Antithrombotic therapy in elderly patients with atrial fibrillation: effects and bleeding complications: a stratified analysis of the NASPEAF randomized trial

Abstract

The elderly with AF had a higher event-rate than the younger patients. A higher severe bleeding event-rate was also registered in elderly patients receiving anticoagulant therapy. Combined, compared with anticoagulant therapy, significantly reduced vascular events and bleeding mortality in elderly patients.

Analysis of antithrombotic therapy in elderly patients with atrial fibrillation

“…Most of the elderly patients with AF have an intermediate or high risk of stroke, and therefore the combination of antiplatelet or anticoagulant therapy should be given. The NASPEAF random test confirmed that the incidence of AF was significantly higher in patients older than 75 years compared to that of younger patients, and combined antiplatelet and anticoagulation therapy could significantly reduce the incidence of vascular events (Pérez-Gómez et al, 2007). Lip et al (2010) evaluated 1084 patients with AF based on the European Heart Survey with the CHA2DS2-VSAc score, confirming that the stroke incidence increased year by year as the integral age increased.…”

Combined anticoagulation and antiplatelet therapy for high-risk patients with atrial fibrillation: a systematic review

“…Three of these RCTs were supported by post hoc, subgroup or pooled analyses reported in a further six articles. [44][45][46][47][48][49] The characteristics of these studies and their quality assessment are reported in Tables 4 and 5, respectively, and in Appendix 6.…”

“…RCT SPAF III (n = 2) [48][49] RCT NASPEAF (n = 3) [44][45][46] RCT AFASAK II (n = 1) 47 Total included publications (n = 53)…”

“…39,40,41,54,63,64,65,73 a Supported by three subgroup analyses [44][45][46] of the same population (on same intervention and comparators). of the same population (on same intervention and comparators).…”

“…prior TE), female and age > 75 years. [44][45][46] of the same population (on same intervention and comparators).…”