Antithrombotic therapy after angioplasty of pulmonary vein stenosis due to atrial fibrillation ablation: A two‐center experience and review of the literature
Abstract:Background
Pulmonary vein stenosis (PVS) is a severe complication of atrial fibrillation (AF) ablation resulting in narrowing of affected pulmonary veins (PVs). Interventional treatment consists of angioplasty with or without PV stenting. The optimal postprocedural antithrombotic therapy is not known.
Study aims
To investigate the impact of antithrombotic medical therapy on recurrence of PVS after PV angioplasty.
Methods
A retrospective study of patients undergoing PV angioplasty with or without stent implanta… Show more
“…However, it has been reported that the rate of restenosis in the chronic phase was lower in patients treated with triple therapy. 33 In the present cohort, only 1 patient received triple therapy. It is unclear whether these data are applicable to the Japanese population, which has a high incidence of bleeding events.…”
outcomes, to help establish optimal diagnostic and treatment procedures for this iatrogenic complication.
Methods
Study PatientsThis multicenter retrospective observational study was conducted at 3 cardiovascular centers in Japan (Saga University Hospital, Kokura Memorial Hospital, and Sagaken Medical Centre Koseikan). Thirty patients who were clinically indicated to undergo PV intervention for PVS or PV occlusion after AF ablation between 2010 and 2023 were enrolled in the study. Thirty paients with 56 lesions in 43 PV interventional procedures were analyzed retrospectively. PVS was defined as >75% stenosis or total occlusion evaluated by contrast-enhanced computed tomography (CT). The clinical indications for PV intervention were D ue to the aging population in Japan, the number of patients with atrial fibrillation (AF) is increasing rapidly. 1,2 Catheter ablation, mainly pulmonary vein (PV) isolation, is actively performed to maintain sinus rhythm. 3,4 However, severe PV stenosis has been reported (frequency 0.5-4.0%) as a serious complication of catheter ablation in the chronic phase, and can be fatal if not treated appropriately. 5-8 Percutaneous PV intervention is a treatment option for PV stenosis (PVS), but the diagnostic and treatment procedures have not yet been established due to the limited number of reported cases in Japan. 9 The number of catheter ablation cases in Japan is increasing every year, 2 and PV intervention for PVS is predicted to increase in the future. The aim of the present study was to investigate and describe data on PV intervention for PVS from a multicenter registry, including patient background, interventional procedures, and long-term
“…However, it has been reported that the rate of restenosis in the chronic phase was lower in patients treated with triple therapy. 33 In the present cohort, only 1 patient received triple therapy. It is unclear whether these data are applicable to the Japanese population, which has a high incidence of bleeding events.…”
outcomes, to help establish optimal diagnostic and treatment procedures for this iatrogenic complication.
Methods
Study PatientsThis multicenter retrospective observational study was conducted at 3 cardiovascular centers in Japan (Saga University Hospital, Kokura Memorial Hospital, and Sagaken Medical Centre Koseikan). Thirty patients who were clinically indicated to undergo PV intervention for PVS or PV occlusion after AF ablation between 2010 and 2023 were enrolled in the study. Thirty paients with 56 lesions in 43 PV interventional procedures were analyzed retrospectively. PVS was defined as >75% stenosis or total occlusion evaluated by contrast-enhanced computed tomography (CT). The clinical indications for PV intervention were D ue to the aging population in Japan, the number of patients with atrial fibrillation (AF) is increasing rapidly. 1,2 Catheter ablation, mainly pulmonary vein (PV) isolation, is actively performed to maintain sinus rhythm. 3,4 However, severe PV stenosis has been reported (frequency 0.5-4.0%) as a serious complication of catheter ablation in the chronic phase, and can be fatal if not treated appropriately. 5-8 Percutaneous PV intervention is a treatment option for PV stenosis (PVS), but the diagnostic and treatment procedures have not yet been established due to the limited number of reported cases in Japan. 9 The number of catheter ablation cases in Japan is increasing every year, 2 and PV intervention for PVS is predicted to increase in the future. The aim of the present study was to investigate and describe data on PV intervention for PVS from a multicenter registry, including patient background, interventional procedures, and long-term
“…We did not use the balloon devices for patients with a common PV trunk or right A lthough pulmonary vein isolation (PVI) has been established as a cornerstone treatment for atrial fibrillation (AF), 1 PV stenosis (PVS) after PVI remains a major complication requiring intervention and is associated with significant morbidity. [2][3][4][5] As the performance of wide encircling PVI using radiofrequency (RF) catheters spread around the world, the incidence of PVS has decreased. However, with the recent development of various balloon devices (e.g., cryoballoon [CB], hot balloon [HB], and laser balloon [LB]), PVS has increased again, because segmental PVI is required.…”
Background: Pulmonary vein stenosis (PVS) after PV isolation (PVI) for atrial fibrillation (AF) is a severe complication that requires angioplasty. This study aimed to compare the reduction of the cross-sectional PV area (PVA) and the incidence of PVS after cryoballoon (CB)-PVI, hot balloon (HB)-PVI, or laser balloon (LB)-PVI.
Methods and Results:A total of 320 patients who underwent an initial catheter ablation procedure for AF using a CB, HB, or LB in 2 hospitals were included. They underwent contrast-enhanced multidetector CT before and 3 months after the procedure. In all 4 PVs, the reduction in PVA was more significant in the LB group than in the CB or HB groups, respectively. Moderate (50-75%) and severe (>75%) PVS were observed in 5.3% and 0.5% of the PVs, respectively. Although moderate PVS was more frequently observed in the LB group than in the CB or HB groups (8.2%, 3.8%, and 5.0%; P=0.03), the incidence of severe PVS was similar in the LB, CB, and HB groups (0.3%, 0.5%, and 1.0%; P=0.46). Symptomatic PVS requiring intervention occurred in 1 (0.3%) patient.
Conclusions:Although the reduction in cross-sectional PVA and the incidence of moderate PVS after LB-PVI was more significant than after CB-PVI or HB-PVI, it rarely led to severe PVS. Symptomatic PVS requiring intervention was rare after the balloon ablation of AF.
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