Antithyroid antibodies in antiphospholipid syndrome: prevalence and clinical associations

Mavragani, C P; Danielides, Stamatina; Ζιντζαράς, Ηλίας; Vlachoyiannopoulos, P.; Moutsopoulos, H. M.

doi:10.1177/0961203309106763

Cited by 19 publications

(16 citation statements)

References 15 publications

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“…Antibodies to thyroid microsomal [2] and myeloperoxidase (MPO) are associated with graves’ disease and thyroiditis [3], antinuclear antibodies (ANA) and rheumatoid factor(RF) represent a serology hallmark in the diagnosis of systemic autoimmune rheumatic disease (SARD) such as systemic lupus erythematosus [4]. Zona pellucida antibodies are associated with POI, antibodies to double-stranded DNA (ds-DNA), histone, nuclear ribonucleoprotein (RNP) and Smith antigen [5] are associated with SLE, whereas antibodies to Sjogren’s syndrome A (SSA/Ro) and Sjogren’s syndrome B(SSB/La) can occur in both SLE and Sjogren’s syndrome (SS).…”

Section: Introductionmentioning

confidence: 99%

Serologic autoimmunologic parameters in women with primary ovarian insufficiency

Zhang

Qiao

et al. 2014

BMC Immunol

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BackgroundPrimary ovarian insufficiency (POI) is heterogeneous disease defined by amenorrhea or premature depletion of ovarian follicles before the age of 40 years. The etiology of POI is still unclear. The purpose of this study is to evaluate whether women with POI have an elevated serum levels of autoimmunologic parameters.MethodsThe serum from peripheral blood samples which come from 96 POI patients and 100 age-matched health women were analyzed for a series of autoimmune antibodies using protein microarray. The antibodies to double-stranded DNA (ds-DNA), histone (HIS), nuclear ribonucleoprotein (RNP), Sjogren’s syndrome A (SSA/Ro), Sjogren’s syndrome B (SSB/La) and Smith antigen, Jo-1, scleroderma-associated antigen (Scl-70) and centromere (CEN), zona pellucid (ZP), adrenocortical antibodies (ACA),Rheumatoid factor (RF), glomerular basement membrane (GBM), proliferating cell nuclear antigen (PCNA), myeloperoxidase (MPO), proteinase 3 (PR3), thyroid microsomal antibody and antinuclear antibody (ANA)were analyzed.ResultsAmong the 96 women with POI and 100 age-matched health controls, women with POI had significantly elevated circulation levels of Jo-1 and PR3 (p = 0.010 and p = 0.001) whereas circulation levels of ANAs, dsDNA, histone, RNP, Sm, Scl-70, SSA, SSB, CEN, ZP, ACA, RF, GBM, PCNA, MPO and TM antibodies were similar between the two groups.ConclusionsThis study shows that the autoimmune antibodies JO-1 and PR3 were significantly higher in POI women group which suggested that these antibodies may have played special role in POI, but the evaluation of the exact pathways of them remains to be determined.

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Section: Introductionmentioning

confidence: 99%

Serologic autoimmunologic parameters in women with primary ovarian insufficiency

Zhang

Qiao

et al. 2014

BMC Immunol

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“…Results from the study by Mavragani et al showed that patients with APS (primary and secondary) are associated with antithyroid antibodies. 31 To date, our study is the first to report an association between APS and SLE patients with ATD. Further research on the underlying pathogenetic mechanisms is warranted, to allow better understanding in these autoimmune diseases.…”

Section: Discussionmentioning

confidence: 89%

Autoimmune thyroid disease in a cohort of Malaysian SLE patients: frequency, clinical and immunological associations

Ong

Choy

2015

Lupus

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Autoimmune thyroid disease (ATD) has been associated with other systemic autoimmune diseases. To date, there is limited data on thyroid disorders and autoimmune thyroid disease in Malaysia. The frequency of ATD among 189 systemic lupus erythematosus (SLE) patients was 6.3%, with 2.6% in the hyperthyroid group and 3.7% in the hypothyroid group. Hypothyroidism developed at a much younger mean age (24.3 years), suggesting that SLE might be a predisposing factor for the development of Hashimoto's thyroiditis. There was a higher rate of thyroid peroxidase antibody (TPO) positivity compared with anti-thyroglobulin antibody (Tg) in the hyperthyroid subgroup. This study also demonstrated a greater proportion of ATD patients who demonstrated high titres (≥ 1:6400) of TPO compared with high titres of Tg. Although there was an association between ATD and the presence of anti-Ro/SSA and/or anti-La/SSB antibodies, the absence of sicca symptoms and negative Schirmer's tests suggest a lack of association with secondary Sjogren's syndrome. A novel association between ATD and antiphospholipid syndrome (APS) was detected in our cohort. Hence we propose that patients affected by APS be routinely screened for ATD.

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“…Many of these series did not find any increase of antiphospholipid antibodies and antithyroid antibodies versus comparison groups [87][88][89]. One study found antithyroid antibodies in 27% of APS patients [90].…”

Section: Thyroid Involvement In Apsmentioning

confidence: 96%

“…Patients can have both antithyroid and antiphospholipid antibodies [77][78][79][80], including women with autoimmune thyroid disease [81][82][83][84][85][86][87][88][89]. Many of these series did not find any increase of antiphospholipid antibodies and antithyroid antibodies versus comparison groups [87][88][89].…”

Section: Thyroid Involvement In Apsmentioning

confidence: 98%

Review of Endocrine Manifestations of Antiphospholid Syndrome

Petri¹

2010

CRR

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Endocrine manifestations of the antiphospholipid syndrome (APS) are very rare. Adrenal insufficiency, surprisingly usually due to venous infarction, is the most common. It can even be the presenting manifestation of APS, occur in patients with transient antiphospholipid antibodies or even in a neonate through transplacental transfer of maternal antiphospholipid antibodies. The presentation, differential diagnosis, and treatment of adrenal involvement due to APS will be reviewed. Other even rarer endocrine manifestations will also be briefly discussed.

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Antithyroid antibodies in antiphospholipid syndrome: prevalence and clinical associations

Cited by 19 publications

References 15 publications

Serologic autoimmunologic parameters in women with primary ovarian insufficiency

Serologic autoimmunologic parameters in women with primary ovarian insufficiency

Autoimmune thyroid disease in a cohort of Malaysian SLE patients: frequency, clinical and immunological associations

Review of Endocrine Manifestations of Antiphospholid Syndrome

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