Antischistosomal and Cytotoxic Effects of the Essential Oil of Tetradenia riparia (Lamiaceae)

Abstract

This paper reports on the antischistosomal and cytotoxic effects of the essential oil obtained from Tetradenia riparia leaves (TR-EO). At concentrations of 50 and 100 μg/mL, TR-EO killed all the worms after 120 and 24 h of incubation, respectively. At a concentration equal to or higher than 50 μg/mL, this oil also separated the coupled pairs and decreased the adult worm motor activity after incubation periods higher than 72 h. In addition, at 120 h of incubation, TR-EO slightly decreased the number of eggs produced by Schistosoma mansoni adult worms and significantly reduced the percentage of developed eggs, in a dose-dependent manner. XTT-colorimetric assays showed that the tested TR-EO concentrations were not considerably cytotoxic to V79 cells (IC50 = 253.5 μg/mL). The effects of TR-EO on egg development were noteworthy; therefore, this essential oil deserves further investigation to identify the chemical constituents that elicit activity against S. mansoni.

Chemical Composition of Essential Oil FromTetradenia ripariaand Its Attractant Activity for Mediterranean Fruit Fly,Ceratitis capitata

“…In another study, T. riparia leaf oil contained mainly fenchone (18.9%), followed by (E,E)-farnesol (17.7%) and aromadendrene oxide (17.3%). 30 These quantitative and qualitative differences between previous studies and our sample may be attributed to harvesting season, different geographic conditions, and environmental factors.…”

Chemical Composition, Antibacterial, Schistosomicidal, and Cytotoxic Activities of the Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae)

“…In this study, DA‐EO displays very promising schistosomicidal activity against Schistosoma mansoni adult worms in vitro , with LC 50 values of 6.50 ± 0.38, 3.66 ± 1.06, and 3.65 ± 0.76 μg/ml at 24, 48, and 72 h, respectively. Moreover, DA‐EO was much more active than other essential oils previously investigated by our research group, which only presented significant activity only at concentrations equal to or higher than 100 μg/ml . Monzote and co‐workers reported that the monoterpene ascaridole accounted for the antileishmanial effect of DA‐EO collected in Cuba, with a LC 50 = 0.1 ± 0.01 μg/ml.…”

Trypanocidal Activity of Dysphania ambrosioides, Lippia alba, and Tetradenia riparia Essential Oils against Trypanosoma cruzi

“…The chemical compositions of DA-EO and TR-EO resemble the chemical composition of EOs extracted from specimens of D. ambrosioides and T. riparia specimens collected in the same place years ago. [6,11] In the case of LA-EO, studies based on the EO composition have classified Lippia alba into two main chemotypes: the citral chemotype, rich in citral (a mixture of neral and geranial), and the linalool chemotype, which has high linalool content. [13,14] Data shown in Table 1 indicate that LA-EO was obtained from an L. alba linalool chemotype.…”

“…[8] Previous studies have shown that the EOs obtained from D. ambrosioides, L. alba, and T. riparia exert relevant biological activities in vitro, including action against T. cruzi, [4,9] Leishmania tarentolae, [10] and Schistosoma mansoni. [6,11] As part of our ongoing research into the parasitic actions of EOs, we have investigated the trypanocidal activity of the EOs obtained from D. ambrosioides (DA-EO), L. alba (LA-EO), and T. riparia (TR-EO) leaves collected in Brazil Southeastern against the T. cruzi trypomastigote and amastigote forms and their cytotoxicity to LLC-MK2 mammalian cells in vitro. This study also evaluates how intraperitoneal treatment with these EOs affects the acute CD murine model.…”