Antispermatogenic activity of 1-p-chlorobenzyl-1H-indazol-3-carboxylic acid () in rats

Burberi, S; Catanese, B; Cioli,; Ps, Barcellona; Silvestrini, Bruno

doi:10.1016/0014-4800(75)90027-1

Cited by 21 publications

(1 citation statement)

References 11 publications

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“…The sensitivity of the method was 1 jigml-' serum or ascites. The identity of diclondazolic acid was checked by thin layer chromatography, using a method applied to AF 1312/TS (Burberi et al, 1975).…”

Section: In Vivo Testsmentioning

confidence: 99%

Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems

Silvestrini¹,

Hahn²,

Cioli³

et al. 1983

Br J Cancer

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Summary Lonidamine or 1-[(2, 4-dichlorophenyl) methyl]-lH-indazole-3-carboxylic acid, studied in a battery of in vitro and in vivo tests currently used for the screening of anti-tumour agents affecting cell division, has been shown to have a narrow spectrum of anti-tumour activity. The significance of this finding is discussed in the light of previous investigations suggesting that lonidamine affects mitochondrial function and not cell replication. Hyperthermia has been shown to sensitize tumour cells to lonidamine. This observation indicates that in combination with hyperthermia lonidamine has some potential for the treatment of cancer; moreover, it suggests that hyperthermia might reproduce a metabolic condition occurring in some stages of the disease. The blood levels corresponding to the anti-tumour action of lonidamine in animals are in the range of those detected in patients treated with the drug.

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Section: In Vivo Testsmentioning

confidence: 99%

Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems

Silvestrini¹,

Hahn²,

Cioli³

et al. 1983

Br J Cancer

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The Differential Effects of the Indazole‐Carboxylic Acid Derivative, Tolnidamine, on Sertoli Cell Protein Secretion

Rossi

Cheng

Gunsalus

et al. 1989

Journal of Andrology

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The indazole‐carboxylic acid derivative tolnidamine (TOL) has marked antispermatogenic activity in rats. Previous morphological and biochemical studies indicate that Sertoli cells are one of the targets of this compound. The aim of this study was to assess the effect of TOL on the in vitro secretory functions of primary Sertoli cell‐enriched cultures prepared from rats of different ages by monitoring the changes of three known Sertoli cell proteins, androgen binding protein (rABP), transferrin (rTF), and testibumin (rTB). The addition of TOL at the beginning of the culture period reduced the plating efficiency of Sertoli cells; however, TOL did not induce a significant change in cell number if it was added 24 h after plating of the cells. Sertoli cell‐enriched cultures prepared from testes of 10‐day‐old rats were highly sensitive to TOL as evidenced by a marked inhibition in secretions of rABP, rTB, and rTF in all experiments. In cultures prepared from 15‐ and 20‐day‐old rats, TOL had no apparent effect on rABP secretion, but reduced rTF and increased rTB secretion. Thus, TOL has a differential effect on the secretion of individual proteins in Sertoli cells cultured from rats between 10 and 20 days of age. This phenomenon is presumably a consequence of the progressive maturation of Sertoli cells in the seminiferous epithelium.

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Contraception — retrospect and prospect

Harper¹

1977

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Rechersches Pharmaceutiques

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Antispermatogenic activity of 1-p-chlorobenzyl-1H-indazol-3-carboxylic acid () in rats

Cited by 21 publications

References 11 publications

Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems

Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems

The Differential Effects of the Indazole‐Carboxylic Acid Derivative, Tolnidamine, on Sertoli Cell Protein Secretion

Contraception — retrospect and prospect

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