Antithrombin III pretreatment reduces neutrophil recruitment into the lung and skeletal muscle tissues in the rat model of bilateral lower limb ischemia and reperfusion: a pilot study*

Duru, Seden; Koca, Uğur; Öztekin, Sermin; Olguner, Çimen; Kar, Anand; Çöker, Canan; Ulukuş, Çağnur; Taşcł, C; Elar, Zahi̇de

doi:10.1111/j.1399-6576.2005.00764.x

Cited by 36 publications

(31 citation statements)

References 30 publications

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“…Also reperfusion of ischemic areas facilitates local and systemic complications which may result in increased mortality and morbidity. Systemic infl ammatory response syndrome (SIRS) and multiple organ failure (MOF) are two important consequences of I/R injury (10,11). In these circumstances, amelioration of blood fl ow is essential in order to avoid cell death and deterioration of the ischemic damage by I/R injury (12).…”

Section: Discussionmentioning

confidence: 99%

Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury

Şıvgın¹,

Küçük²,

Çomu³

et al. 2017

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BACKGROUND AND AIM: Acute hind limb ischemia reperfusion (I/R) injury is a common consequence of abdominal aorta cross-clamping during aortic surgery. Erythrocyte deformability is affected by I/R process and may lead to increased tissue and organ injury. Lornoxicam and intravenous ibuprofen are becoming commonly used as non-steroidal anti-infl ammatory drugs (NSAID) for postoperative analgesia. In this study, we aimed to investigate the effects of lornoxicam (2 mg/kg iv) and intravenous ibuprofen (30 mg/kg iv) on erythrocyte deformability in I/R model in rats. MATERIALS AND METHODS: Four study groups, each containing 6 Wistar rats were created. Laparotomy was performed in all groups under general anesthesia with ketamine and xylazine. In all groups except sham group, ischemia and reperfusion were achieved by clamping and declamping the infrarenal abdominal aorta for 120 minutes. Rats in Group IR+L received intravenous infusion of lornoxicam (2 mg/kg) while rats in Group IR+I received intravenous infusion of ibubrofen (30 mg/kg) following 2 hours of ischemic period. At the end of reperfusion period, erythrocyte packs were prepared from heparinized blood samples. Erythrocyte suspensions with hematocrit at a concentration of 5% in a phosphate-buffered saline (PBS) were used in order to perform deformability measurements. The value of p < 0.05 was considered statistically signifi cant. RESULTS: Relative resistance has increased in ischemia reperfusion group when compared to control group (p < 0.0001). Lornoxicam or ibuprofen intravenous treatments did not change the erythrocyte deformability during ischemia reperfusion period in rats (p = 0.851, p = 0.690). CONCLUSION: Intravenous ibuprofen or lornoxicam administrations during ischemia reperfusion period in rats have no negative effect on erythrocyte deformability. The fi ndings of the study should be supported with more detailed and extensive clinical/experimental studies in the future (Fig. 1, Ref. 18). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury

Şıvgın¹,

Küçük²,

Çomu³

et al. 2017

BLL

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“…As reperfusion progresses, generally systemic infl ammatory response syndrome and multiple organ failure (kidney, respiratory and circulatory system, etc.) follow local edema and muscle necrosis (2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Effect of different doses of pregabalin on skeletal muscle ischaemia-reperfusion injury in rats

Öztürk¹,

Doğan²,

Kılıçarslan³

et al. 2017

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AIM/INTRODUCTION: Analgesic, anti-infl ammatory and anti-apoptotic effects of pregabalin have been shown previously. In this study, we investigated the protective effect of different doses of pregabalin on skeletal muscle IR injury in rats. MATERIALS AND METHODS: 24 rats were randomly divided into 4 groups (Control, Ischaemia-Reperfusion (IR), IR-Pregabalin 50 mg, IR-Pregabalin 200 mg). Following IR, serum Ischemia Modifi ed Albumin (IMA) and tissue Paraoxonase (PON) were studied and gastrocnemius muscle tissue was removed for histopathologic examination. RESULTS: Interstitial infl ammation was higher in the IR group than in the control and Pregabalin 200 mg groups (p = 0.037, p = 0.037, respectively). Congestion was higher in the IR group than in the control, Pregabalin 50 and 200 mg groups (p = 0.001, p = 0.004, p = 0.004, respectively). PON was lower in the IR group than in the Control, Pregabalin 50 and 200 mg groups (p = 0.001, p = 0.007, p = 0.015, respectively). IMA was higher in the IR group than in the Control, Pregabalin 50 and 200 mg groups (p < 0.0001, all). CONCLUSION: We think that administration of pregabalin, more prominent at 200 mg, can reverse the injury that occurs in the skeletal muscle of IR-induced rats. Pregabalin can be safely used for analgesia in cases of IR (Tab. 2, Fig. 9, Ref. 41). Text in PDF www.elis.sk.

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“…Local edema and muscle tissue necrosis are likely to be followed by systemic infl ammatory response syndrome and multiple organ failure (kidney, respiratory and circulatory system etc.) as reperfusion advances (1)(2)(3).…”

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confidence: 99%

Effect of iloprost on erythrocyte deformability in rat’s lower extremity undergoing an ischemia reperfusion injury

Arslan¹,

Dönmez²,

Erer³

et al. 2013

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Aim: Ischemia reperfusion injury (I/R) in lower extremity is a frequent and important clinical phenomenon. The protective effect of iloprost on local and distant organ injury due to I/R has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of iloprost on erythrocyte deformability in the infrarenal aorta of rats undergoing I/R. Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into the 3 groups; the randomized control group (group C; n=6), I/R group without iloprost (group I/R; n=6) and I/R group with iloprost -10 mcg.kg -1 , 30 min infusion (group I/R-I; n=6). Packs of erythrocytes were prepared from heparinized blood samples and deformability measurements were done. Results: The comparisons of the control and I/R-I groups revealed similar results (p=0.951). The values of the IR group were signifi cantly higher than those of the control and IR-I groups (p=0.006, p=0.011, respectively). Conclusion: In our study, we detected the unfavourable effects of I/R on erythrocyte deformability, which may lead to disturbance in blood fl ow and hence tissue perfusion in the infrarenal rat aorta. We also found that Iloprost had benefi cial effects by reversing the undesirable effects of I/R (Fig. 1, Ref. 15). Full Text in PDF www.elis.sk.

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Antithrombin III pretreatment reduces neutrophil recruitment into the lung and skeletal muscle tissues in the rat model of bilateral lower limb ischemia and reperfusion: a pilot study*

Abstract: Data from the present study provides some evidence that AT III pretreatment attenuates remote lung and local skeletal muscle tissue injury caused by lower limb I/R.

Cited by 36 publications

References 30 publications

Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury

Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury

Effect of different doses of pregabalin on skeletal muscle ischaemia-reperfusion injury in rats

Effect of iloprost on erythrocyte deformability in rat’s lower extremity undergoing an ischemia reperfusion injury

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