Antistress Effects ofRosa rugosaThunb. on Total Sleep Deprivation–Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT₆Receptor Antagonist

Abstract

Our previous results suggest that the Rosa rugosa Thunb. (family Rosaceae) alleviates endurance exercise-induced stress by decreasing oxidative stress levels. This study aimed to screen and identify the physiological antistress effects of an extract of R. rugosa (RO) on sleep deprivation-induced anxiety-like behavior and cognitive tests (in vivo) and tested for hippocampal CORT and monoamine levels (ex vivo), corticosterone (CORT)-induced injury, N-methyl-d-aspartate (NMDA) receptor, and serotonin 6 (5-hydroxytryptamine 6, 5-HT6) receptor activities (in vitro) in search of active principles and underlying mechanisms of action. We confirmed the antistress effects of RO in a sleep-deprived stress model in rat and explored the underlying mechanisms of its action. In conclusion, an R. rugosa extract showed efficacy and potential for use as an antistress therapy to treat sleep deprivation through its antagonism of the 5-HT6 receptor and resulting inhibition of cAMP activity.

Lithium ameliorates sleep deprivation‐induced mania‐like behavior, hypothalamic‐pituitary‐adrenal (HPA) axis alterations, oxidative stress and elevations of cytokine concentrations in the brain and serum of mice

“…In agreement with the present findings, a recent study demonstrated an elevated corticosterone concentration in the serum of PSD rats when compared to controls . In addition, and corroborating the findings of the present study, several studies have demonstrated that the levels of corticosterone are increased after PSD . Suchecki and colleagues showed that PSD induced using different methods increased ACTH and corticosterone secretion.…”

“…39 In addition, and corroborating the findings of the present study, several studies have demonstrated that the levels of corticosterone are increased after PSD. [40][41][42][43] Suchecki and colleagues 40 showed that PSD induced using different methods increased ACTH and corticosterone secretion. Indeed, insomnia is associated with increases of ACTH and cortisol secretion, and activation of the HPA axis or administration of glucocorticoids can lead to arousal and sleeplessness.…”

Пряные И Ароматические Растения В Психиатрии И Неврологии: Научный Обзор. Часть Ii.

“…Розовой воде, экстракту и эфирному маслу лепестков розы традиционно приписывались в народной медицине многих стран успокаивающие, противотревожные, антистрессовые и лёгкие антидепрессивные свойства, а также способность улучшать память и когнитивные функции [Na J. et al, 2016].…”

“…В экспериментах на животных показано, что эфирное масло и экстракт из лепестков розы содержат вещества, ингибирующие активность 5-HT 6 серотониновых рецепторов, и что, благодаря этому, эфирное масло и экстракт лепестков розы улучшают когнитивные функции, память и внимание животных, оказывают антидепрессивное, антистрессовое и противотревожное действие в различных экспериментальных моделях тревоги и депрессии, таких, как модель выученной беспомощности или модель хронического социального стресса [Na J. et al, 2016].…”

Transcriptional responses of Rosa rugosa to salt stress and salt shock

“…Rosa rugosa Thumb., commonly known as rugosa rose or Japanese rose, is native to East Asia (Bruun, 2005). It is an important species for ornamental use in gardens, fragrance extraction, medicinal and food purposes, as well as a source of several valuable biological metabolites (Na et al, 2016;Olech;Nowak, 2012;Ren et al, 2018;Xie;Zhang, 2012;Zhang et al, 2019). Japanese rose is a salttolerant genotype capable of growing in naturally occurring sand dunes.…”