Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids

Azorella trifurcata and Mulinum echegarayii obtained from central region of<br>Argentina: antibacterial activity of their organic extracts

“…An interesting group of bioactive metabolites, such as triterpenoids and diterpenoids with azorellane and mulinane skeletons have been obtained from Azorella, and Mulinum genera (Borquez et al,2011;Chiaramello et al, 2003a;Colloca et al,2004;Molina-Salinas et al,2010;Morales et al, 2003;Areche et al, 2009). So, some authors demonstrated that these metabolites display a wide variety of biological activities, including antimycobacterial activity (Molina-Salinas et al, 2010), trichomonicidal activity (Loyola et al, 2001), trypanocidal activity (Araya et al, 2003) and antiplasmodial activity (Loyola et al, 2004). To our knowledge, there are few reports available in the literature on activity of organic extracts of M. echegarayii and Azorella trifurcata against pathogenic bacteria tested in this study.…”

7-6-5 Tricarbocyclic Diterpenes

“…Azorellanes [14,20,[38][39][40][41][42][43][44][45][46][47][48][49][50] These compounds do not present a functionalized C-20 but in C-13 is always present an oxygenated functionality. Mulinanes show a great variety of A. compacta Antibacterial [33] 11,14-Dioxo-mulin12en-20-oic acid, 47…”

Synthesis of Mulinane Diterpenoids

“…27 Additionally, a pair of reports indicate that these secondary metabolites and synthetic derivatives thereof are potential antitubercular agents. 7,8 Other studies of bioactivity have appeared. 18,22−24 Structurally, the mulinanes are similar to the cyathane family of natural products in that they comprise a tricyclic array of fused five-, six-, and seven-membered rings with an angular substituent at each of the ring fusions (see Figure 1).…”