Antitumor Activity of Corni Fructus Ethanol Extract in Sarcoma-180 Cancer Cells

권승혁,; 권순재,; 김재용,; 강갑석,; 심기환,; 이미경,; 서권일,

doi:10.3746/jkfn.2010.39.7.960

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Previous studies reported cytotoxic activity of some Cornus species extracts ( C. officinalis fruits—aqueous, ethanolic extracts, C. amomum ). In vitro antiproliferative effects of these extracts were described for several cell line types (HT29, HCT116—colon cancer, MCF-7, MDA-MB-231—breast cancer) [6,7,8]. Antiproliferative activity was described for some Cornaceae-isolated pure compounds—morroniside ( C. officinalis —fruits), betulinic acid derivatives and other non-polar compounds ( C. florida —bark), and anthocyanins, such as delphinidin 3- O -glucoside and delphinidin 3- O -rutinoside ( C. alternifolia, C. controversa —fruits) [5,9,10].…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative Activities of Water Infusions from Leaves of Five Cornus L. Species

et al. 2015

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Abstract:Cornaceae plants are known for their edible berries, and their leaves are used as tea. In the present study aqueous leaf extracts from Cornus mas (CM), C. alba (CA), C. flaviramea (CF), C. kousa (CK), and C. officinalis (CO) were tested for their antiproliferative activity in human breast cancer cells (MCF-7). Dose-(50-750 µg/mL) and time (24, 48, 72 h)-dependent antiproliferative effects were measured by WST-1, and correlated with the content of flavonoids (FL), total hydroxycinnamic derivatives (THD), total polyphenols (TP) and tannins (T). Extracts induced time dependent decreases in cell survival; CA, CO and CM were the most effective (11.2%, 10.3% and 11.1%, after 72 h). The ED 50 (effective dose) values were similar for all extracts and times tested. The THD and TP were identical in all samples, while a two-fold higher T content was present in CK and CO, and of FL in CF. The maximal effects (% of surviving cells) negatively correlated with the T and TP levels, and positively with FL and THD. The results demonstrate the significant antiproliferative effects of the tested water extracts in MCF-7 cells, in which CA, CO and CM are the most effective; and the effectiveness is related to the T and TP contents.

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Section: Introductionmentioning

confidence: 99%

Antiproliferative Activities of Water Infusions from Leaves of Five Cornus L. Species

et al. 2015

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Change of Physiological Activities of Chungkukjang according to the Addition Stage of Cornus officinalis, Heat Treatment and Salt Concentration

Oh¹,

Min²

2017

EASDL

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Anti-Fatigue Effect of Cornus officinalis Sieb. et Zucc. Extract in Forced Swimming Test

Lee

Shin

Noh

et al. 2021

JKFN

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This study examined the effects of Corni Fructus administration on the exercise performance and fatigue accumulation in the forced swimming test (FST). The ICR mice were divided randomly into four groups: water-treated FST (control), 500 mg/kg of red ginseng-treated FST (RG), 500 mg/kg of water extract of Corni Fructus-treated FST (CFW), and 500 mg/kg of 30% EtOH extract of Corni Fructus-treated FST (CFE). After FST, an autopsy was performed, and the soleus muscle and serum were collected. The experimental result show that the running time increased in the CFW. In addition, the soleus muscle showed that glycogen was increased by CFW and CFE. Furthermore, CFW significantly regulated GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyruvic transaminase), BUN (blood urea nitrogen), ammonia, LDH (lactate dehydrogenase), D-lactate, TG (triglyceride), and FFA (free fatty acid) in serum. On the other hand, CFE regulated the above factors but not significantly. Overall, CFW and CFE in FST are considered effective in preventing fatigue by controlling the liver enzyme, kidney enzyme, and fatigue-related factors, and the CFW is considered to be more effective than CFE.

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Antitumor Activity of Corni Fructus Ethanol Extract in Sarcoma-180 Cancer Cells

Cited by 4 publications

References 10 publications

Antiproliferative Activities of Water Infusions from Leaves of Five Cornus L. Species

Antiproliferative Activities of Water Infusions from Leaves of Five Cornus L. Species

Change of Physiological Activities of Chungkukjang according to the Addition Stage of Cornus officinalis, Heat Treatment and Salt Concentration

Anti-Fatigue Effect of Cornus officinalis Sieb. et Zucc. Extract in Forced Swimming Test

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