Antitumor activity of afatinib in EGFR T790M-negative human oral cancer therapeutically targets mTOR/Mcl-1 signaling axis
Jung-Min Han,
Kyu-Young Oh,
Su-Jung Choi
et al.
Abstract:Purpose
This study investigates the role and effectiveness of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in oral cancer, focusing on the clinical relevance of EGFR and myeloid cell leukemia-1 (Mcl-1) in head and neck cancers (HNCs). It aims to explore the molecular mechanism of afatinib, a TKI, in treating human oral cancer.
Methods
We conducted an in silico analysis using databases like The Cancer Genome Atlas, Gene Expres… Show more
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