Antitissue Antibodies in Chronic Pancreatitis

Abstract

Organ- and nonorgan-specific autoantibodies (AA) have been investigated in 49 patients affected by alcoholic or idiopathic chronic pancreatitis (CP) to evaluate their prevalence and correlation with the clinical features of the disease. AA have been found in about 50% of CP and their recurrence rate was similar to that of alcoholic or cryptogenic liver cirrhosis (LC); age- and sex-matched healthy subjects (C) showed only about 8% positive sera (C vs. CP, p < 0.001). Quite different IFL patterns between CP and LC have been detected. Antibrush border, antireticulin and antigastric parietal cell antibodies alone or combined prevailed in CP, while antinuclear and antismooth muscle AA prevailed in LC. No correlation with sex, age, etiology, presence of pancreatic stones, diabetes, symptoms and years of CP was found for one or more AA. In conclusion, the detection of AA in CP is a quite common finding of still unclear clinical significance.

Μελετη Ενωσεων Με Βιολογικη Δραση Αναλογη Του Paf Και Αναστολεων Του Paf Ζωικης Φυτικης Και Συνθετικης Προελευσης

“…Τέλος, χορήγηση PAF στην άνω παγκρεατοδωδεκαδακτυλική αρτηρία κουνελιών έχει σαν αποτέλεσμα δοσοεξαρτώμενες μορφολογικές αλλοιώσεις όπως οίδημα, νέκρωση και πολυμορφοπυρηνική διήθηση παγκρεατικού ιστού και αύξηση της αμυλάσης του ορού (χαρακτηριστικά οξείας παγκρεατίτιδας) ( Emanuelli, G. et al 1989 ).…”