Antispasmodic, antidepressant and anxiolytic effects of extracts from Schinus lentiscifolius Marchand leaves

Andrade, Catalina Vanegas; Matera, Soledad Inés; Bayley, Matías; Colareda, Germán A.; Ruiz, María Esperanza; Prieto, Julián; Retta, Daiana; Baren, Catalina M. van; Consolini, Alicia E.; Ragone, María Inés

doi:10.1016/j.jtcme.2021.07.004

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…According to the physiological position from top to bottom, the upper end was connected to the tension transducer, and the lower end was fxed to the L-shaped bent hook at the bottom of the muscle groove. Each intestine segment was suspended in organ baths containing constantly oxygenated Tyrode's solution (20 mL, pH 8.2) at a constant temperature (37 °C ± 0.5 °C) [30]. Fresh oxygen was continuously introduced at a rate of 1-2 bubbles per second.…”

Section: Isolated Rat Intestine Preparationmentioning

confidence: 99%

Quantitative Analysis of the Multicomponent and Spectrum–Effect Correlation of the Antispasmodic Activity of Shaoyao-Gancao Decoction

Xü

Chen

et al. 2022

Journal of Analytical Methods in Chemistry

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Shaoyao-Gancao Decoction (SGD) is a well-known classic traditional Chinese medicine (TCM) with antispasmodic, anti-inflammatory, and analgesic effects. This preparation has been widely used to treat spasticity diseases in the clinic. To date, the material basis of SGD remains unclear, and the spectrum-effect correlation of its antispasmodic activity has not been reported yet. In this study, high-performance liquid chromatography (HPLC) was used to establish the fingerprint and determine the multiple components of SGD. The common peaks of fingerprints were evaluated by the similarity with the chromatographic fingerprints of the TCM. Meanwhile, the multiple components were quantified and analysed using the heatmap and box size analysis. Furthermore, data on the antispasmodic effect were extracted through in vitro smooth muscle contraction assay. Grey relational analysis combined with partial least square regression was used to study the spectrum–effect correlation of SGD. Finally, the potential antispasmolytic components were validated using an isolated tissue experiment. The HPLC fingerprint was established, and 20 common peaks were identified. The similarities of 15 batches of SGD were all above 0.965. The HPLC method for simultaneous determination of the multiple components was accurate and reliable. The contents of albiflorin, paeoniflorin, liquiritin, and glycyrrhizic acid were higher than the other components in SGD. The heatmap and box size also showed that X3 (albiflorin), X4 (paeoniflorin), X5 (liquiritin), X11 (liquirtigenin), and X16 (glycyrrhizic acid) could be used as quality indicators in the further establishment of quality standards. The spectrum–effect correlation results indicated that X4, X11, and X16 were highly correlated with antispasmolytic activity. Verification tests showed that paeoniflorin (11.7–29.25 μg/mL) and liquirtigenin (17.19–28.65 μg/mL) could significantly reduce the maximum contractile ( P < 0.01 ). These compounds exerted concentration-dependent spasmolytic effects with the inhibitory response for acetylcholine (Ach)-evoked contraction. Thus, SGD had a significant antispasmodic effect, which resulted from the synergistic activity of its multiple components. These findings can be used for the pharmacodynamics study of SGD and are of great significance for the determination of quality markers and quality control.

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Section: Isolated Rat Intestine Preparationmentioning

confidence: 99%

Quantitative Analysis of the Multicomponent and Spectrum–Effect Correlation of the Antispasmodic Activity of Shaoyao-Gancao Decoction

Xü

Chen

et al. 2022

Journal of Analytical Methods in Chemistry

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“…The results indicated that plant extract possesses strong anti-inflammatory (extract: 25% and diclofenac: 31%), antianalgesic (extract: 60% and Spasfon: 83%), and healing (extract: 7 days and madecassol: 9 days) properties when compared with the control [ 109 ]. The detailed investigation on antispasmodic, antidepressant, and anxiolytic effects of medicinal plant ( Schinus lentiscifolius ) from Argentina has been documented [ 110 ]. The plant bioactive compound ( S. lentiscifolius tincture) displayed concentration-dependent antispasmodic activity in intestinal muscle (IC 50 : 6.32 mg SchT/mL), bladder (IC 50 : 2.63 mg SchT/mL), and uterus (IC 50 : 4.05 mg SchT/mL) with a noncompetitive antagonism on the cholinergic contraction [ 110 ].…”

Section: Current Updates: At a Glancementioning

confidence: 99%

“…The detailed investigation on antispasmodic, antidepressant, and anxiolytic effects of medicinal plant ( Schinus lentiscifolius ) from Argentina has been documented [ 110 ]. The plant bioactive compound ( S. lentiscifolius tincture) displayed concentration-dependent antispasmodic activity in intestinal muscle (IC 50 : 6.32 mg SchT/mL), bladder (IC 50 : 2.63 mg SchT/mL), and uterus (IC 50 : 4.05 mg SchT/mL) with a noncompetitive antagonism on the cholinergic contraction [ 110 ].…”

Section: Current Updates: At a Glancementioning

confidence: 99%

Antispasmodic Potential of Medicinal Plants: A Comprehensive Review

Rauf

Akram

Semwal

et al. 2021

Oxidative Medicine and Cellular Longevity

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Numerous medicinal plants have been utilized for the treatment of different types of diseases and disorders including gastrointestinal (GI) diseases. GI diseases are the most common complaints that normally affects the largest proportion of children and adolescents with overlapping clinical manifestation in diagnosis and medical needs. Drugs with antispasmodic effects are normally applied for the symptomatic treatment of contraction and cramping of smooth muscles in gastrointestinal diseases as well as in other critical clinical situations. In alternative system of medicines, the antispasmodic herbs played a significant role in the cure of GI diseases. These medicinal plants and their herbal products are used from generation to generation because of multiple nutritional and therapeutic benefits. The multiple uses might be attributed to the presence on biologically active chemical constitutes. The main aim of this review is to focus on the medicinal potential of plants possessing antispasmodic activities with their proposed mechanism of action. Several databases such as Google Scholar, Cochrane database, Scopus, and PubMed were used to search the relevant literature regarding “plants with antispasmodic activities.” This present study highlights the updated and quantified information on several medicinal plants with antispasmodic activity like Zanthoxylum armatum, Matricaria chamomilla, Foeniculum vulgare, Pycnocycla spinosa, Atropa belladonna, Lavandula angustifolia, Mentha pulegium, Glycyrrhiza ularensis, Anethum graveolens, and Origanum majorana. Moreover, recent studies on other medicinal plant species also have been included in this review article. Additionally, the study also revealed that the active compounds of all these plants possess significant spasmolytic effect which is safest, efficacious, and cost effective as compared to the available synthetic drugs.

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Antidepressant Effects of Essential Oils: A Review of the Past Decade (2012–2022) and Molecular Docking Study of Their Major Chemical Components

Fonseca

Ferreira

Figueiredo

et al. 2023

IJMS

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Depression is a mental disorder that affects more than 300 million people worldwide. The medications available for treatment take a long time to exhibit therapeutic results and present several side effects. Furthermore, there is a decrease in the quality of life of people suffering from this affliction. Essential oils are traditionally used to relieve the symptoms of depression due to the properties of the constituents of these oils to cross the blood–brain barrier acting on depression-related biological receptors associated with reduced toxicity and side effects. In addition, compared to traditional drugs, they have several administration forms. This review provides a comprehensive assessment of studies on plants whose essential oil has exhibit antidepressant activity in the past decade and the mechanism of action of the major components and models tested. An additional in silico study was conducted with the frequent compounds in the composition of these essential oils, providing a molecular approach to the mechanism of action that has been reported in the past decade. This review is valuable for the development of potential antidepressant medications in addition to providing a molecular approach to the antidepressant mechanism of action of the major volatile compounds that have been reported in the past decade.

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Antispasmodic, antidepressant and anxiolytic effects of extracts from Schinus lentiscifolius Marchand leaves

Cited by 3 publications

References 38 publications

Quantitative Analysis of the Multicomponent and Spectrum–Effect Correlation of the Antispasmodic Activity of Shaoyao-Gancao Decoction

Quantitative Analysis of the Multicomponent and Spectrum–Effect Correlation of the Antispasmodic Activity of Shaoyao-Gancao Decoction

Antispasmodic Potential of Medicinal Plants: A Comprehensive Review

Antidepressant Effects of Essential Oils: A Review of the Past Decade (2012–2022) and Molecular Docking Study of Their Major Chemical Components

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