Antitumor‐active substances from mushrooms

Mizuno, Takashi; Saitô, Hazime; Nishitoba, Tsuyoshi; Kawagishi, Hirokazu

doi:10.1080/87559129509541018

Cited by 163 publications

(124 citation statements)

References 115 publications

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“…In recent years, A. auricula was reported to have many biological activities, including anticoagulant activity (Yoon et al 2003), antitumor activity (Mizuno et al 1995), hypoglycemia (Takeuchi et al 2004) and hypocholesterolemia (Cheung 1996). Up to now, considerable attention of A. auricula has been focused on dietary fiber and polysaccharide components, mainly extracted from its fruiting body.…”

Section: Introductionmentioning

confidence: 99%

Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice fed a cholesterol-enriched diet

Gang

Luo

et al. 2010

J Food Sci Technol

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The cholesterol-lowering properties of Auricularia auricula are commonly attributed to the presence of polysaccharides based on previous research. The present study was designed to investigate the effects of ethanol extract of A. auricula (AAE) on hypercholesterolemia in ICR mice. AAE contained more than 16% (g/g) polyphenolic compounds, excluding other interfering factors such as polysaccharides, water-soluble fibre and protein. Thirtysix mice were randomly assigned to three groups (n=12). The experimental group was fed cholesterol-enriched diet (CED) with oral administration of AAE (150 mg/kg/d b.w.) for 8-week, normal control group and CED control group received either a regular diet (RD) or CED along with oral administration of equal volume distilled water. Serum lipid profiles and antioxidant status were measured in addition to fecal neutral cholesterol and bile acids. AAE showed a remarkable hypocholesterolemic effect, improving antioxidant status, decreasing the level of total cholesterol and atherosclerosis index, increasing the level of high-density lipoprotein cholesterol and fecal excretion of bile acids. No apparent effects on serum triglycerides, low-density lipoprotein cholesterol, fecal excretion of neutral cholesterol and feeding efficiency were observed among all groups. These results indicated that A. auricula functional components, which prevented hypercholesterolemia contained polyphenolic compounds, in addition to polysaccharides.

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Section: Introductionmentioning

confidence: 99%

Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice fed a cholesterol-enriched diet

Gang

Luo

et al. 2010

J Food Sci Technol

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“…However, obvious variations of antitumor polysaccharides have also been reported, such as -glucan, 4,5) and -glucan protein. 6) Shida 7) et al have isolated an -heterogalactan and (1 ! 3)--D-glucan from the fruiting bodies of Lentinus edodes by extraction with 3% trichloroacetic acid and 1 M aqueous NaOH respectively.…”

mentioning

confidence: 99%

Antitumor Activities ofO-Sulfonated Derivatives of (1→3)-α-D-Glucan from DifferentLentinus edodes

Surenjav

Zeng

et al. 2006

Bioscience, Biotechnology, and Biochemistry

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“…passiflorae foi inibida pelas frações IV, V e VII. Desta forma, demonstrou-se que os isolados de L. edodes produzem compostos que apresentam atividade antifúngica e antibacteriana contra fitopatógenos, que estão principalmente concentrados na fração V. (14). The lentinan, a b-(1→3)-D-glucan extracted from L. edodes, showed antitumor, antibacterial, antiviral and anticlotting activities (7).…”

Section: Introductionunclassified

“…In vitro antimicrobial activity of aqueous extracts from Lentinula edodes isolates against Colletotrichum sublineolum and Xanthomonas axonopodis pv. passifloraeSumma Phytopathologica, v.41, n.1, p. [13][14][15][16][17][18][19][20]2015.…”

Section: In Vitro Antimicrobial Activity Of Aqueous Extracts Frommentioning

confidence: 99%

In vitro antimicrobial activity of aqueous extracts from Lentinula edodes isolates against Colletotrichum sublineolum and Xanthomonas axonopodis pv. Passiflorae

2015

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The aim of this study was to evaluate the antimicrobial activity of aqueous extracts from fruiting bodies of different isolates of Lentinula edodeson the pathogens Colletotrichum sublineolum, the causal agent of anthracnose in sorghum, and Xanthomonas axonopodispv. passiflorae, the causal agent of bacterial spot in passion fruit. Results showed that the aqueous extracts from isolates LE JAB-K and LE 95/01 significantly reduced C. sublineolumspore germination,while the isolate LE 96/22 was the only one to inhibit the pathogen mycelial growth. However, all L. edodesisolates showed inhibitory effect on C. sublineolumappressorium formation. Regarding X. axonopodispv. passiflorae, the aqueous extracts from all L. edodesisolates significantly reduced the in vitromultiplication of the bacterium. However, antimicrobial activity was lost when the extracts were autoclaved, demonstrating their thermolabile property. The aqueous extract from isolate LE 96/22 was also partially purified by anion exchange chromatography and fraction V exhibited high inhibitory activity on the in vitromycelial growth of C. sublineolum, while the multiplication of X. axonopodispv. passifloraewas inhibited by fractions IV, V and VII. Thus, L. edodesisolates were shown to produce compounds exhibiting antifungal and antibacterial activities against phytopathogens, which are mainly concentrated in fraction V.

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Antitumor‐active substances from mushrooms

Cited by 163 publications

References 115 publications

Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice fed a cholesterol-enriched diet

Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice fed a cholesterol-enriched diet

Antitumor Activities ofO-Sulfonated Derivatives of (1→3)-α-D-Glucan from DifferentLentinus edodes

In vitro antimicrobial activity of aqueous extracts from Lentinula edodes isolates against Colletotrichum sublineolum and Xanthomonas axonopodis pv. Passiflorae

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