Antithrombotic activity of Vitis labrusca extract on rat platelet aggregation

Kwon, Se‐Uk; Lee, Hoon-Yeon; Xin, Mingjie; Ji, Su-Jeong; Cho, Hyoung-Kwon; Kim, Dae-Sung; Kim, Dae‐Ki; Lee, Young-Mi

doi:10.1097/mbc.0000000000000394

Cited by 14 publications

(11 citation statements)

References 43 publications

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“…Platelet aggregation is essential for homeostasis. Antithrombotic agents have been developed to mitigate or prevent deregulated thrombosis [10]. Thrombin is the key effector enzyme of the coagulation system.…”

Section: Discussionmentioning

confidence: 99%

Antithrombotic Effect of Trigonella Foenum-Graceum on Collagen/ Epinephrine-Induced Thromboembolism in Mice

Saputri

Nityasa

2018

Int J App Pharm

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Objective: This study aimed to further investigate the antiplatelet and antithrombotic activities of Trigonella foenum-graceum (TFG) in vivo.Methods: Male mice were divided into two experimental groups (bleeding duration and survival rate). The study groups comprised vehicle controls(administered carboxymethyl cellulose [CMC]), negative controls (administered CMC), positive controls (administered aspirin), and experimentaltreatment groups (administered TFG extract at three doses). Bleeding duration was assessed by excising the tail vein. Survival rate was determinedby inducing thrombosis through intravenous collagen/epinephrine administration.Results: In mice treated with TFG extract for 7 days, bleeding duration was significantly increased compared with that in controls (p<0.05). Moreover,mice treated with TFG showed increased survival rates compared with negative controls.Conclusion: TFG extract showed antithrombotic activity in mice by significantly increasing bleeding duration and survival rate.

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Section: Discussionmentioning

confidence: 99%

Antithrombotic Effect of Trigonella Foenum-Graceum on Collagen/ Epinephrine-Induced Thromboembolism in Mice

Saputri

Nityasa

2018

Int J App Pharm

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“…Experiments were performed in rats were divided into the following groups: WKY ( n = 10), normal control group; SHR ( n = 12), negative control group; SHR + losartan, positive control group ( n = 12, 10 mg/kg/daily, AT 1 receptor blocker) and SHR + HP1 ( n = 12, 100 mg/kg/daily). Based on the initial study results, we conducted a 100 mg/kg/daily concentration [ 18 ]. HP1 was orally administered daily for 4 weeks.…”

Section: Methodsmentioning

confidence: 99%

Protective Effect of Vitis labrusca Leaves Extract on Cardiovascular Dysfunction through HMGB1-TLR4-NFκB Signaling in Spontaneously Hypertensive Rats

et al. 2020

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The Vitis labrusca is a grapevine that has antioxidant, neuroprotective, hepatoprotective, and anticarcinogenic activity. However, the effect of Vitis labrusca leaves on the cardiovascular system is yet to be ascertained. The present study was designed to investigate the effects of Vitis labrusca leaves extract (HP1) on cardiovascular remodeling in spontaneously hypertensive rats. Experiments were performed in rats and were randomly divided into the following groups: Wistar Kyoto rat (WKY), normal control group; spontaneously hypertensive rats (SHR), negative control group; SHR + Losa, positive control group (losartan, 10 mg/kg/daily, AT1 receptor blocker) and SHR + HP1 (100 mg/kg/daily). HP1 was orally administered daily for 4 weeks. The HP1 treatment significantly improved blood pressure, electrocardiographic parameters, and echocardiogram parameters compared to hypertensive rats. Additionally, the left ventricular (LV) remodeling and LV dysfunction were significantly improved in HP1-treated hypertensive rats. Furthermore, an increase in fibrotic area has been observed in hypertensive rats compared with WKY. However, administration of HP1 significantly attenuated cardiac fibrosis in hypertensive rats. Moreover, HP1 suppressed the expression of high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), receptor for advanced glycation end products (RAGE), and extracellular signal-regulated kinases (ERK1/2) induced by hypertensive rats, resulting in improved vascular remodeling. Therefore, these results suggest that HP1 can improve the cardiovascular remodeling in hypertensive rats, and the mechanisms may be related to the suppressive effect of HP1 on HMGB1-TLR4-NFκB signaling in the cardiovascular system. Thus, the protective role of the traditional herbal medicine HP1 may provide new insights into the development of therapeutic drugs on the development of hypertensive cardiovascular dysfunction.

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“…The cellular mechanism of the antiplatelet effect of V . labrusca may be related to the inhibition of the TXB 2 and serotonin secretion (Kwon et al ., ). Furthermore, fruits of V. vinifera are well known in the literature for their cardioprotective properties.…”

Section: Antiplatelet Properties Of Medicinal Plants: Bioactive Constmentioning

confidence: 97%

Medicinal Plants with Antiplatelet Activity

Haouari

Rosado

2016

Phytother. Res.

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Blood platelets play an essential role in the hemostasis and wound-healing processes. However, platelet hyperactivity is associated to the development and the complications of several cardiovascular diseases. In this sense, the search for potent and safer antiplatelet agents is of great interest. This article provides an overview of experimental studies performed on medicinal plants with antiplatelet activity available through literature with particular emphasis on the bioactive constituents, the parts used, and the various platelet signaling pathways modulated by medicinal plants. From this review, it was suggested that medicinal plants with antiplatelet activity mainly belong to the family of Asteraceae, Rutaceae, Fabaceae, Lamiaceae, Zygophyllaceae, Rhamnaceae, Liliaceae, and Zingiberaceae. The antiplatelet effect is attributed to the presence of bioactive compounds such as polyphenols, flavonoids, coumarins, terpenoids, and other substances which correct platelet abnormalities by interfering with different platelet signalization pathways including inhibition of the ADP pathway, suppression of TXA2 formation, reduction of intracellular Ca(2+) mobilization, and phosphoinositide breakdown, among others. The identification and/or structure modification of the plant constituents and the understanding of their action mechanisms will be helpful in the development of new antiplatelet agents based on medicinal plants which could contribute to the prevention of thromboembolic-related disorders by inhibiting platelet aggregation. Copyright © 2016 John Wiley & Sons, Ltd.

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Antithrombotic activity of Vitis labrusca extract on rat platelet aggregation

Cited by 14 publications

References 43 publications

Antithrombotic Effect of Trigonella Foenum-Graceum on Collagen/ Epinephrine-Induced Thromboembolism in Mice

Antithrombotic Effect of Trigonella Foenum-Graceum on Collagen/ Epinephrine-Induced Thromboembolism in Mice

Protective Effect of Vitis labrusca Leaves Extract on Cardiovascular Dysfunction through HMGB1-TLR4-NFκB Signaling in Spontaneously Hypertensive Rats

Medicinal Plants with Antiplatelet Activity

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