Antispasmodic Effect of Essential Oils and Their Constituents: A Review

Hegheş, Simona Codruţa; Voștinaru, Oliviu; Rus, Lucia; Mogoşan, Cristina; Iuga, Cristina; Filip, Lorena

doi:10.3390/molecules24091675

Cited by 53 publications

(37 citation statements)

References 171 publications

(75 reference statements)

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“…Potassium plays an important role in muscle tonus. The activity of voltage-dependent potassium channels inactivates calcium channels resulting in relaxation of smooth muscles [21,22].…”

Section: Fig 4 Mean Scores Of Crying and Fussing Duration From Basementioning

confidence: 99%

“…The exact cause for the incidence of colic is not known. However, the essential oils can easily cross the cell membranes and influence on ion channels to intracellular enzymes [22]. It can be stated that, in case of using essential oil, they can bond with special receptors of calcium channels and exert their antispasmodic effect, or it may be hypothesized that, the use of topical form of essential oils would require less time for herbal remedies to reach a constant level to influence on intestinal microflora.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Matricaria chamomilla L. in Infantile Colic: A Double Blind, Placebo Controlled Randomized Trial

Sorme

Tabarra

Alimadady

et al. 2020

JPRI

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Objective: Infantile colic is one of the most common problems in neonatal and early infancy, the prevalence of which has been reported as 10-20%. The present clinical trial was conducted to investigate whether topical use of chamomile oil reduces crying and fussing in breastfed colicky infants. Methods: A total of 102 breastfed colicky infants were divided into two groups to receive topical chamomile or placebo oil 6 times a day for 7 days. Both groups also received 5 mg of Simethicone syrup 4 times a day. Parents reported on crying and fussing duration, exertion times and side effects using a questionnaire. Results: 90 babies could complete the trial including 47 patients in chamomile group and 43 patients in the placebo group. Babies in both groups were the same in terms of gestational age, birth weight, birth order, gender, delivery type, crying and fussing on the day before the treatment. At the end of the study, crying and fussing was found to be lower in chamomile group than the placebo group (p <0.001). Also, 39 and 27 patients responded to the treatment in chamomile and placebo groups respectively. The effect of chamomile oil on crying (p<0.01) and fussing (p< 0.001) was significant. No serious adverse event was reported. Conclusion: Results revealed that chamomile oil reduced symptoms in breastfed colicky infants compared to the infants in the placebo group. This suggests that topical use of chamomile oil may be effective in the treatment of colic.

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“…Potassium plays an important role in muscle tonus. The activity of voltage-dependent potassium channels inactivates calcium channels resulting in relaxation of smooth muscles [21,22].…”

Section: Fig 4 Mean Scores Of Crying and Fussing Duration From Basementioning

confidence: 99%

mentioning

confidence: 99%

Efficacy of Matricaria chamomilla L. in Infantile Colic: A Double Blind, Placebo Controlled Randomized Trial

Sorme

Tabarra

Alimadady

et al. 2020

JPRI

View full text Add to dashboard Cite

show abstract

“…Although Geraniol is composed of a combination of plants, its health benefits are of similar to those observed by Citronellol oil [5][6][7]. Accumulating evidence suggests that both of these oils have a calming effect and reduce anxiety, stress, and depression, yet their neuroprotective properties remain obscure [3,6]. Hence, the current study evaluates these EOs for neuroprotective qualities to the activity of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, AMPARs.…”

Section: Introductionmentioning

confidence: 97%

“…Essential oils (EOs) are usually extracted from plants and are used for aromatherapy, which is an alternative medicine that demonstrates the healing effect to the aromatic compounds presented in the oil [1,2]. Although its therapeutic potential remains controversial, the usage of essential oil has been increasingly popular in the general population [3]. Many EOs are currently being presented to showcase a wide range of benefits; two important EOs are the Citronellol and Geraniol oils.…”

Section: Introductionmentioning

confidence: 99%

Effect of Geraniol and Citronellol Essential Oils on the Biophysical Gating Properties of AMPA Receptors

2019

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Essential oils have been advertised endlessly to be very beneficial for the health of humans, and an extensive amount of research examines the validity of such claims. In contribution, the current study evaluates the neuroprotective properties of Citronellol and Geraniol essential oils (EOs). In relationship to the biophysical gating properties of different the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunits, the EOs were administered to HEK293 (Human embryonic kidney 293) cells and examined for any inhibition and effect on desensitization or deactivation rates, using whole-cell patch-clamp electrophysiology. Our results demonstrated the highest levels of inhibition from Citronellol oil by four-fold on all AMPARs subunits. Likewise, Geraniol oil had a similar inhibiting impact on the receptors, and both oils decreased the desensitization and deactivation rates of the inhibited receptors. Thus, the examined EOs of this study portray neuroprotective qualities by targeting AMPARs activation and reducing desensitization and deactivation rates. Finally, the results of the current study entail a better understanding of AMPARs, provides a natural template for future drug synthesis to treat neurological diseases associated with excessive AMPAR activation, and offers a possible mechanism by which these essential oils deploy their ‘calming’ effect.

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“…Some essential oils like peppermint oil are already used in clinical settings for the treatment of functional dyspepsia or irritable bowel syndrome. Numerous in vitro and in vivo experiments have proved significant antioxidant, antimicrobial, anxiolytic, spasmolytic or anti-inflammatory effects for several essential oils, which could be also translated in human medicine [4,5].…”

Section: Introductionmentioning

confidence: 99%

Safety Profile of Essential Oils

Voștinaru¹,

Hegheş²,

Filip³

2020

Essential Oils - Bioactive Compounds, New Perspectives and Applications

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Essential oils are complex mixtures of terpenes and phenylpropanoid compounds, present in multiple species of aromatic plants. They are extensively used in food and cosmetic industries in order to give flavor to food and drinks or as natural fragrances. Moreover, several compounds present in essential oils are important for the pharmaceutical industry due to their antioxidant, antimicrobial, anxiolytic or spasmolytic effects. Although many essential oils are generally recognized as safe, a series of adverse reactions have been reported after their use either by internal or external routes. The aim of this chapter is to increase the awareness of healthcare professionals concerning possible safety issues of essential oils. Common adverse effects of essential oils like sensitization and dermatitis but also more severe phenomena like neurotoxicity will be presented in detail, concerning their epidemiology, mechanism and clinical significance. A thorough understanding of the safety profile of essential oils is necessary for healthcare and food industry professionals in order to maximize their beneficial effects while minimizing the risk for the users.

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Antispasmodic Effect of Essential Oils and Their Constituents: A Review

Cited by 53 publications

References 171 publications

Efficacy of Matricaria chamomilla L. in Infantile Colic: A Double Blind, Placebo Controlled Randomized Trial

Efficacy of Matricaria chamomilla L. in Infantile Colic: A Double Blind, Placebo Controlled Randomized Trial

Effect of Geraniol and Citronellol Essential Oils on the Biophysical Gating Properties of AMPA Receptors

Safety Profile of Essential Oils

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