Antiseptic povidone-iodine encapsulating edible phospholipid gels

Bayer, Gözde; Grasselli, Silvia; Malchiodi, Annalisa; Bayer, Ilker S.

doi:10.1016/j.colsurfa.2021.126537

Cited by 10 publications

(8 citation statements)

References 65 publications

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“…A series of organogels have been developed and classified based on the nature of organogelators such as lecithin organogels (LOs) [ 9 ]. Organogels or LOs could replace solid/hydrogenated fats in the food industry, transfer hydrophobic bioactive substances, nutritional drugs, or model bioactive compounds with medicinal or cosmetic interest [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

A Relation between Exopolysaccharide from Lactic Acid Bacteria and Properties of Fermentation Induced Soybean Protein Gels

et al. 2021

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Exopolysaccharide (EPS) producing lactic acid bacteria (LAB) is considered to be an effective texture improver. The effect of LAB strains (different EPS production capacity) on physicochemical properties (texture profile, water distribution, rheological properties, and microstructure), protein conformation, and chemical forces of soybean protein gel was investigated. Correlations between EPS yield and gel properties were established. Large masses of EPS were isolated from L. casei fermentation gel (L. casei-G, 677.01 ± 19.82 mg/kg). Gel with the highest hardness (319.74 ± 9.98 g) and water holding capacity (WHC, 87.74 ± 2.00%) was also formed with L. casei. The conversion of β-sheet to α-helix, the increased hydrophobic interaction and ionic bond helped to form an ordered gel network. The yield was positively correlated with hardness, WHC, A22, viscoelasticity, and viscosity, but negatively correlated with A23 (p < 0.05). The macromolecular properties of EPS (especially the yield) and its incompatibility with proteins could be explained as the main reason for improving gel properties. In conclusion, the EPS producing LAB, especially L. casei used in our study, is the best ordinary coagulate replacement in soybean-based products.

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Section: Introductionmentioning

confidence: 99%

A Relation between Exopolysaccharide from Lactic Acid Bacteria and Properties of Fermentation Induced Soybean Protein Gels

et al. 2021

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“…[26] The technology and material systems of hydrogels have evolved significantly so far that led to many different multifunctional hydrogels in the form of polymer blends, nanocomposites, nanofibers, protein, and DNA-based hydrogels. [209][210][211][212][213] Any hydrogel system developed for mucosal drug delivery or therapeutic applications should be studied thoroughly for mucoadhesive strength by using promising techniques such as methods based on an in vivo-like situation that usually calls for measuring the contact time or the force required to separate the formulation from a mucosal tissue. [214] Another promising method for hydrogel mucoadhesion is the detachment-force method that is integrated into tensile adhesion tests where the hydrogel is brought into contact with a mucosal tissue and the force or the work that is required to break the adhesive bond is measured.…”

Section: Future Perspectivesmentioning

confidence: 99%

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

Bayer

2022

Adv Materials Inter

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Mucoadhesion is an extremely important field of adhesion science and the comprehensive understanding and modulation of mucoadhesion can lead to lifesaving materials and technologies. For instance, deadly cases of COVID‐19 (SARS‐CoV‐2) cytokine storm are associated with viral adhesion and overproduction of mucus, which obstructs the airways. Mucin is the key polymeric compound that is known as a family of high molecular weight, heavily glycosylated proteins in epithelial tissues. Mucoadhesion can occur in many different ways such as receptor specific and charge interactions, covalent or noncovalent bonds. New mucin‐mimic polymers that replicate its beneficial traits can prevent biofilm formation and biofouling not only in biotechnology but also in membrane technologies. This review addresses the latest understandings related to mucin's role in wet adhesion considering different physiological conditions and shows how this translates into interfacial polymer adhesion. Advances in mucoadhesion measurement techniques including the rheological aspects of polymer–mucin adhesive interactions are presented. Specific mucoadhesive systems are discussed such as hydrogel mucoadhesion, catechol/dopamine functionalization, and polymeric nanoparticles. This overview may expand the current understanding of mucoadhesion between soft materials but also contributes to elastocapillary phenomena in soft materials design and applications such as new membranes, drugs, pharmaceutical devices, and lubricated surfaces.

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“…As discussed in previous reports, the characterizations of not only pure fibrin fiber mechanical properties, but also biomedical materials that contain fibrin fibers such as films, gels, or hydrogels and mucoadhesives, are equally important for the longevity of wound treatment and drug release [ 38 , 91 , 162 , 163 , 164 , 165 ]. The importance of mechanical properties of materials for chronic wound care has recently been acknowledged as vital for the biochemical function of these materials [ 166 ].…”

Section: On the Mechanical Properties Of Fibrin Fibersmentioning

confidence: 99%

Advances in Fibrin-Based Materials in Wound Repair: A Review

Bayer

2022

Molecules

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The first bioprocess that occurs in response to wounding is the deterrence of local hemorrhage. This is accomplished by platelet aggregation and initiation of the hemostasis cascade. The resulting blood clot immediately enables the cessation of bleeding and then functions as a provisional matrix for wound healing, which begins a few days after injury. Here, fibrinogen and fibrin fibers are the key players, because they literally serve as scaffolds for tissue regeneration and promote the migration of cells, as well as the ingrowth of tissues. Fibrin is also an important modulator of healing and a host defense system against microbes that effectively maintains incoming leukocytes and acts as reservoir for growth factors. This review presents recent advances in the understanding and applications of fibrin and fibrin-fiber-incorporated biomedical materials applied to wound healing and subsequent tissue repair. It also discusses how fibrin-based materials function through several wound healing stages including physical barrier formation, the entrapment of bacteria, drug and cell delivery, and eventual degradation. Pure fibrin is not mechanically strong and stable enough to act as a singular wound repair material. To alleviate this problem, this paper will demonstrate recent advances in the modification of fibrin with next-generation materials exhibiting enhanced stability and medical efficacy, along with a detailed look at the mechanical properties of fibrin and fibrin-laden materials. Specifically, fibrin-based nanocomposites and their role in wound repair, sustained drug release, cell delivery to wound sites, skin reconstruction, and biomedical applications of drug-loaded fibrin-based materials will be demonstrated and discussed.

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Antiseptic povidone-iodine encapsulating edible phospholipid gels

Cited by 10 publications

References 65 publications

A Relation between Exopolysaccharide from Lactic Acid Bacteria and Properties of Fermentation Induced Soybean Protein Gels

A Relation between Exopolysaccharide from Lactic Acid Bacteria and Properties of Fermentation Induced Soybean Protein Gels

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

Advances in Fibrin-Based Materials in Wound Repair: A Review

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