Antithrombotic therapy in left ventricular thrombosis and systemic embolism

Cregler, Louis L.

doi:10.1016/0002-8703(92)91069-d

Cited by 63 publications

(31 citation statements)

References 37 publications

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“…Low levels of symptomatic systemic embolization were seen in this and other studies that demonstrated similar incidence (Visser et al, 1985;Johannessen et al, 1987;Keren et al, 1990). In a review, Cregler (1992) advocated 3 months of warfarin therapy for those with large anterior myocardial infarction or post-infarct heart failure. In all of the available literature, thrombus development was identified within 5 d of the index infarction and usually within 48 h. With current management of myocardial infarction, warfarinization of patients is no longer recommended.…”

Section: Comment On Guidelines On Oral Anticoagulation With Warfarin4supporting

confidence: 63%

Comment on Guidelines on oral anticoagulation with warfarin – 4th edition

Gosai¹,

Muthusamy²

2011

Br J Haematol

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(VDR)relativetoABL1transcript,andflowcytometrytostudythe apoptotic effect of VD. VD induced apoptosis of cultured lymphocytes in P prior to remission, but not in C or in P at relapse (Fig 1B, C). Response to VD correlated with VDR expression (Fig 1C). Pepper et al (2003) demonstrated that lymphocytes from CLL patients overexpress variable levels of VDR, and that an analog of 1-25(OH) 2 D 3 , can induce apoptosis of these cells in vitro. Our observations strongly suggest that these in vitro concepts may hold true in vivo, with VD supplementation at the conventional dose. This effect seems to be related to the level of VDR expression in lymphocytes. It could be speculated that patients with higher VDR levels could have the best response to VD therapy. Our late observations in P also suggest that VD resistance may also develop. A clinical trial is now needed to determine whether there is room for VD in the treatment of CLL.

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Section: Comment On Guidelines On Oral Anticoagulation With Warfarin4supporting

confidence: 63%

Comment on Guidelines on oral anticoagulation with warfarin – 4th edition

Gosai¹,

Muthusamy²

2011

Br J Haematol

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“…Most clinicians cite ST-segment elevation lasting more than three months, past the onset of AMI as a strong indication for aneurysm. 6 The infarction is almost always electrocardiographically obvious, with significant Q waves and loss of the R wave in the leads with ST-segment elevations. Although the mechanism of such ST displacement is not fully understood, persistent ST-segment elevation in patients with MI generally is considered the most helpful sign of ventricular aneurysm.…”

Section: Discussionmentioning

confidence: 99%

Clinical Pearls: Left Leg Pain and Electrocardiographic ST‐segment Elevation

Filley

1999

Academic Emergency Medicine

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“…It is commonly acknowledgd that LV thrombus formation is the major source of embolic stroke after ST-elevated myocardial infarction, 1,26 Data on embolic risk in patients with LV thrombus varies. [2][3][4][5]11,[27][28][29] However, most embolic events occur in the first 4 months after myocardial infarction. 4,12,29 Thus, the intrinsic properties of the thrombus change with aging: the older thrombus is more fixed to the LV wall and less fragile because of its collagen-rich organization.…”

Section: Thrombus After Myocardial Infarctionmentioning

confidence: 99%

“…2,11,29 A report of 43 patients with LV thrombus after myocardial infarction who were followed for a mean of 15 months states no embolic event in the 25 patients treated with anticoagulation, in comparison with 7 reports of embolic events in the untreated patients-all occurring within the first 4 months. 12 Thus, in the 2006 American Heart Association/American Stroke Association guidelines for prevention of ischemic stroke full anticoagulation was recommended for 3 months up to 1 year in patients with myocardial infarction and consecutive LV thrombi.…”

Section: Thrombus Resolution With Phenprocoumonmentioning

confidence: 99%