Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: Role of the active constituents of Glycyrrhizae radix

Lee, Keiko K.; Omiya, Yuji; Yuzurihara, Mitsutoshi; Kase, Yoshio; Kobayashi, Hiroyuki

doi:10.1016/j.jep.2012.11.005

Cited by 54 publications

(56 citation statements)

References 28 publications

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“…In the acute ethanol exposure experiment, ethanol treatment induced a slight increase of Nrf2, HO-1 and GCLC expression, whereas GCM/ethanol treatment led to a further increase of Nrf2 and its two transcriptional targets in liver tissues ( Fig 3C). Taken together, these results indicate that treatment with GCM resulted in up-regulation of Nrf2 downstream targets HO-1 and GCLC in both chronic and acute alcohol exposure models, suggesting that Nrf2 was ranscriptionally 12 activated by GCM exposure in vivo.…”

Section: Nrf2 Activation By Gcm In Vivomentioning

confidence: 57%

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Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy

Song

Yin

Huo

et al. 2015

Free Radical Biology and Medicine

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Section: Nrf2 Activation By Gcm In Vivomentioning

confidence: 57%

“…anti-spasmodic effect (12). We hypothesized that GCM could be one active component of licorice that contributed to its liver protection activity.…”

Section: Introductionmentioning

confidence: 99%

Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy

Song

Yin

Huo

et al. 2015

Free Radical Biology and Medicine

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“…It has been reported that shakuyaku-kanzo-to is safe 11 and rapidly effective 12 in treating muscle cramps and spasm of smooth and skeletal muscle. 13 The likely explanation for the efficacy of shakuyaku-kanzo-to in these conditions is a decrease in abnormal muscle tonus. Improvement in EPS may be mediated through acetylcholine receptors.…”

Section: Discussionmentioning

confidence: 99%

Effects of Shakuyaku-Kanzo-to on Extrapyramidal Symptoms During Antipsychotic Treatment

Ota¹,

Miura²,

Kanno-Nozaki³

et al. 2015

Journal of Clinical Psychopharmacology

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Extrapyramidal symptoms (EPS) are common adverse effects of antipsychotic treatment. This study examined the effects of the traditional Japanese herbal medicine (kampo) shakuyaku-kanzo-to on EPS during antipsychotic treatment. Twenty-two Japanese patients with psychiatric disorders who had developed EPS during antipsychotic treatment were randomly allocated to receive either shakuyaku-kanzo-to (7.5 g/d) or biperiden (3 mg/d) for 2 weeks. Extrapyramidal symptoms were evaluated using the Drug-Induced Extrapyramidal Symptom Scale (DIEPSS) and the Barnes Akathisia Rating Scale. Plasma levels of the monoamine metabolite homovanillic acid and serum prolactin levels were measured to investigate the mechanisms of action of shakuyaku-kanzo-to. Twenty of the 22 patients completed the study (10 patients in the shakuyaku-kanzo-to group and 10 patients in the biperiden group). There was a time effect on the Drug-Induced Extrapyramidal Symptom Scale total score (P < 0.01), suggesting that both shakuyaku-kanzo-to and biperiden decreased EPS. Notably, there was a time × drug interaction in dystonia, suggesting that shakuyaku-kanzo-to had a greater effect on dystonia compared with biperiden. No significant changes were observed in plasma homovanillic acid or serum prolactin levels after 2 weeks of treatment in either group. The effects of shakuyaku-kanzo-to on abnormal muscle tonus and dopamine D2 receptors may have contributed to improve EPS. These results suggest that shakuyaku-kanzo-to may be useful in decreasing EPS, especially dystonia, in patients undergoing treatment with antipsychotic agents.

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“…Glycycoumarin (GCM) is a major coumarin in licorice with favorable pharmacologic property in vivo 8. Previous studies have shown that GCM possesses antiviral910, anti-inflammatory11 and anti-spasmodic effect12. Our recent study has demonstrated that GCM is able to protect against alcohol-induced hepatotoxicity in both chronic and acute alcoholic liver injury animal models13.…”

mentioning

confidence: 99%

Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway

Zhang

Yin

Song

et al. 2016

Sci Rep

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Herbal medicine as an alternative approach in the treatment of disease has drawn growing attention. Identification of the active ingredient is needed for effective utilization of the herbal medicine. Licorice is a popular herbal plant that is widely used to treat various diseases including liver diseases. Glycycoumarin (GCM) is a representative of courmarin compounds isolated from licorice. In the present study, the protective effect of GCM on hepatocyte lipoapoptosis has been evaluated using both cell culture model of palmitate-induced lipoapoptosis and animal model of non-alcoholic steatohepatitis (NASH). The results demonstrated for the first time that GCM was highly effective in suppressing hepatocyte lipoapoptosis in both in vitro and in vivo. Mechanistically, GCM was able to re-activate the impaired autophagy by lipid metabolic disorders. In line with the activation of autophagy, ER stress-mediated JNK and mitochondrial apoptotic pathway activation was inhibited by GCM both in vitro and in vivo. In addition, inactivation of GSK-3 might also contribute to the protective effect of GCM on hepatocyte lipoapoptosis. Our findings supported GCM as a novel active component of licorice against non-alcoholic fatty liver disease (NAFLD).

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Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: Role of the active constituents of Glycyrrhizae radix

Cited by 54 publications

References 28 publications

Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy

Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy

Effects of Shakuyaku-Kanzo-to on Extrapyramidal Symptoms During Antipsychotic Treatment

Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway

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