounds to develop therapeutic drugs including anticancer agents. Therefore, many studies have been conducted on herbs for various ethnobotany reasons (Newman & Cragg, 2009) The antitumor properties of the extracts from these plant species have already been reported (Raju et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant potential of Drosera peltata in Dalton Ascites Lymphoma (DAL) bearing mice

Asirvatham

Christina

2023

ijpbp

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Cancer is one of the prominent causes of death reported by World Health Organization (WHO). The purpose of this study was to measure the antioxidant status of animals treated with 250 and 500 mg/kg doses of ethanol and aqueous extract of Drosera peltata on Dalton Ascites Lymphoma (DAL) inoculated mice. A total of 70 mice were divided into 7 groups, each group with ten mice. The first group (negative control) received normal food and water for 14 days and was kept under normal conditions. The second group also received normal food and water for 14 days, which was used as a cancer (positive) control. The third group received 5-fluorouracil (20 mg/kg, i.p.) once a day for 14 days. The fourth and fifth group animals received 250 and 500 mg/kg of ethanol extracts of D. peltata (EEDP) whereas the sixth and seventh groups of mice received 250 and 500 mg/kg of aqueous extracts of D. peltata (AEDP), orally for 14 days. All the groups were inoculated with DAL (2 × 10 6 cells/mouse, i.p.) except group I, 24 hours before the commencement of the drug treatment. After the completion of treatment, blood was drawn retro-orbitally and the animals were sacrificed to isolate the liver, lungs, kidneys, and brain for observing tissue antioxidant status. The parameters analyzed were total protein (TP), catalase (CAT), malondialdehyde (MDA), superoxide dismutase (SOD), peroxidase (P), and glutathione (GSH) from the tissues apart, and the protein carbonyl content (PCC) also measured from the blood sample. Treatment with EEDP and AEDP significantly lowered the MDA levels from 23 to 10 mmol/ml in the blood, whereas from 28 to 4 nm/g in tissue isolates of the liver, lungs, kidneys, and brain. It also raised the TP, GSH, SOD, CAT, and P levels in the blood and in the tissue samples of the cancer cell line inoculated animals, where their levels were close to those observed in control (negative) group animals. The results proposed that both extracts of D. peltata ameliorated various tissue antioxidant levels in mice with DAL cancer lines comparable to the negative control.

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“…Medicinal plants have various phytoconstituents which are an excellent source of lead to develop therapeutic drugs including anticancer agents. Therefore, many studies have been conducted on herbs for various ethnobotany reasons (Cragg and Nweman, 2009) The antitumor properties of these plant species extract have already been reported (Raju et al, 2012). This study was conducted to estimate the antioxidant status in blood and various organs and the effectiveness of EEDP and AEDP on the restoration of these enzymes in cancer-bearing animals.…”

Section: Discussionmentioning

confidence: 99%

Sustainment of Antioxidant Enzymes by Drosera peltata in Ehrlich's Ascites Carcinoma (EAC) Bearing Mice

Raju¹,

Ajm²

2022

Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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The purpose of this study was to measure the antioxidant status of animals treated with 250 and 500 mg / kg doses of ethanol and aqueous extract of Drosera peltata on Erich ascites carcinoma (EAC) inoculated mice. A total of 70 mice were divided into 7 groups, each group with ten mice. The first group received normal food and water for 14 days and was under normal control. The second group also received normal food and water for 14 days, which was cancer control. Third group received 5- flurouracil (20 mg/kg, i.p) for 14 days. Fourth and fifth group animals received 250 and 500 mg / kg of ethanol extracts of D. peltata (EEDP) whereas the sixth and seventh groups of mice received 250 and 500 mg / kg of aqueous extracts of D. peltata (AEDP), orally for 14 days. All the groups were inoculated with EAC (2×106 cells/mouse, i.p.) except Group I, 24 hours before the commencement of the drug treatment. After the completion of treatment, blood was drawn retro-orbitally and sacrificed to isolate the liver, lungs, kidneys, and brain for observing tissue antioxidant status. The parameters analyzed were total protein (TP), catalase (CAT), malondialdehyde (MDA), superoxide dismutase (SOD), peroxidase (P), and glutathione (GSH) from the tissues apart and the protein carbonyl content (PCC) also measured from the blood sample. Treatment with EEDP and AEDP significantly lowers the MDA levels from 23 to 10 mmol/ml in the blood whereas 28 to 4 nm/g tissue isolates the liver, lungs, kidneys, and brain. It also raised the TP, GSH, SOD, CAT, and P levels in the blood and the tissues sample of the cancer cell line inoculated animals, and their levels are maintained similarly to normal group animals. The results proposed that both the extracts of D. peltata retained the various tissue antioxidant statuses in mice with EAC cancer lines.

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Antitumor activity of ethanol and aqueous extracts of <i>Drosera burmannii</i> vahl. in EAC bearing mice.

Cited by 11 publications

References 12 publications

In Vitro Preliminary Phytochemical Screening and Free Radical Scavenging Ability of Drosera indica L.

In Vitro Preliminary Phytochemical Screening and Free Radical Scavenging Ability of Drosera indica L.

Antioxidant potential of Drosera peltata in Dalton Ascites Lymphoma (DAL) bearing mice

Sustainment of Antioxidant Enzymes by Drosera peltata in Ehrlich's Ascites Carcinoma (EAC) Bearing Mice

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