Antispasmodics for labour

Rohwer, Anke; Khondowe, Oswell; Young, Taryn

doi:10.1002/14651858.cd009243.pub3

Cited by 25 publications

(28 citation statements)

References 35 publications

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“…A Cochrane review reported that intrapartum antispasmodics significantly accelerate the first stage of labor by increasing the cervical dilatation rate without compromising the durations of the second and third stages of labor or the rate of normal vertex deliveries . The current study demonstrated that metoclopramide significantly reduced the duration of the first stage of labor and increased the cervical dilatation rate.…”

Section: Discussionsupporting

confidence: 52%

Use of an antiemetic to shorten the length of labor in nulliparous women, exploring a potential role of an old drug: A randomized controlled trial

Ellaithy

Rasheed²,

Shafik³

et al. 2019

Intl J Gynecology & Obste

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Objective To assess whether metoclopramide is effective in shortening the duration of the first stage of labor in primiparous women. Methods The present randomized, double‐blind, placebo‐controlled trial was conducted at King Faisal Hospital, Saudi Arabia (between July 30, 2013, and September 1, 2016), and sequentially recruited young nulliparous women admitted in spontaneous active labor with or without ruptured membranes. Eligible participants were randomly assigned to receive a slow intravenous injection of either metoclopramide or placebo and consistently managed according to the local institutional intrapartum protocol and received identical monitoring and supportive care. The primary outcome was the cervical dilatation rate. Results Fifty‐nine women were included in the metoclopramide group and 52 in the placebo group. The first stage of labor was significantly shorter in the metoclopramide group (203 minutes vs 230 minutes in the placebo group, P=0.019), with a faster cervical dilatation rate (2.4 ± 0.4 cm/h vs 1.9 ± 0.5 cm/h in the placebo group, P<0.001) and shorter interval from treatment administration until full cervical dilatation. There was a significantly higher probability of faster delivery among women who were treated with metoclopramide (log‐rank test, χ2=5.997, P=0.014). Conclusion Metoclopramide safely reduced the duration of the first stage of labor and was not associated with major maternal or neonatal adverse outcomes. ClinicalTrials.gov NCT01937234

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Section: Discussionsupporting

confidence: 52%

Use of an antiemetic to shorten the length of labor in nulliparous women, exploring a potential role of an old drug: A randomized controlled trial

Ellaithy

Rasheed²,

Shafik³

et al. 2019

Intl J Gynecology & Obste

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“…Modern times, "Active Management" trends towards curtailing the total duration of labour compatible with the safety of the mother and foetus. 1 Drotaverine, an isoquinoline derivative, inhibits specifically phosphodiesterase IV (PDE IV) which in turn increases the intracellular concentration of cAMP and cGMP and causes smooth muscle relaxation. Inj.…”

Section: Introductionmentioning

confidence: 99%

A comparative study on the efficacy of drotaverine and valethamate on cervical dilatation during labour

Sinhasane

2017

Int J Reprod Contracept Obstet Gynecol

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Background: The most common cause of prolonged first stage of labour is cervical spasm leading to cervical dystocia. Many times it is observed that inspite of good uterine contractions; cervix fails to dilate or dilates very slowly. This is functional cervical dystocia.Methods: On admission detailed history was taken, complete general physical examination was made. Careful obstetric examination confirmed the lie, presentation, position of the foetus and FHP. Vaginal examination was made and the state of cervix (Dilatation, consistency and effacement) station of the vertex and type and adequacy of the pelvis was noted.Results: A slight increase in the cervical tear is noted in the multrigravida in Group II. The incidence of PPH was double that of Group III. This was observed specifically when the drug was given after 5cms of dilatation of cervix.Conclusions: The maternal adverse effects were more with valethamate. Though there was transient fetal tachycardia with valethamate, the fetal outcome remained the same in all the groups.

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“…In a Cochrane review known as "antispasmodic for labor" (2013), it was stated that there was no statistical significant relationship between musculotropic drugs with tachycardia, fetal distress, fetal tachycardia and bradycardia, admission to NICU, mouth dryness, headache, nausea, vomiting, dizziness, giddiness, and meconium-stained liquor, but flushing of face and postpartum hemorrhage were significant [3]. Promethazine is an antihistamine and is derived from phenothiazine (H1 receptor inhibitor) and can have a similar effect as anticholinergic and antimuscarinic drugs on inhibiting acetylcholine receptor.…”

Section: This Article Is Part Of the Topical Collection On Medicinementioning

confidence: 99%

“…In the delivery room (especially in Zanjan-Iran hospitals), promethazine is used to reduce nausea [27], to sedate [28], and to relieve pain [29,30]. In a Cochrane systematic review titled as "antispasmodic for labor," 21 articles were analyzed (with 3286 participants) and no side effects and neonatal risks of this drug were mentioned [3].…”

Section: This Article Is Part Of the Topical Collection On Medicinementioning

confidence: 99%

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The Effect of Intramuscular Hyoscine and Hyoscine-Promethazine on the Duration of Labor in Nulliparous Pregnant Women (Triple-Blind Randomized Controlled Trial)

shafaie

Shahmohammadi

Jafarabadi

et al. 2018

SN Compr. Clin. Med.

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Childbirth consists of a three-stage period beginning with uterine, contractions, and ending in the expulsion of the placenta. The aim of this study was the effect of intramuscular hyoscine and hyoscine-promethazine on the duration of labor in nulliparous pregnant women. This study was a triple-blind clinical trial on 213 nulliparous pregnant women who had referred to Amiralmomenin hospital in Zanjan, Iran. Selection of samples was random and done with using 3, 6(1:1:1) of blocking ratio. This study had three groups. The first group received 20 mg hyoscine (group A), the second group 3 cc sterile water (group B), and the third group 20 mg hyoscine and 25 mg promethazine (group C). Data collection tools included a demographic questionnaire, checklist of data, and partograph chart. The mean of the first stage of labor in hyoscine group was 88.95 ± 51.07 min, hyoscine-promethazine 100.05 ± 65.88 min, and control group 170.37 ± 106.87 min. There was significant correlation between A and C and B and C groups (P < 0.001). The mean of the second stage in group A was 46.37 ± 44.60, group B 32.25 ± 17.74, and control group 55.05 ± 44.44 min and a significant relationship was between B and C groups (P = 0.03). The results showed that hyoscine and hyoscine-promethazine can be used to reduce the duration of labor.

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Antispasmodics for labour

Abstract: Analysis 2.3. Comparison 2 Antispasmodics versus control: studies including caesarean section versus studies excluding C/S in analysis, Outcome 3 Duration of third stage of labour (min).

Cited by 25 publications

References 35 publications

Use of an antiemetic to shorten the length of labor in nulliparous women, exploring a potential role of an old drug: A randomized controlled trial

Use of an antiemetic to shorten the length of labor in nulliparous women, exploring a potential role of an old drug: A randomized controlled trial

A comparative study on the efficacy of drotaverine and valethamate on cervical dilatation during labour

The Effect of Intramuscular Hyoscine and Hyoscine-Promethazine on the Duration of Labor in Nulliparous Pregnant Women (Triple-Blind Randomized Controlled Trial)

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