Antithyroid Antibodies and Fertility Outcome in Euthyroid Women Undergoing In Vitro Fertilisation

Devi, Aheibam Bidya; Prasad, Sudha; Koner, Bidhan Chandra

doi:10.7860/jcdr/2019/40760.12872

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on these analyses, therefore, it is very unclear to what extent the older age of the TAI+ cohort contributed to the adverse reproductive outcomes that were observed. Thirdly, since the last meta-analysis, at least 4 further studies analysing women of known ages have been published [21][22][23][24]. Busnelli et al (2016) [6] included a total of 428 TAI+ women of known ages.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thyroid autoimmunity and IVF/ICSI outcomes in euthyroid women: a systematic review and meta-analysis

Venables

Wong

Way

et al. 2020

Reprod Biol Endocrinol

View full text Add to dashboard Cite

Background Thyroid autoimmunity (TAI) – the presence of anti-thyroid peroxidase and/or anti-thyroglobulin antibodies – affects 8–14% of reproductively-aged women. It is hotly debated whether TAI adversely affects IVF/ICSI outcomes. This systematic review and meta-analysis evaluated the relationship between thyroid autoimmunity (TAI) and IVF/ICSI outcomes, both overall and amongst euthyroid women of known age using strict criteria for grouping pregnancy outcomes. Methods The review was registered with PROSPERO: CRD42019120947. Searches were undertaken in MEDLINE, EMBASE, Web of Science and Cochrane Database from Inception-March 2020. Primary outcomes were clinical pregnancy rate, clinical miscarriage rate, biochemical pregnancy loss, livebirth rate per-cycle and live birth rate per clinical pregnancy (CP). Results 14 studies were included in the meta-analysis. Compared with women who tested negative for thyroid autoantibodies (TAI-), there was no significant difference in clinical pregnancy rate overall (OR 0.86; 95%CI [0.70, 1.05]; P = 0.14; 11 studies; I2 = 29.0%), or in euthyroid women (OR 0.88; 95%CI [0.69, 1.12]; P = 0.29; 10 studies; I2 = 32.0%). There was also no significant difference in clinical miscarriage rate overall (OR 1.04; 95%CI [0.52, 2.07]; P = 0.908; 8 studies; I2 = 53%), or in euthyroid women (OR 1.18; 95%CI [0.52, 2.64]; P = 0.69; 7 studies; I2 = 54%). There was no significant difference in biochemical pregnancy loss (OR 1.14; 95%CI [0.48, 2.72]; P = 0.769; 4 studies; I2 = 0.0%), live birth rate per cycle (OR 0.84; 95%CI [0.67, 1.06]; P = 0.145; I2 = 1.7%), live birth rate per clinical pregnancy (OR 0.67; 95%CI [0.28, 1.60]; P = 0.369; I2 = 69.2%), both overall and in euthyroid women as all studies included consisted of euthyroid women only. There was also no significant difference in number of embryos transferred, number of oocytes retrieved, mean maternal age or TSH levels overall or in euthyroid women. Conclusion The findings of the present study suggest that thyroid autoimmunity has no effect on pregnancy outcomes in euthyroid women alone, or in euthyroid women and women with subclinical hypothyroidism.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Busnelli et al (2016) [6] included a total of 428 TAI+ women of known ages. These 3 newer studies [21][22][23][24] contain an additional 390 TAI+ women.…”

Section: Introductionmentioning

confidence: 99%

Thyroid autoimmunity and IVF/ICSI outcomes in euthyroid women: a systematic review and meta-analysis

Venables

Wong

Way

et al. 2020

Reprod Biol Endocrinol

View full text Add to dashboard Cite

show abstract

“…After detailed evaluation of the remaining 27 articles, 6 studies were excluded because 2 articles involved people either with apparent hypothyroidism (Poppe et al, 2020) or with recurrent miscarriages (Bliddal et al, 2019); 4 studies without the criteria defining the positivity of TAI (Cai et al, 2019;Pekcan et al, 2019;Wang et al, 2017;Weghofer et al, 2016). As we defined TPO-Ab concentration >34 IU/mL or >100 IU/mL as threshold, 16 articles were excluded with: TPO-Ab threshold below 34 IU/mL in 6 articles (Andrisani et al, 2018;Caccavo et al, 2016;Chai et al, 2014;Litwicka et al, 2015;Medenica et al, 2018;Zhong et al, 2012); TPO-Ab threshold between 34 IU/mL and 100 IU/mL in 4 articles (Devi et al, 2019; F I G U R E 1 Study selection process for the meta-analysis of the effect of thyroid autoimmunity on assisted reproduction treatment outcomes. TG-Ab, thyroglobulin antibody; TPO-Ab, thyroid peroxidase antibody.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

“…After detailed evaluation of the remaining 27 articles, 6 studies were excluded because 2 articles involved people either with apparent hypothyroidism (Poppe et al, 2020) or with recurrent miscarriages (Bliddal et al, 2019); 4 studies without the criteria defining the positivity of TAI (Cai et al, 2019; Pekcan et al, 2019; Wang et al, 2017; Weghofer et al, 2016). As we defined TPO‐Ab concentration >34 IU/mL or >100 IU/mL as threshold, 16 articles were excluded with: TPO‐Ab threshold below 34 IU/mL in 6 articles (Andrisani et al, 2018; Caccavo et al, 2016; Chai et al, 2014; Litwicka et al, 2015; Medenica et al, 2018; Zhong et al, 2012); TPO‐Ab threshold between 34 IU/mL and 100 IU/mL in 4 articles (Devi et al, 2019; He et al, 2020; Kutteh et al, 1999; Muller et al, 1999); TG‐Ab included as indicator of TAI in 6 articles (Karacan et al, 2013; Kilic et al, 2008; Liu et al, 2020; Mintziori et al, 2014; Sakar et al, 2016; Tan et al, 2014). Finally, 7 papers published from 2003 to 2020, were included for our meta‐analysis (Figure 1) (Chen et al, 2017; Łukaszuk et al, 2015; Negro et al, 2005, 2007; Poppe et al, 2003; Unuane et al, 2016, 2017).…”

Section: Methodsmentioning

confidence: 99%

High level of thyroid peroxidase antibodies as a detrimental risk of pregnancy outcomes in euthyroid women undergoing ART: A meta‐analysis

Zhang

Yang

et al. 2023

Molecular Reproduction Devel

View full text Add to dashboard Cite

Thyroid autoimmunity (TAI) triggered by genetic and epigenetic variation occurs mostly in women of reproductive age. TAI is described mainly by positivity of anti‐thyroid peroxidase antibody (TPO‐Ab) and/or thyroglobulin antibody (TG‐Ab). TPO‐Ab, but not TG‐Ab, was suggested to be associated with pregnancy outcome in euthyroid women undergoing assisted reproductive technology (ART), but their results are conflicting. This meta‐analysis was performed to decide whether the presence of TPO‐Ab—in a concentration dependent manner—correlates with the success of ART. A systematic literature search was performed in the PubMed, Web of Science, and EMBASE databases for relevant articles published from January 1999 to April 2022, and these studies focused on the effect of TAI on pregnancy outcomes of women who underwent in vitro fertilization, intracytoplasmic sperm injection and intrauterine insemination and met the inclusion criteria: (i) the studies were prospective or retrospective study; (ii) all patients undergoing ART were tested for thyroid‐related antibodies; (iii) the assessed ART outcomes included miscarriage rate (MR) or delivery rate (DR). The exclusion criteria were: (i) female congenital uterine malformation, chromosomal diseases and other infectious diseases; (ii) overt hypothyroidism or pre‐existing thyroid disease; (iii) thrombus tendency. We divided the included patients into three groups according to the TPO‐Ab threshold they defined: (i) TPO‐Ab (−), threshold <34 IU/mL; (ii) TPO‐Ab‐34, threshold >34 IU/mL; (iii) TPO‐Ab‐100, threshold >100 IU/mL. We then extracted necessary relevant data, including MR and DR. Egger's test was used to evaluate the risk of publication bias. This meta‐analysis included a total of 7 literatures involving 7466 patients with TAI (−) and 965 patients with TAI (+) and revealed that there was no significant difference between group TPO‐Ab‐34 and group TPO‐Ab (−) in MR [risk ratio (RR): 0.61 (0.35, 1.08), p = 0.09] and DR [RR: 0.97 (0.83, 1.13), p = 0.69]. By contrast, compared to TPO‐Ab (−) group, TPO‐Ab‐100 patients showed markedly higher MR [RR: 2.12 (1.52, 2.96), p = 0.0046], and lower DR [RR: 0.66 (0.49, 0.88), p < 0.0001] with high degree of statistical significance. This meta‐analysis suggests that, for euthyroid patients, high level of TPO‐Ab (>100 IU/mL) could adversely influence the pregnancy outcome of ART.

show abstract

Impact of Thyroid Autoimmunity on Assisted Reproductive Technology Outcomes and Ovarian Reserve Markers: An Updated Systematic Review and Meta-Analysis

Busnelli

Beltratti

Cirillo

et al. 2022

Thyroid

View full text Add to dashboard Cite

Antithyroid Antibodies and Fertility Outcome in Euthyroid Women Undergoing In Vitro Fertilisation

Cited by 3 publications

References 0 publications

Thyroid autoimmunity and IVF/ICSI outcomes in euthyroid women: a systematic review and meta-analysis

Thyroid autoimmunity and IVF/ICSI outcomes in euthyroid women: a systematic review and meta-analysis

High level of thyroid peroxidase antibodies as a detrimental risk of pregnancy outcomes in euthyroid women undergoing ART: A meta‐analysis

Impact of Thyroid Autoimmunity on Assisted Reproductive Technology Outcomes and Ovarian Reserve Markers: An Updated Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About