Antisympathetic and hemodynamic property of a dual L/N-type Ca2+ channel blocker cilnidipine in rats

Takahara, Akira; Koganei, Hajime; Takeda, Tomoko; Iwata, Seiichi

doi:10.1016/s0014-2999(01)01521-7

Cited by 39 publications

(29 citation statements)

References 12 publications

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“…As shown in the results, antihypertensive doses of cilnidipine (3,5) lowered the diastolic blood pressure without affecting systolic blood pressure. This hemodynamic effect of cilnidipine may be explained by its pharmacological profile, in which cilnidipine more selectively inhibits L-type Ca 2+ channels located on the arterioles than those on the cardiac muscle (13).…”

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confidence: 53%

Cardiovascular Effects of an L/N-type Ca2+ Channel Blocker Cilnidipine Assessed in the Chronic Atrioventricular Conduction Block Dogs

et al. 2004

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Abstract. Cardiovascular effects of cilnidipine, a dual L / N-type Ca 2+ channel blocker, were evaluated in the chronic atrioventricular block dogs, of which systemic blood pressure and plasma catecholamine levels significantly increased in the pre-drug control. Administration of antihypertensive doses of cilnidipine (1 and 3 mg / kg, i.v.) significantly decreased the total peripheral vascular resistance, mean blood pressure, and atrial rate and increased the cardiac output. These results suggest that cilnidipine not only decreases the blood pressure, but also decreases the sinus automaticity in the in vivo hypertensive condition with increased adrenergic tones.

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confidence: 53%

Cardiovascular Effects of an L/N-type Ca2+ Channel Blocker Cilnidipine Assessed in the Chronic Atrioventricular Conduction Block Dogs

et al. 2004

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“…It was shown that cilnidipine suppresses sympathetic nerve activity of SHRs as well as normotensive rats. 27,28) It was reported that the efferent arterioles of normotensive WKY rats were regulated by sympathetic nerves in the same way as SHRs. 29) Thus, we assumed that cilnidipine has a vasodilatory effect on the efferent arterioles of SHRs and normotensive rats.…”

Section: Discussionmentioning

confidence: 99%

Vasodilatory Effect of Cilnidipine, an L-type and N-type Calcium Channel Blocker, on Rat Kidney Glomerular Arterioles

Konno

Kimura

2008

Int. Heart J.

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SUMMARYCilnidipine is a dihydropyridine calcium channel blocker that acts on both L-type and N-type calcium channels.The effects of cilnidipine given intravenously at doses of 2.5, 5.0, and 10 µg/kg were studied using an ex vivo hydronephrosis model in spontaneously hypertensive rats. The effects of nifedipine at a dose of 10 µg/kg were also studied using the same model as a reference.Cilnidipine caused dose-dependent blood pressure reduction and dilatation of the glomerular afferent arterioles; the arteriolar diameter after cilnidipine infusion at 2.5, 5.0, and 10 µg/kg was 101% ± 3%, 112% ± 4%, and 123% ± 6% relative to baseline, respectively. With cilnidipine, dilatation of the efferent arterioles was also observed; it was maximal after 5 to 10 minutes. Five minutes after administration of 2.5, 5.0, and 10 µg/kg of cilnidipine, the efferent arteriolar diameter was 103% ± 2%, 109% ± 4%, and 119% ± 4% of baseline, respectively. This efferent arteriolar dilating action of cilnidipine was abolished after pretreatment with ω-conotoxin, a selective N-type calcium channel blocker. A dose-dependent increase of glomerular blood flow volume was also observed after cilnidipine infusion. Nifedipine, an L-type calcium channel blocker, at a dose of 10 µg/kg reduced systolic blood pressure to a similar extent as cilnidipine at a dose of 10 µg/kg, but only dilated the afferent arterioles and had no significant effect on efferent arterioles.Cilnidipine dilated both the afferent and efferent glomerular arterioles. The efferent arteriolar dilating effect of cilnidipine may be attributed to its inhibition of the N-type calcium channel. (Int Heart J 2008; 49: 723-732)

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“…Cilnidipine and nilvadipine were initially dissolved in 50% hydrogenated castor oil (HCO-60; Nikko Chemicals, Tokyo, Japan)-ethanol solution, which were diluted with saline, as previously reported. 20) Pentobarbital sodium was dissolved in saline.…”

Section: Neuroprotective Effects Of a Dual L/n-typementioning

confidence: 99%

Neuroprotective Effects of a Dual L/N-type Ca2+ Channel Blocker Cilnidipine in the Rat Focal Brain Ischemia Model

Takahara

Konda

Enomoto

et al. 2004

Biological & Pharmaceutical Bulletin

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Antisympathetic and hemodynamic property of a dual L/N-type Ca2+ channel blocker cilnidipine in rats

Cited by 39 publications

References 12 publications

Cardiovascular Effects of an L/N-type Ca2+ Channel Blocker Cilnidipine Assessed in the Chronic Atrioventricular Conduction Block Dogs

Cardiovascular Effects of an L/N-type Ca2+ Channel Blocker Cilnidipine Assessed in the Chronic Atrioventricular Conduction Block Dogs

Vasodilatory Effect of Cilnidipine, an L-type and N-type Calcium Channel Blocker, on Rat Kidney Glomerular Arterioles

Neuroprotective Effects of a Dual L/N-type Ca2+ Channel Blocker Cilnidipine in the Rat Focal Brain Ischemia Model

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