Antithrombotic activity of argan oil: An in vivo experimental study

Mekhfi, Hassane; Belmekki, Fatima; Ziyyat, Abderrahim; Legssyer, Abdelkhaleq; Bnouham, Mohamed; Aziz, Mohammed

doi:10.1016/j.nut.2011.11.032

Cited by 35 publications

(22 citation statements)

References 27 publications

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“…Furthermore, the phenolic, tocopherol, and saponin constituents of argan oil have been shown to provide powerful antioxidant effects [7]. Other properties that have been attributed to argan oil include antidiabetic [8,9] and antithrombotic activity [10]. Indeed, we performed a human trial of argan oil (from Algeria) and we showed that argan oil is able to positively modulate some surrogate markers of cardiovascular disease (CVD) [4].…”

Section: Introductionmentioning

confidence: 98%

Argan oil reduces, in rats, the high fat diet-induced metabolic effects of obesity

Sour¹,

Belarbi²,

Sari³

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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Section: Introductionmentioning

confidence: 98%

Argan oil reduces, in rats, the high fat diet-induced metabolic effects of obesity

Sour¹,

Belarbi²,

Sari³

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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“…When used as vessel substitutes in vivo, they need to be modified for high compliance, elongation, and strength. In addition, collagen has poor antithrombotic activity [29].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Study of a Novel Nanogold-Collagen Composite to Enhance the Mesenchymal Stem Cell Behavior for Vascular Regeneration

Hung

Chang

et al. 2014

PLoS ONE

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Novel nanocomposites based on type I collagen (Col) containing a small amount (17.4, 43.5, and 174 ppm) of gold nanoparticles (AuNPs, approximately 5 nm) were prepared in this study. The pure Col and Col-AuNP composites (Col-Au) were characterized by the UV-Vis spectroscopy (UV-Vis), surface-enhanced raman spectroscopy (SERS) and atomic force microscopy (AFM). The interaction between Col and AuNPs was confirmed by infrared (IR) spectra. The effect of AuNPs on the biocompatibility of Col, evaluated by the proliferation and reactive oxygen species (ROS) production of mesenchymal stem cells (MSCs) as well as the activation of monocytes and platelets, was investigated. Results showed that Col-Au had better biocompatibility than Col. Upon stimulation by vascular endothelial growth factor (VEGF) and stromal derived factor-1α (SDF-1α), MSCs expressed the highest levels of αvβ3 integrin/CXCR4, focal adhesion kinase (FAK), matrix metalloproteinase-2 (MMP-2), and Akt/endothelial nitric oxide synthase (eNOS) proteins when grown on the Col-Au (43.5 ppm) nanocomposite. Taken together, Col-Au nanocomposites may promote the proliferation and migration of MSCs and stimulate the endothelial cell differentiation. These results suggest that Col-Au may be used to construct tissue engineering scaffolds for vascular regeneration.

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“…Furthermore, when rats were fed for 4 weeks with 10 mL/kg/day of argan oil, the thrombin-induced aggregation of isolated platelets was significantly inhibited (36%), however, the tail bleeding time remained unchanged [27]. Recently, Mekhfi et al [28] have reported that argan oil has antithrombotic activity in rats, which could be related to its antiplatelet rather than its anticoagulant activity.…”

Section: Introductionmentioning

confidence: 99%

Argan oil prevents prothrombotic complications by lowering lipid levels and platelet aggregation, enhancing oxidative status in dyslipidemic patients from the area of Rabat (Morocco)

et al. 2013

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BackgroundIt is now established that patients with hyperlipidemia have a high risk of atherosclerosis and thrombotic complications, which are two important events responsible for the onset and progression of cardiovascular disease. In the context of managing dyslipidemia by means of dietary advice based on the consumption of argan oil, we wanted to investigate the effect of virgin argan oil on plasma lipids, and for the first time, on the platelet hyperactivation and oxidative status associated with dyslipidemia. This study concerns patients recruited in the area of Rabat in Morocco.Methods39 dyslipidemic (79% women) patients were recruited for our study in the area of Rabat in Morocco. They were randomly assigned to the two following groups: the argan group, in which the subjects consumed 25 mL/day of argan oil at breakfast for 3 weeks, and the control group in which argan oil was replaced by butter.ResultsAfter a 3-week consumption period, blood total cholesterol was significantly lower in the argan oil group, as was LDL cholesterol (23.8% and 25.6% lower, respectively). However, the HDL cholesterol level had increased by 26% at the end of the intervention period compared to baseline. Interestingly, in the argan oil group thrombin-induced platelet aggregation was lower, and oxidative status was enhanced as a result of lower platelet MDA and higher GPx activity, respectively.ConclusionsIn conclusion, our results, even if it is not representative of the Moroccan population, show that argan oil can prevent the prothrombotic complications associated with dyslipidemia, which are a major risk factor for cardiovascular disease.

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Antithrombotic activity of argan oil: An in vivo experimental study

Cited by 35 publications

References 27 publications

Argan oil reduces, in rats, the high fat diet-induced metabolic effects of obesity

Argan oil reduces, in rats, the high fat diet-induced metabolic effects of obesity

In Vitro Study of a Novel Nanogold-Collagen Composite to Enhance the Mesenchymal Stem Cell Behavior for Vascular Regeneration

Argan oil prevents prothrombotic complications by lowering lipid levels and platelet aggregation, enhancing oxidative status in dyslipidemic patients from the area of Rabat (Morocco)

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