Antisolvent crystallization in porous hollow fiber devices

Analysis of nucleation kinetics of poorly water-soluble drugs in presence of ultrasound and hydroxypropyl methyl cellulose during antisolvent precipitation

“…(11) (Zarkadas and Sirkar, 2006) as MSMPR model does not fit well to the population densities calculated (as can be seen from Figs. 1 and 2).…”

Technical viability and exergy analysis of membrane crystallization: Closing the loop of CO2 sequestration

“…In addition, the main advantages of membrane crystallization have been already demonstrated: 1) it is possible to control the maximum level of supersaturation due to a defined mass transfer through the membrane [29]; 2) the membrane induces heterogeneous nucleation; 3) size, shape and purity of crystals can be controlled; 4) there is a significant reduction of energy consumption compared to conventional crystallization by means of cooling or evaporation [30]; and 5) comparable or slightly higher nucleation rates with respect to batch crystallizers or tubular precipitators have been obtained [24]. Furthermore, the use of membranes has been already considered to satisfy the requirements established by the "process intensification" strategy [31][32][33].…”

“…Crystallization of ionic salts [18][19][20], metal ions [21], low molecular organic acids [22][23], proteins and pharmaceutical compounds [24][25][26][27][28] are examples of the applicability of this technology. In addition, the main advantages of membrane crystallization have been already demonstrated: 1) it is possible to control the maximum level of supersaturation due to a defined mass transfer through the membrane [29]; 2) the membrane induces heterogeneous nucleation; 3) size, shape and purity of crystals can be controlled; 4) there is a significant reduction of energy consumption compared to conventional crystallization by means of cooling or evaporation [30]; and 5) comparable or slightly higher nucleation rates with respect to batch crystallizers or tubular precipitators have been obtained [24].…”

Precipitation of barium sulphate in a hollow fiber membrane contactor: Part II The influence of process parameters

“…An advantage of the hollow fiber membrane device is its scale-up ability (Zarkadas and Sirkar, 2006;Charcosset and Fessi, 2005). The flow rates can be easily increased by adding more fibers or using devices in parallel, to achieve the desired conversion rates and productivity (Kieffer et al, 2008).…”