Antispasmodics for labour

Rohwer, Anke; Khondowe, Oswell; Young, Taryn

doi:10.1002/14651858.cd009243.pub2

Cited by 9 publications

(8 citation statements)

References 31 publications

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“…A Cochrane review reported that intrapartum antispasmodics significantly accelerate the first stage of labor by increasing the cervical dilatation rate without compromising the durations of the second and third stages of labor or the rate of normal vertex deliveries . The current study demonstrated that metoclopramide significantly reduced the duration of the first stage of labor and increased the cervical dilatation rate.…”

Section: Discussionsupporting

confidence: 52%

Use of an antiemetic to shorten the length of labor in nulliparous women, exploring a potential role of an old drug: A randomized controlled trial

Ellaithy

Rasheed²,

Shafik³

et al. 2019

Intl J Gynecology & Obste

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Objective To assess whether metoclopramide is effective in shortening the duration of the first stage of labor in primiparous women. Methods The present randomized, double‐blind, placebo‐controlled trial was conducted at King Faisal Hospital, Saudi Arabia (between July 30, 2013, and September 1, 2016), and sequentially recruited young nulliparous women admitted in spontaneous active labor with or without ruptured membranes. Eligible participants were randomly assigned to receive a slow intravenous injection of either metoclopramide or placebo and consistently managed according to the local institutional intrapartum protocol and received identical monitoring and supportive care. The primary outcome was the cervical dilatation rate. Results Fifty‐nine women were included in the metoclopramide group and 52 in the placebo group. The first stage of labor was significantly shorter in the metoclopramide group (203 minutes vs 230 minutes in the placebo group, P=0.019), with a faster cervical dilatation rate (2.4 ± 0.4 cm/h vs 1.9 ± 0.5 cm/h in the placebo group, P<0.001) and shorter interval from treatment administration until full cervical dilatation. There was a significantly higher probability of faster delivery among women who were treated with metoclopramide (log‐rank test, χ2=5.997, P=0.014). Conclusion Metoclopramide safely reduced the duration of the first stage of labor and was not associated with major maternal or neonatal adverse outcomes. ClinicalTrials.gov NCT01937234

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Section: Discussionsupporting

confidence: 52%

Use of an antiemetic to shorten the length of labor in nulliparous women, exploring a potential role of an old drug: A randomized controlled trial

Ellaithy

Rasheed²,

Shafik³

et al. 2019

Intl J Gynecology & Obste

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“…Sharma et al, Nagaria et al, Dahal et al, Patil et al, Mandal and Molla in their studies also reported significantly higher incidence of tachycardia in the valethamate group (20%, 22%, 21%, 28%, 9% respectively). 12,13,18,20,23 All the side effects were minor, did not need specific treatment and subsided on their own in this study as also reported by Sharma et al, Nagaria et al, Dahal et al, Patil et al, Mandal and Molla. 12,13,18,20,23 In the present study there was no incidence of adverse Apgar score in either group related to drug given.…”

Section: Discussionsupporting

confidence: 83%

“…The drug delivery interval was slightly better with valethamate bromide in the present study as compared to when the drugs were given in the studies of 12,13,19,[21][22][23] The sample size in the studies of Madhu et al and Dahal et al were small, but drotaverine was found to have a shorter drug delivery interval than the other group. 19,20 As seen in the present study, 96.7% subjects in Group A and 94% in Group B had normal vaginal delivery. LSCS was done for 5 subjects in Group A and 7 subjects in Group B and 2 subjects had forceps delivery in Group B.…”

Section: Discussionsupporting

confidence: 76%

Drotaverine hydrochloride versus valethamate bromide for cervical dilatation in labour: a comparative study

Deepshikha

Soni

Gupta

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: Labor is the most perilous journey a woman has to undertake. Painless and short labor is desired by every woman and is a constant aim for obstetrician. Objective of this study was to compare the efficacy of drotaverine hydrochloride with valethamate bromide for cervical dilatation in labor in primigravida.Methods: The present study was conducted in the department of obstetrics and gynecology, S. P. Medical College and Associated Group of Hospitals, Bikaner, Rajasthan from 1st August 2018 to 31st July 2019 over a period of 1 year. Total of 300 patients were included in the study with 150 patients in each of the two groups. In this study the effects of Drotaverine hydrochloride (Group A) and Valethamate bromide (Group B) on cervical dilatation were compared.Results: In our study, the mean drug delivery interval was 101.58±78.06 mins in Group A and 134.24±94.12 mins in Group B. The mean number of doses of drug required was 1.27±0.55 in Group A and 4.17±1.62 in Group B. The difference was statistically highly significant (p <0.001).Conclusions: Drotaverine hydrochloride is found to be better than valethamate bromide in shortening the duration of active phase of labor in primigravidae. Drotaverine was found to be a better drug, hence, can be used to reduce the agony of the laboring woman without any significant side effects on the mother or the fetus.

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“…A recent Cochrane review [7] found low quality evidence that antispasmodic drugs reduce the duration of first stage of labor and increase the cervical dilatation rate; very low quality evidence that they reduce the total duration of labor; and insufficient evidence to make any conclusion about the safety of these medications. It was therefore advised that large, well‐designed, randomized controlled trials are needed to evaluate the role of antispasmodic drugs in the management of labor [7].…”

Section: Introductionmentioning

confidence: 99%