Antitoxin nanoparticles: design considerations, functional mechanisms, and applications in toxin neutralization

Desai, Nimeet; Pande, Shreya; Salave, Sagar; Singh, Thakur Raghu Raj; Vora, Lalitkumar K.

doi:10.1016/j.drudis.2024.104060

Drug Discovery Today

2024

DOI: 10.1016/j.drudis.2024.104060

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Antitoxin nanoparticles: design considerations, functional mechanisms, and applications in toxin neutralization

Nimeet Desai,

Shreya Pande,

Sagar Salave

et al.

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2024

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Cited by 1 publication

References 115 publications

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Achieving Endo/Lysosomal Escape Using Smart Nanosystems for Efficient Cellular Delivery

Desai,

Rana,

Salave

et al. 2024

Molecules

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The delivery of therapeutic agents faces significant hurdles posed by the endo-lysosomal pathway, a bottleneck that hampers clinical effectiveness. This comprehensive review addresses the urgent need to enhance cellular delivery mechanisms to overcome these obstacles. It focuses on the potential of smart nanomaterials, delving into their unique characteristics and mechanisms in detail. Special attention is given to their ability to strategically evade endosomal entrapment, thereby enhancing therapeutic efficacy. The manuscript thoroughly examines assays crucial for understanding endosomal escape and cellular uptake dynamics. By analyzing various assessment methods, we offer nuanced insights into these investigative approaches’ multifaceted aspects. We meticulously analyze the use of smart nanocarriers, exploring diverse mechanisms such as pore formation, proton sponge effects, membrane destabilization, photochemical disruption, and the strategic use of endosomal escape agents. Each mechanism’s effectiveness and potential application in mitigating endosomal entrapment are scrutinized. This paper provides a critical overview of the current landscape, emphasizing the need for advanced delivery systems to navigate the complexities of cellular uptake. Importantly, it underscores the transformative role of smart nanomaterials in revolutionizing cellular delivery strategies, leading to a paradigm shift towards improved therapeutic outcomes.

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Achieving Endo/Lysosomal Escape Using Smart Nanosystems for Efficient Cellular Delivery

Desai,

Rana,

Salave

et al. 2024

Molecules

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Antitoxin nanoparticles: design considerations, functional mechanisms, and applications in toxin neutralization

Cited by 1 publication

References 115 publications

Achieving Endo/Lysosomal Escape Using Smart Nanosystems for Efficient Cellular Delivery

Achieving Endo/Lysosomal Escape Using Smart Nanosystems for Efficient Cellular Delivery

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