Antitumor activities of D-glucosamine and its derivatives

Zhang, Li; Liu, Wanshun; Han, Baoqin; Peng, Yanfei; Wang, Dongfeng

doi:10.1631/jzus.2006.b0608

Cited by 26 publications

(16 citation statements)

References 25 publications

(23 reference statements)

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“…The same group reported Janus Mg microspheres half coated with the biocompatible polymer poly(caprolactone) and demonstrated self-propulsion in aqueous solutions containing different salts. [104] The salt ion-dependent interaction with the passivation layer controlled the reaction between water and Mg resulting in velocities of around 109 and 75 µm s −1 when minimum concentrations of sodium chloride (0.03 m) and sodium carbonate (0.05 m) salts, respectively, were used. This type of micromotor might have potential in collection of precious metals from solution due to their high affinities toward Pt 2+ and Ag + .…”

Section: Disintegrating Nano/micromotorsmentioning

confidence: 99%

Recent Advances in Nano‐ and Micromotors

Fernández-Medina

Ramos-Docampo

Hovorka

et al. 2020

Adv Funct Materials

163

143

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Nano‐ and micromotors are fascinating objects that can navigate in complex fluidic environments. Their active motion can be triggered by external power sources or they can exhibit self‐propulsion using fuel extracted from their surroundings. The research field is rapidly evolving and has produced nano/micromotors of different geometrical designs, exploiting a variety of mechanisms of locomotion, being capable of achieving remarkable speeds in diverse environments ranging from simple aqueous solutions to complex media including cell cultures or animal tissue. This review aims to provide an overview of the recent developments with focus on predominantly experimental demonstrations of the various motor designs developed in the past 24 months. First, externally driven motors are discussed followed by considering fuel‐driven approaches. Finally, a short future perspective is provided.

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Section: Disintegrating Nano/micromotorsmentioning

confidence: 99%

Recent Advances in Nano‐ and Micromotors

Fernández-Medina

Ramos-Docampo

Hovorka

et al. 2020

Adv Funct Materials

163

143

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“…These concentrations were based on previous reports [8, 13]. Prior to quantitative analysis of MMP gene and protein expression, the potential cytotoxicity of the glucosamine sulfate treatment was examined.…”

Section: Resultsmentioning

confidence: 99%

Glucosamine sulfate suppresses the expression of matrix metalloproteinase-3 in osteosarcoma cells in vitro

Pohlig

Ulrich

Lenze

et al. 2016

BMC Complement Altern Med

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BackgroundGlucosamine, a common dietary supplement, has a possible anti-sarcoma effect. However, an understanding of the underlying mechanism of such an effect is limited. For this study we hypothesized that glucosamine suppresses the basal level of matrix metalloproteinase expression in human osteosarcoma cell lines.MethodsWe examined the osteosarcoma cell lines, MG-63 and SaOS-2. Cells were exposed to 0, 10, 50 and 100 μg/ml glucosamine sulfate for 48 h and treatment toxicity was determined through measurement of cell viability and proliferation. Relative gene expression of matrix metalloproteinase (MMP)-2, -3 and -9 was quantified by real-time polymerase chain reaction. Protein levels of MMP-2 and -9 were assessed by ELISA.ResultsAdministration of 10, 50 or 100 μg/ml glucosamine sulfate had no effect on the cell viability of MG-63 and SaOS-2 cells. A significant reduction of MMP expression in both cell lines was observed only for MMP-3, while a decrease in MMP-9 was seen in SaOS-2 cells. The expression of MMP-2 was not significantly affected in either cell line. Protein level of MMP-3 was reduced in both cell lines upon stimulation with 10 μg/ml glucosamine sulfate whereas for MMP-9 a decrease could only be observed in SaOS-2 cells.ConclusionIn this study, we found a pronounced suppressive effect of glucosamine sulfate particularly on MMP-3 and also MMP-9 mRNA and protein levels in osteosarcoma cell lines in vitro. The data warrants further investigations into the potential anti-tumor efficacy of glucosamine sulfate in osteosarcoma.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1315-6) contains supplementary material, which is available to authorized users.

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“…Chitin and chitosan oligomers (COS) are known to have antitumor activities (Suzuki et al, 1986;Zhang et al, 2006;Azuma et al, 2015b). COS (3 kDa<MW<5 kDa) was suggested to have chemopreventive activity in colon cancer by increasing the activities of quinone reductase (QR), and glutathione-S-transferase (GST), enhancing glutathione (GSH) levels, and inhibiting ornithine decarboxylase (ODC) activity and cyclooxygenase (COX)-2 expression in HT-29 cells (Nam et al, 2007).…”

Section: Anti-tumor Activitymentioning

confidence: 99%

Utilization of marine by-products for the recovery of value-added products

Shahidi¹,

Varatharajan²,

Han³

et al. 2019

JFB

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The world fisheries resources have exceeded 160 million tons in recent years. However, every year a considerable amount of total catch is discarded as by-catch or as processing leftovers, and that includes trimmings, fins, frames, heads, skin, viscera and among others. In addition, a large quantity of processing by-products is accumulated as shells of crustaceans and shellfish from marine bioprocessing plants. Recognition of the limited marine resources and the increasing environmental pollution has emphasized the need for better utilization of the by-products. Marine by-products contain valuable protein and lipid fractions, minerals, enzymes as well as many other components. The major fraction of by-products are used for feed production-in making fish meal/oil, but this has low profitability. However, there are many ways in which the fish and shellfish waste could be better utilized, including the production of novel food ingredients, nutraceuticals, pharmaceuticals, biomedical materials, fine chemicals, and other value-added products. In recent times, much research is conducted in order to explore the possible uses of different by-products. This contribution primarily covers the characteristics and utilization of the main ingredients such as protein, lipid, chitin and its derivatives, enzymes, carotenoids, and minerals originating from marine by-products.

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Antitumor activities of D-glucosamine and its derivatives

Cited by 26 publications

References 25 publications

Recent Advances in Nano‐ and Micromotors

Recent Advances in Nano‐ and Micromotors

Glucosamine sulfate suppresses the expression of matrix metalloproteinase-3 in osteosarcoma cells in vitro

Utilization of marine by-products for the recovery of value-added products

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