Antithyroid drug regimen for treating Graves' hyperthyroidism

Favorable Effect of Bromocriptine and Pentoxifylline in Mild Graves Disease Orbitopathy: A Randomized, Open, Clinical Trial

“…To minimize side effects and improve tolerance, PTX and BRC were titrated over a two-week period. Throughout the study, a block-replace regimen was used adding levothyroxine in order to maintain euthyroidism [16].…”

“…In OD from 20 [18][19][20][21] to 18 [16][17][18] mm (p= 0.006), and in OS from 20 [19][20] to 18 [16][17][18] mm (p= 0.006). Proptosis also decreased with PTX treatment; however, this was significant only in OS.…”

“…Proptosis also decreased with PTX treatment; however, this was significant only in OS. In OD decreased from 19 [17.5-19] to 16.5 [16][17][18][19] mm (p= 0.120) and in OS from 19 [17.5-19] to 17 [16][17][18][19][20] mm (p= 0.025). In contrast, the group treated only with MTZ showed no change in proptosis.…”

“…In contrast, the group treated only with MTZ showed no change in proptosis. In OD from 19 [18][19][20] to 19 [16.5-19] mm (p= 0.173), and in OS from 18 [16][17][18][19] to 18 [16][17][18][19][20] mm (p= 0.942). These results are depicted in figure 2.…”

“…Besides the well-known roles of prolactin (PRL) in reproduction and lactation, it also functions as a cytokine implicated in the immune response [16]. Lymphocytes and other immune cells express both PRL and the PRL receptor.…”