Antispermatozoal Antibody and Unexplained Infertility

Franklin, Robert R.; Dukes, Charles D.

doi:10.1097/00006254-196410000-00021

Cited by 27 publications

(35 citation statements)

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“…Franklin and Dukes (10) described a micro-agglutination technique which has been employed mainly for the analysis of sperm-agglutinating activity in sera from women. This micro-agglutination technique revealed sperm-agglutinating activity in 7-79 per cent of women with "unexplained" infertility (5, 10, 11, 12, 13, 16, 17, 22, 26).…”

Section: Introductionmentioning

confidence: 99%

A Simple and Sensitive Micro‐Method for Demonstration of Sperm‐Agglutinating Activity in Serum from Infertile Men and Women

Friberg

1974

Acta Obstet Gynecol Scand

287

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Section: Introductionmentioning

confidence: 99%

A Simple and Sensitive Micro‐Method for Demonstration of Sperm‐Agglutinating Activity in Serum from Infertile Men and Women

Friberg

1974

Acta Obstet Gynecol Scand

287

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“…Tube slide agglutination test (Franklin-Dukes technique) 4.5 mill/ml 1:1.1 tFranklin and Dukes, 1964 ) Tests employing spermatozoa separated from seminal plasma by centrifugation (without subsequent washing) Cytotoxicity test (Hamerlynck and Rumke, 1968) Microtechnique for simultaneous detection of immobilization and cytotoxicity (Husted and Hjort, 1975) Tests employing washed spermatozoa Immobilization tests (Isojima et ai, 1974;Isojima and Koyama. 1976) method has been used extensively in the investigation of infertile males.…”

Section: Gelatin Agglutinationmentioning

confidence: 99%

Immunology and Reproduction

Mettler¹

1980

Gynecol Obstet Invest

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This review on sterility immunology deals exclusively with immunological mechanisms hindering gamete junction. It does not elaborate the different immunological aspects of infertility after gamete junction. Thus spermatozoal seminal plasma and ovum antigens producing auto- or isoimmunization as immunological mechanisms hindering gamete junction in vitro and in vivo are discussed. Local immune response is compared to general immune response discerning between antibody production and cellular immunity. The commonly used diagnostic tools, the application of these test methods, the clinical therapeutical significance and the scientific objectives for further research in the area of reproductive immunology are outlined. It becomes evident that research in immunology of reproduction is performed with two targets: (1) diagnosis and treatment of the so-called ‘immunological sterility’, and (2) development of an immunological contraceptive.

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“…Die Behandlung mit kleineren oder grSBeren Dosen yon Kortikosteroiden war nicht yon Erfolg gekrSnt. Verschiedene Autoren berichteten fiber die Wirksamkeit des coitus condomatosus [1,7]. Hohe AntikSrpertiter wurden in der Folge gesenkt und in manchen F~illen erfolgten Schwangerschaften.…”

Section: Behandlung Des Zervixfaktorsunclassified