Antithrombin III and D-dimer levels as indicators of disease severity in patients with hyperlipidaemic or biliary acute pancreatitis

Yang, Ning; Hao, Jianyu; Zhang, Donglei

doi:10.1177/0300060516677929

Cited by 19 publications

(22 citation statements)

References 55 publications

(74 reference statements)

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“…Studies showing that the coagulation system is affected in AP have also shown that while thrombosis occurs with activation of the coagulant system, thrombosis breakdown increases with an increase in fibrinolytic activity [18, 19, 32]. In a study of 139 patients with pancreatitis, Maeda et al suggested that D-dimer, antithrombin III, fibrin/fibrinogen breakdown products, platelet number and TAT levels investigated at presentation were superior to CRP (CRP) in estimating the prognosis of the disease [7].…”

Section: Discussionmentioning

confidence: 99%

Higher Thrombin-Antithrombin III Complex Levels May Indicate Severe Acute Pancreatitis

Fidan

Erkut

Coşar

et al. 2018

Dig Dis

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Aim: Coagulation disorders may develop in association with severe acute pancreatitis (AP). Plasma thrombin-antithrombin III complex (TAT) levels are one of the principal markers of coagulation disorder. The purpose of this study was to evaluate TAT and other hemostatic parameters in patients with AP and to examine whether or not these parameters indicate the severity of AP. Method: Forty-six patients with AP (14 severe, 32 non-severe) and a 30-member healthy control group were recruited. The severity of AP was determined using the revised Atlanta classification. ELISA was used to measure patients’ plasma TAT levels. Results: The TAT levels of AP patients at presentation were higher than those of the control group (p = 0.005). The plasma TAT levels of patients with severe AP were also significantly higher than those of patients with non-severe AP (p = 0.05) and of the control group (p < 0.001). The general accuracy, sensitivity and specificity of TAT levels in predicting the severity of AP were 77.4, 77.8, and 77.3% respectively. Conclusion: The coagulation cascade was activated in the AP patients in our study, and this was shown to become more pronounced as severity of the disease increased. Plasma TAT levels at the time of presentation in patients with AP can be used as a marker for predicting the severity of the disease.

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Section: Discussionmentioning

confidence: 99%

Higher Thrombin-Antithrombin III Complex Levels May Indicate Severe Acute Pancreatitis

Fidan

Erkut

Coşar

et al. 2018

Dig Dis

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“…23 Anti-thrombin III with the help of heparin and heparan sulphate binds to and inactivates factor X and thrombin. 24 Protein C binds to thrombinthrombomodulin complex and is activated to inactivate factors VIII and V. Protein S is required as a cofactor in this protein C mediated inhibition. 25 Thrombomodulin which is a product of endothelial cells, acting independently, binds to and removes thrombin from circulation.…”

Section: Coagulationmentioning

confidence: 99%

Anti-thrombotic effect of Zingiber officinale (ginger) in sprague dawley rats

et al. 2019

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Background: The prevalence of thrombotic diseases is rising globally. Presently, stroke and ischemic heart disease account for 25% of all deaths. Use of anti-thrombotic drugs have proven effective in prevention of these ailments but might not be affordable especially in developing countries. They are also associated with undesirable side effects. This study sought to determine the anti-thrombotic effect of ginger since it is affordable, accessible and is widely used as a food enhancer and a medicinal herb.Methods: The current study employed an in-vivo experimental study design. Three groups Sprague dawley rats (N=5) were given different doses of methanolic extract of ginger for 30 days. Two other groups (N=5) which served as controls received 5% dimethyl sulfoxide and aspirin for the same duration. Measurement of bleeding time, platelet count, prothrombin time, activated partial thromboplastin time and thrombin time was done to assess the anti-thrombotic property.Results: There was a statistically significant difference in bleeding time (P=0.03) across the groups investigated. There was however no significant difference across the groups in platelet count, prothrombin time, activated partial thromboplastin time and thrombin time (P=˃0.05).Conclusion: This study demonstrates that methanolic extract of ginger possesses an anti-thrombotic property probably through inhibition of platelet function. Regular consumption of ginger may therefore confer protection against thrombotic diseases.

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“…Approximately 20% -50% of idiopathic severe acute pancreatitis is caused by biliary stones, with a maximum up to 60% -80% [6]. The clinical examination of biliary microlithiasis is difficult, and it is easy to be misdiagnosed as idiopathic pancreatitis [7].…”

Section: Biliarymentioning

confidence: 99%