Antithrombotic drugs are risk factors for delayed postoperative bleeding after endoscopic submucosal dissection for gastric neoplasms

Risk factors for bleeding after gastric endoscopic submucosal dissection: a systematic review and meta-analysis

“…25 Other clinical factors were analyzed in a few studies. Helicobacter pylori infection, 13,14,22 body mass index, 22,29,36 hyperlipidemia, 24,29,31,34,42 hyperuricemia, 36 pulmonary disease, 34 history of peptic ulcer, 31 hemoglobin level, 22 prothrombin, and activated partial thromboplastin time 22,25 were not found to be associated with PPB. Thrombocytopenia was associated with PPB in 1 study, 43 although 2 studies did not find differences in PPB rates.…”

“…36 Similarly, diabetes mellitus was not identified as a significant risk factor in any study. [13][14][15][16][17][18][20][21][22][23][24][28][29][30][31]33,34,36,42,44,45 Cardiopathy (ischemic heart disease in most studies), 10 were not identified as risk factors for PPB in most studies. Chronic kidney disease was not identified as a risk factor in some studies despite a trend to higher bleeding.…”

“…42 PPB rates were similar between genders in most studies, [13][14][15][16][17][18][20][21][22][23][25][26][27][28][29][30][31][32][33][34]36,39,[42][43][44] with only 1 study reporting an association male sex associated with PPB. 24 Arterial hypertension was not identified as a risk factor in most studies, [13][14][15]17,18,[20][21][22][23][24][28][29][30][31]33,42,43,45 although 2 studies reported significantly higher PPB rates in hypertensive patients. 16,36 However, the adjusted OR was .67 in the latter study.…”

“…54 Corticosteroid use was not identified as a risk factor for PPB. 16,24,43 Lesion characteristics. Tumor size and resected specimen size were evaluated as risk factors in several studies.…”

Continued use of low-dose aspirin may increase risk of bleeding after gastrointestinal endoscopic submucosal dissection: A meta-analysis

“…Some researchers have shown that patients are at higher risk of bleeding during or after ESD with continuous LDA use (9,26,27). Others have shown the opposite result, indicating that using the LDA continuously does not increase the hazard of bleeding (10,24).…”