Antiseizure medication nonadherence and its associated factors among Epileptic patients in Ethiopia, a systematic review and meta-analysis

Amha, Haile; Memiah, Peter; Getnet, Asmamaw; Mengist, Belayneh; Gedfew, Mihretie; Ayenew, Temesgen; Akalu, Tadesse Yirga; Mulugeta, Henok; Bewket, Bekalu; Kebede, Bekalu; Petrucka, Pammla

doi:10.1016/j.seizure.2021.07.024

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…In accordance with this study nding, the low medication adherence among patients with comorbidity was found to be 36.389 times more likely to low adherence of AED when compared to those patients who had no comorbidity. The relationship between comorbidity and AED adherence was also shown in similar studies done in Aksum, Ethiopia, and Pakistan [31,33,34]. This could be explained that patients with comorbidity are more likely to have multiple drugs.…”

Section: Discussionsupporting

confidence: 61%

Assessment of Low and Medium Anti-epileptic Medication Adherence among Epileptic Patients in Dessie Comprehensive Specialized Hospital, North-East Ethiopia: Cross Sectional Study

Fissha

Kibret

Haile

2022

Preprint

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Background Non-adherence to anti-seizure medication therapy is an important contributing factor to the higher mortality rate and treatment failure of epilepsy. Complete antiepileptic therapy is an essential intervention aimed at improving the quality of life of patients who suffer from a disease which is known for its stigmatization with many cultural misconceptions. So the aim of this study was to assess low and medium anti-epileptic medication adherence among epileptic patients in Dessie comprehensive specialized hospital, north-east Ethiopia. Method A cross sectional study design was conducted among the epileptic patient attending Dessie comprehensive specialized hospital from May 4 to August 4, 2022, on the total sample size of 253 selected epileptic patients by using convenient sampling technique. Data was collected by using structured interview-administered quastitionary; its quality was checked by pretest and continuous supervision. Data was entered into Epi-data 3.1 version and exported to SPSS version 23 for analysis. Multivariable multinomial logistic regression model was used to determine the relationship between the independent variable and the outcome variable. Relative risk ratio (RRR) with 95% confidence interval was used at p value less than 0.05 to declare statistical significance association. Result From 253 study participants, this study found a 20.2%, and 30.8% incidence of the low and medium anti-epileptic drug adherence respectively. The factors for low anti-epileptic drug adherence were seizure since last visit (RRR = 1.033, 95% CI, (1.005–1.219), comorbidity of patient (RRR = 36.389, 95% CI, (7.198-183.963), adverse effect experiences since last visit (RRR = 3.938, 95% CI, (1.065–14.565), and duration of drug (RRR = 56.745, 95% CI, (.903-3567.210). The factors for medium anti-epileptic drug adherence were seizure since last visit (RRR = (1.305, 95% CI, (1.101–1.920), occupation status of the patient (RRR 1.008, 95% CI, (1.01–1.156), rural residents (RRR = 1.031, 95% CI, (1.008–1.120), and age category 18–27 (RRR = .161, 95% CI, (.031-.835). Conclusion The prevalence of low and medium antiepileptic drug adherence was high in this study. Health care providers should provide health education and medication related counseling for all patients with epilepsy to improve adherence.

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Section: Discussionsupporting

confidence: 61%

Assessment of Low and Medium Anti-epileptic Medication Adherence among Epileptic Patients in Dessie Comprehensive Specialized Hospital, North-East Ethiopia: Cross Sectional Study

Fissha

Kibret

Haile

2022

Preprint

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“…27,28 For example, in our study, we found 28 duplicates on various topics: two duplicates of SR and MA on mother-to-child transmission of HIV 29,30 , two on HIV/AIDS treatment failure 31,32 , three on nursing process 33-35 , three on antenatal depression 36-38 , three on postnatal depression 39-41 , three on breastfeeding 42-44 , three on immunization coverage 45-47 , three on low birth weight 48-50 , two on tuberculosis treatment non-adherence 51,52 , two on maternal-near miss 53,54 and two on antiepleptive medication non-adherence. 55,56 To minimize research waste, authors must register their protocol, thoroughly search protocol registration cites and communicate each other whenever possible. This can also increase collaboration and save energy and time.…”

Section: Discussionmentioning

confidence: 99%

Current status of methodological and reporting quality of systematic reviews and meta-analyses in medicine and health science fields in Ethiopia: Leveraging quantity to improve quality

Sharew

Endalamaw

Mulugeta

et al. 2022

Preprint

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IntroductionWith a rising publication rate of medicine and health sciences systematic reviews (SR) and meta-analyses (MA) in Ethiopia, there is a growing concern over their methodological and reporting quality. The aim of this study was to characterize epidemiological trends and evaluate the methodological and reporting quality of SR and MA Ethiopia.MethodsA retrospective observational overview study was conducted on medicine and health sciences SR and MA in Ethiopia that accessed through PubMed, PsycInfo, EMBASE databases and additional manual searching. SR and MA based on primary human studies associated with the Ethiopian population irrespective of the place of publication and authors’ affiliation and published until March 16, 2021 were included. Title/abstract and full-text screening were conducted in duplicate using EndNote and Covidence semiautometed reference management tools. Data extraction tool was developed by the author using PRISMA and AMSTAR-2 as a guide. We summarized background characteristics, and methodological and reporting qualities using frequencies with percentages and median with range. Two-tailed Chi-Square and Fisher’s Exact tests used for catergorical variables and Kruskal-Walis test for quantitative variables at alpha level 0.05 were used to compare the difference in background characterstics between SR and MA as well as across the publication years over time. All the analysis was done using R version 4.0.2 for macOS.ResultsOf the 3,125 total records initially identified, 349 articles (48 (13.75%) SR, and 301 (86.25%) MA) were included in our analyses. We observed a dramatic increase in publications with nearly three-quarters of SR and MA (73.9%) published after 2018. More than nine out of ten (92.8%) SR and MA included only observational studies and infectious disease, was the most researched (20.9%) subject area. Number of authors, number of affiliations, publication year, protocol registration, number of primary studies, number of references, citation counts and journal quality were significantly different between SR and MA. Both SR and MA had a low methodological and reporting quality Even though there was improvement in registering protocols, searching databases, and transparently reporting search strategy.ConclusionsThe production of SR and MA in Ethiopia has been increased over time, especially during the last three years. There is a promising trend of improvement in methodological and reporting quality even though there is much more to do. This study provide an up-to-date overview of the landscape of SR and MA publication rate and quality leverage in Ethiopia. Authors should prioritize quality over fast track publication.

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“…26,27 For example, we found 28 duplicates on various topics: two on mother-to-child transmission of HIV 28,29 , two on HIV/AIDS treatment failure 30,31 , three on nursing process [32][33][34] , three on antenatal depression [35][36][37] , three on postnatal depression [38][39][40] , three on breastfeeding [41][42][43] , three on immunization coverage [44][45][46] , three on low birth weight [47][48][49] , two on tuberculosis treatment non-adherence 50,51 , two on maternal-near miss 52,53 and two on antiepleptive medication non-adherence. 54,55 To minimize research waste, authors must register their protocol, thoroughly search protocol registration cites and communicate each other whenever possible. This can also increase collaboration and save energy and time.…”

Section: Declarationsmentioning

confidence: 99%

Methodological and reporting quality of systematic reviews and meta-analyses in medicine and health science fields in Ethiopia: Leveraging quantity to improve quality

Sharew

Endalamaw

Mulugeta

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Background Despite the rise in the number of systematic reviews (SR) and meta-analyses (MA) in medicine and health science fields in Ethiopia, there is limited up-to-date evidence on their methodological and reporting quality for using them in decision-making. The aim of this study was to characterize epidemiological trends and evaluate the methodological and reporting quality of SR and MA in Ethiopia. Methods A retrospective observational overview study was conducted on SR and MA in medicine and health science fields in Ethiopia that were accessed through PubMed, PsycINFO, EMBASE, CINAHL databases and additional manual searching. Title/abstract and full-text screening were conducted in duplicate using EndNote and Covidence semi-automated reference management tools. Data extraction tool was developed in consultation with standard guidelines. We summarized the data using frequencies and median. Two-tailed Chi-Square and Fisher’s Exact tests for categorical variables, while Kruskal-Wallis test for quantitative variables, were used at alpha level 0.05 to compare the differences in the background characteristics of SR and MA as well as across the publication years. All analyses were done using R version 4.0.2 for macOS. Results Of the total 3,125 records initially identified, 349 articles were included in our analyses. Of these, 48 (13.75%) were SR and 301 (86.25%) were MA. The publication rate was dramatically increased with nearly three-quarters (73.9%) of SR and MA published after 2018. Most of the SR and MA included observational studies (92.8%), and infectious disease was the most researched (20.9%) subject area. Number of authors, number of affiliations, publication year, protocol registration, number of primary studies, number of references, citation counts and journal quality were significantly different between SR and MA (p < 0.05). Both SR and MA had a low methodological and reporting quality even though there were improvements in registering protocols, searching databases, and transparently reporting search strategy. Conclusions The production of SR and MA in Ethiopia has been increased over time, especially during the last three years. There is a promising trend of improvement in methodological and reporting quality even though there is much more to do. Authors should equally prioritize quality in addition to the fast-track publication.

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Antiseizure medication nonadherence and its associated factors among Epileptic patients in Ethiopia, a systematic review and meta-analysis

Cited by 6 publications

References 36 publications

Assessment of Low and Medium Anti-epileptic Medication Adherence among Epileptic Patients in Dessie Comprehensive Specialized Hospital, North-East Ethiopia: Cross Sectional Study

Assessment of Low and Medium Anti-epileptic Medication Adherence among Epileptic Patients in Dessie Comprehensive Specialized Hospital, North-East Ethiopia: Cross Sectional Study

Current status of methodological and reporting quality of systematic reviews and meta-analyses in medicine and health science fields in Ethiopia: Leveraging quantity to improve quality

Methodological and reporting quality of systematic reviews and meta-analyses in medicine and health science fields in Ethiopia: Leveraging quantity to improve quality

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