Antispasmodics. II. Tertiary β-Amino Alcohols

Synthesis of Diastereoisomeric 4-Dimethylamino-3-phenyl-2-butanols and Related Esters for Antimicrobial Evaluation

“…Many other spectrophotometric and TLC methods subsequently were proposed for the determination of sulfonamides in biological fluids (4)(5)(6)(7)(8)(9)(10)(11)(12). GLC of the sulfa drugs also was attempted (13-15).…”

Use of 3-Azabicyclo[3.2.2.]nonane in the Mannich Reaction III.

“…Of the tertiary amino carbinols which have been reported in the literature, many have shown greater antispasmodic activity than the ketones from which they were derived (9)(10)(11). Some are suitable for the treatment of Parkinsonism and also for the treatment of similar tremors brought about as side-effects b y certain tranquilizing drugs (12,13).…”

5-Chloro-2-thienyl-β-dialkylaminoethyl Ketones and Related Compou47

“…Denton and his co-workers (2) in a series of papers described the antispasmodic activity of compounds of this type. Specifically, they observed that 2-(fl-piperidinopropionyl) -thiophene hydrochloride possesses antispasmodic activity equal to that of 8-diethylaminoethyl diphenylacetate hydrochloride (Trasentinem) and greater than that of papaverine.…”