Antithyroid drugs

Probing the adsorption mechanism in thiamazole bound to the silver surface with Surface-enhanced Raman Scattering and DFT

“…Here we study thiamazole that depresses the formation of thyroid hormone by inhibiting hormonal biosynthesis with the incorporation of oxidized iodines into tyrosine residues in the large thyroid hormone precursor molecule, thyroglobulin [20]. Thiamazole is an important anti-thyroid drug and is used in the treatment of hyperthyroidism, i.e.…”

The accumulation of [35S]methimazole by human and rat lymphocytes

“…Only occasional evidence of accumulation was seen in PBL and thyroid derived lymphocytes of patients undergoing surgery for Graves' disease although the thyroid gland did accumulate radioactivity ('Marchant et al 1978). Lymphocytes from peripheral blood and thyroid from one patient were examined for their ability to form immuno¬ globulins by a haemolytic plaque assay (Gronowicz et al 1976).…”

“…Whether this 35S concentration represents native drug or MMI metabolites is not clear but in view of the known differences in MMI metabolism between rat and man (Marchant et al 1978) it is more probable that it represents 35S04 retention in the lymphocyte. MMI has been shown to reduce thyroid antibody levels in rats with thyroiditis (Keast et al 1981).…”

Nitrosyl iron complexes with enhanced NO donating ability: synthesis, structure and properties of a new type of salt with the DNIC cations [Fe(SC(NH2)2)2(NO)2]+

“…21,28 Variation of functional sulfur-containing ligands (R) in the synthetic models of [1Fe-2S] and [2Fe-2S] proteins, and of the synthesis conditions provides more thorough fundamental knowledge of the structure of the {RS 2 Fe(NO) 2 } unit, 25,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] while the investigation of the pharmacological activity of these compounds, in addition to the known NO properties, opens the possibilities for practical application of mimetics of nitrosyl non-heme proteins as effective NO-generating compounds for the therapy of socially significant diseases. [45][46][47][48][49][50][51][52] In the present work, thiocarbamide having a wide range of biological activity, including antituberculosis, antibacterial 53,54 and antithyroid 55 properties, was used as a functional sulfurcontaining ligand. Besides, the thiocarbamide molecule has a complex resonance structure, and in the solution the equilibrium can shift either to the thiol or thione form depending on the acidity, this being responsible for structural variety of this ligand and the related complexes.…”