“…Volume 100 was unusual in that it consisted of three parts dedicated respectively to research at the population level, the patient level and the basic level. The most downloaded articles over the period up to 2 years following publication were clinical reviews on ischaemia/reperfusion injury [2], drug eluting stents [3], antithrombotic strategies in non-valvular atrial fibrillation [4], endothelial function [5], and the use of positive pressure ventilation in the management of chronic heart failure [6] as well as original articles on the use of Sildenafil in the treatment of children with pulmonary hypertension [7], the MERCURY I trial which compared the hypolidaemic efficacy of switching between different statin regimes [8], and clinical and a basic science reports on the effect of endurance exercise training [9,10]. As previously, we saw a considerable interest concerning the potential of stem cell mobilisation in the treatment of chronic ischaemic heart disease [11].…”