Antitoxic Effects of Curcumin against Obesity-Induced Multi-Organs’ Biochemical and Histopathological Abnormalities in an Animal Model

Abstract

Background. Obesity is a significant public health problem that is characterized by an increase in oxidative stress and enhanced inflammatory responses associated with immune cell invasion of adipose tissues. This study assessed several biochemical abnormalities, apoptosis, oxidative stress status, and associated histological changes in the liver, duodenum, and heart brought on by high-fat diet-induced obesity in rats. It also assessed the mechanistic benefits of curcumin in reversing these inflammatory, metabolic, and histological impairments. Methods. Rats were assigned into three groups each including ten rats: the control group (CD), the high-fat diet group (HFD), and the high-fat diet + curcumin (HFDC) group. Serum glucose, insulin, and triglycerides (TAGs) were observed. In addition, apoptosis (indicated by hepatic DNA fragmentation) and oxidative stress status (indicated by hepatic MPO, GSH, and SOD) were assessed. Histopathological examinations included the GIT (liver and duodenum) and heart in addition to quantitative real-time polymerase chain reaction (qRT-PCR) assays of the adipose tissue genetic expressions for inflammatory signaling pathways (TLR4, IL-6, and TNF-α). Results. The overall findings showed that the HFD group exhibited significantly higher levels of glucose, TAGs, and insulin than the control group ( P < 0.01 ). The histological abnormalities of the studied organs in the HFD group were paralleled by these biochemical abnormalities, which were strongly associated with increased apoptosis, increased oxidative stress, and increased expression of the inflammatory signaling markers. There were significant improvements in the HFDC group in terms of biochemical, inflammatory, and histological investigations. Conclusions. This study’s findings concluded that obesity is significantly associated with biochemical and microscopic alterations in many organs. Curcumin exerted potent antitoxic, antioxidant, tissue-protective, and antiobesity effects. Curcumin is recommended to be added to various dietary regimens to prevent or delay the organs’ dysfunction among obese people.

Childhood obesity and curcumin: a possible effective anti-obesity adjunct

“…Hassan et al 36 who conducted a recent mechanistic study concluded curcumin does have the ability to exert potent antitoxic, anti-oxidant, tissue-protective, and anti-obesity effects, hence they recommended curcumin be added to various dietary regimens to prevent or delay organ dysfunction among obese people. Tsuda et al 37 similarly agree that curcumin has anti-obesity/anti-adipogenic and anti-diabetes biological properties among others, as also observed by Labban et al 38 and can be seen to have a high probability of preventing or reducing the magnitude of various obesity states through well defined biochemical signaling pathways and others that may be active even on preadipocytes, 39 as well as in reversing or modulating age and obesity associated metabolic diseases.…”

“…Schematic representation of possible benefits of curcumin supplementation in cases of intractable obesity or those at risk for obesity. 4,33,[35][36][37]40,42,56,57…”

Antibacterial activity and sustained release properties of curcumin-loaded chitosan microspheres/nanofiber composites membranes for wound healing applications

“…Based on its good dispersibility, it can enter the interior of bacteria and react with their enzymatic and biofilm systems. [27][28][29] The lipids of cell membranes have hydrophobic alkyl chains and hydrophilic polar groups, while curcumin, which has a phenolic ester structure, is not readily soluble in water and has hydrophilic groups and hydrophobic alkyl chains too, so it can dynamically reside in biological membranes and directly and rapidly disrupt the membrane structure and interfere with the energy metabolism of cells and organelles. 30 Because it is located in the cell membrane, it is hard to be decomposed by microbial enzymes, so it can achieve a lasting effect of inhibiting bacterial activity.…”

Curcumin as a Potential Antioxidant in Stress Regulation of Terrestrial, Avian, and Aquatic Animals: A Review

“…Antioxidants 2023, 12, x FOR PEER REVIEW 2 of 33 has been found to prevent organ dysfunction and is recommended as a dietary supplement for obese individuals [8]. Related to counteracting the oncogenic stress management system, curcumin not only causes the death of different Kaposi's sarcoma-associated herpes virus KSHV-positive cells but also obstructs the development of KSHV-infected cells [9].…”

“…Curcumin has shown promise in mitigating the adverse effects of combatting neurodegenerative disorders, making it effective in the treatment of Alzheimer’s disease [ 7 ]. Moreover, curcumin has been found to prevent organ dysfunction and is recommended as a dietary supplement for obese individuals [ 8 ]. Related to counteracting the oncogenic stress management system, curcumin not only causes the death of different Kaposi’s sarcoma-associated herpes virus KSHV-positive cells but also obstructs the development of KSHV-infected cells [ 9 ].…”