Antithyroid antibodies, cognition and instrumental activities of daily living in the elderly

Regal, Paul

doi:10.1002/gps.3767

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…Despite the above-presented reports, Regal mentioned that after the correction of data for multiple comparisons in the analysis of variance, no correlations were observed between titres of anti-thyroglobulin and anti-thyroid peroxidase antibodies in the analysed cognitive tests [46].…”

Section: Prace Oryginalnementioning

confidence: 90%

Modele funkcji poznawczych względem wybranych parametrów stanu funkcjonalnego tarczycy u kobiet po menopauzie

Gujski

Pinkas

Witczak

et al. 2017

Endokrynologia Polska

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Introduction: The objective of the study was the development of models of cognitive functions in a group of post-menopausal women, according to the concentration of the selected laboratory parameters evaluating the functional state of the thyroid gland. Material and methods:The study was conducted during 2012-2014, and covered women aged 50-65 years, minimum two years after the last menstruation, without chronic diseases, cancerous diseases, mental disorders, addiction to drugs or alcohol, and who did not use hormone replacement therapy. At the stage of qualification, a brief MoCA test was performed; 383 women were qualified for the study. Blood was collected for the determination of such parameters as: TSH, TT4, fT4, anti-TPO, anti-Tg, and AB-TSHR. Assessment of cognitive functions was performed using the diagnostic instrument Central Nervous System -Vital Signs (CNS-VS) (Polish version). The results were statistically analysed.

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Section: Prace Oryginalnementioning

confidence: 90%

Modele funkcji poznawczych względem wybranych parametrów stanu funkcjonalnego tarczycy u kobiet po menopauzie

Gujski

Pinkas

Witczak

et al. 2017

Endokrynologia Polska

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“…Despite the information presented above, Regal states that after correcting the data for multiple comparisons in variance analysis, there was no correlation between denominations of thyroglobulin antibodies and thyroglobulin peroxidase antibodies in analyzed cognitive test [33]. …”

Section: Discussionmentioning

confidence: 99%

Functional Status of Thyroid and Cognitive Functions after Menopause

et al. 2015

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BackgroundThyroid activity plays a role in cognition. However, the relation between the functional state of thyroid and neuropsychiatric changes proceeding with age among people without clinical symptoms of thyroid dysfunction is still unknown. The aim of this study was analysis of cognitive function levels in reference to thyroid examination: thyroid-stimulating hormone (TSH), total thyroxin (TT4), triiodothyronine (TT3), free thyroxin (FT4), free triiodothyronine (FT3), thyroperoxidase antibodies (TPO-AB), and thyroglobulin antibodies (Tg-AB), TSH receptor antibodies (AB-TSHR) in women after menopause.Material/MethodsA group of 383 women was recruited for the study. The inclusion criteria were: minimum two years after the last menstruation and no dementia signs on Montreal Cognitive Assessment (MoCA). Computerized battery of Central Nervous System Vital Signs (CNS VS) test was used to diagnostic cognitive functions. The blood plasma values were determined: TSH, FT3, FT4, TT3, TT4, TPO-AB, Tg-AB, and AB-TSHR. Statistical analysis was performed using Pearson’s correlation coefficient and analysis of variance in STATISTICA software.ResultsIn women after menopause, TSH was negatively correlated with NCI results, executive functions, complex attention, and cognitive flexibility. FT4 was positively correlated with results of psychomotor speed. TT3 and TT4 were negatively correlated with results of memory and verbal memory. Furthermore, TT4 was negatively correlated with NCI, executive functions, and cognitive flexibility. TPO-AB was negatively correlated with results of memory, verbal memory, and psychomotor speed. Tg-AB was positively correlated with results of reaction time. AB-TSHR was negatively correlated with NCI results, memory, executive functions, psychomotor speed, complex attention, and cognitive flexibility.ConclusionsOur study supports the importance of thyroid functionality in cognitive functioning in a group of women after menopause. The values of TSH, TT3, TT4, TPO-AB, and AB-TSHR were higher and FT4 was lower in examined women. The results were poorer in examination of cognitive functions measured with a battery of CNS-VS tests.

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“…By contrast, in another study (n = 11, age range: 22‐82 years), euthyroid patients with higher anti‐TPO‐titers and Hashimoto's had better long‐term outcomes based on the Glasgow Outcome Scale Extended score 68 . Moreover, a large population‐based cross‐sectional study (n = 3253, age range: 55‐85 years), 69 as well as a prospective study on elderly population (n = 255, mean age:80 years), 70 showed no association between anti‐TPO seropositivity and cognitive decline, both at baseline and after 13 months of follow‐up.…”

Section: Autoimmunity Against Thyroid and Its Association With Cognitmentioning

confidence: 97%

The relation between thyroid dysregulation and impaired cognition/behaviour: An integrative review

Eslami‐Amirabadi

2021

J Neuroendocrinology

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Prevalence of cognitive impairment and dementia substantially increases with ageing, especially in the oldest old population. 1 Thyroid disorders are also prevalent in the elderly population, with the prevalence of hypo-and hyperthyroidism reaching 30% and 10% respectively. 2,3 It has been long noted that disorders of thyroid function can lead to cognitive impairment. Therefore, thyroid dysfunctions are important and potentially modifiable risk factors of cognitive impairment in the older individuals. 4 Thyroid dysfunctions can be categorised based on the serum levels of thyroid hormones (thyroxine [T4] and triiodothyronine [T3]) and thyroid-stimulating hormone (TSH) level as: overt hypothyroidism: decreased T4/T3 levels and increased TSH; overt hyperthyroidism: increased T4/T3 and decreased TSH; subclinical hypothyroidism: normal T4/T3 levels with increased TSH; and subclinical hyperthyroidism: normal T4/T3 levels and decreased TSH level. 4 The association of hypo-or hyperthyroidism with cognition and behaviour has been investigated in many experimental animal studies, 5-7 and also in human observational and experimental studies, as well as clinical trials. 8-11 The objectives of this review are: • To provide a summary of the spectrum of cognitive and behavioural impairments related to thyroid disorders

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Antithyroid antibodies, cognition and instrumental activities of daily living in the elderly

Cited by 5 publications

References 5 publications

Modele funkcji poznawczych względem wybranych parametrów stanu funkcjonalnego tarczycy u kobiet po menopauzie

Modele funkcji poznawczych względem wybranych parametrów stanu funkcjonalnego tarczycy u kobiet po menopauzie

Functional Status of Thyroid and Cognitive Functions after Menopause

The relation between thyroid dysregulation and impaired cognition/behaviour: An integrative review

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