Antitumor activity and toxicity of peroxo heteroligand vanadates(V) in relation to biochemistry of vanadium

Djordjević, C.; Wampler, Galen L.

doi:10.1016/0162-0134(85)83007-5

Cited by 135 publications

(64 citation statements)

References 16 publications

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“…It is suggested that they might be used in chemotherapy due to their antiproliferative activity, cytostatic/cytotoxic activity (in apoptotic or necrotic way) and antimetastatic activity [16,71,72]. Parallel to reports on anticancer properties of vanadium derivatives, studies on their action in initiation and promotion of the neoplastic transformation have been reported [73,74].…”

Section: Pro-and Anticancer Properties Of Vanadiummentioning

confidence: 85%

Biological activity of vanadium compounds

Goc

2006

Open Life Sciences

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Vanadium compounds are characterised by a broad spectrum of action in vivo and in vitro. Their insulin-mimetic activity is manifested in their ability to normalize changes observed in both clinical and experimental diabetes (i.e. hyperglycaemia, hyperlipidaemia, lowered cell sensitivity to insulin) through the regulation of carbohydrate and lipid metabolism and the removal of secondary symptoms of this disease (as e.g. retinopathy, cardiomyopathy, nephropathy). Nevertheless, vanadium is considered to be a toxic element in both cationic and anionic form, although the latter type has more serious side effects. This is accounted for by the faster absorption of anionic forms, although the chemical structure, geometry, and the manner of synthesis of its derivatives also contributes to this elevated toxicity. Besides their antidiabetic properties, vanadium derivatives have also been observed to influence processes related to mitogenic cell responses (apoptosis, proliferation, neoplastic transformation). However, both anti-and pro-neoplastic properties of vanadium are reported.

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Section: Pro-and Anticancer Properties Of Vanadiummentioning

confidence: 85%

Biological activity of vanadium compounds

Goc

2006

Open Life Sciences

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“…Some experiments performed in 80's of the XXth century have shown that vanadium compounds are characterized by properties which make the glucose level lower in diabetes [3,4]. Since then, one is seeking for vanadium compounds which have a lowering influence on the glucose level without side effects such as vomiting, diarrhea, and lowering of body mass, which are observed after high dose of vanadium administration [5,6]. Therefore, the aim of this study was to investigate the influence of vanadium (IV) and (V) compounds on K, Ca, Mn, Fe, Cu, and Zn concentrations in kidney, spleen, and pancreas.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Trace Element Concentration in Diabetic Rat's Tissues

et al. 2009

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Diabetes is one of the most frequent diseases in developing countries and thus there is a significant interest in diabetes related studies. It was found that vanadium compounds have glucose-lowering properties in diabetes and therefore it is very important to estimate the vanadium dose in diabetes treatment. On the other hand, the proper estimation of vanadium concentration is important due to side effects that occur in vanadium supplementation. In this study the influence of V(IV) and V(V) compounds with different ligands on the concentration of K, Ca, Mn, Fe, Cu, and Zn in selected rat's tissues was investigated by means of proton induced X-ray emission technique. As a result of the measurements it was found that the concentration of vanadium depends on the organ. The highest value was determined in spleen while the lowest in pancreas. It was also found that the concentration of other elements depends on the presence of vanadium and its concentration. The most meaningful influence of vanadium presence was on iron concentration in spleen, on copper and zinc in kidney, and on manganese in pancreas.

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“…Although Kingsnorth et al (1986) observed that vanadate supplementation in diet or drinking water had little or no effect on 1,2-dimethylhydrazine-induced colon cancer in mice. Djordjevic and Wampler (1985) reported a significant antitumour activity of vanadium complexes against L1210 murine leukaemia. Vanadium at > 10-6M inhibited in vitro tumour colony formation, as was evident from a human tumour cloning assay (Hanauske et al, 1987).…”

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confidence: 99%

Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital

Bishayee

Chatterjee²

1995

Br J Cancer

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Summanr The chemoprotective effect of vanadium, a dietary micronutnrent. against chemically induced hepatocarcinogenesis in rats was investigated. Initiation was performed by a single intraperitoneal injection of diethylnitrosamine (DENA; 200 mg kg-') followed by promotion with phenobarbital (0.05 %) in the diet.Supplementary vanadium (0.5 p.p.m.) in the drinking water was provided ad libitum throughout the experiment. before the initiation or during the promotion period. At the end of the study (20 weeks Sabbioni et al., 1991: French and Jones, 1993Bishayee and Chatterjee, 1994). Scanning of pertinent literature reveals that many naturally occurring products and trace elements present in various foods may prevent, halt or reverse the neoplastic process (Wattenberg, 1985;Greenwald et al., 1987). Vanadium, an endogenous constituent of all or most mammalian tissues, is believed to have a regulatory role in biological systems (Crans et al., 1989;Gullapalli et al., 1989). Studies carried out in the last decade suggest that this transition metal could be considered a representative of a new class of non-platinum group metal anti-tumour agents (Kopf-Maier, 1987). Although Kingsnorth et al. (1986) observed that vanadate supplementation in diet or drinking water had little or no effect on 1,2-dimethylhydrazine-induced colon cancer in mice. Djordjevic and Wampler (1985) reported a significant antitumour activity of vanadium complexes against L1210 murine leukaemia. Vanadium at > 10-6M inhibited in vitro tumour colony formation, as was evident from a human tumour cloning assay (Hanauske et al., 1987). Dietary vanadium was found to block the induction of murine mammary carcinogenesis by 1-methyl-l-nitrosourea (Thompson et al., 1984). Previously, we have documented a significant protective response of vanadium (Sardar et al.. 1993) Chatterjee, 1995). The observed chemoprotective action of vanadium was found to be mediated through inhibition of altered liver cell foci and hepatic nodule growth during the early stages of neoplastic transformation (Bishayee and Chatterjee. 1995). However, in this study vanadium supplementation was done during the entire course of our experiment and it was not possible to ascertain at which time point this trace element was most effective. In order to explore this area, we initiated a new series of experiments in which the anticarcinogenic potential of vanadium was critically examined before the initiation as well as during the early promotion phase of experimentally induced hepatocarcinogenesis. Our present study is an attempt to gain more quantitative information regarding the morphometric analysis of y-glutamyltranspeptidase (GGT)-positive hepatocyte foci and nodules together with remodelling and altered enzyme activities of GGT in the presence or absence of vanadium during DENA-induced hepatocarcinogenesis in rats. The rationale behind the selection of these parameters lies in the fact that hepatocyte foci demonstrating altered enzyme phenotypes including GGT expression are generally acce...

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Antitumor activity and toxicity of peroxo heteroligand vanadates(V) in relation to biochemistry of vanadium

Cited by 135 publications

References 16 publications

Biological activity of vanadium compounds

Biological activity of vanadium compounds

Investigation of Trace Element Concentration in Diabetic Rat's Tissues

Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital

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