Antisaccade, clinical and motor executive functions in schizophrenia: Effects of 5HT2 antagonist; Cyproheptadine

Chaudhry, Imran B; Soni, Sujata; Hellewell, Jonathan S.E.; Deakin, J.F.W.

doi:10.1016/s0920-9964(97)82606-0

Cited by 2 publications

(1 citation statement)

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“…The relation between serotonergic activity and motor executive control has been another focus in attempts to understand the beneficial effects of the atypical agents on cognition. One study demonstrated that augmentation of conventional antipsychotic medication with the 5‐HT 2a/c antagonist cyproheptadine in 17 stable patients with schizophrenia resulted in significant improvement on standard executive function tests such as the Stroop, verbal fluency, and Trails B with no negative impact on symptoms (110). Extrapolating from this, it is possible that atypical antipsychotics with strong serotonergic modulation might be associated with improved cognitive function.…”

Section: Potential Mechanisms Of Cognitive Improvements With Atypicalmentioning

confidence: 99%

Cognitive effects of atypical antipsychotics: focus on bipolar spectrum disorders

MacQueen

Young

2003

Bipolar Disorders

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Studies examining cognitive dysfunction in bipolar disorder have documented neuropsychologic impairment in some patients. Recollection memory, attention, and visual information processing may be particularly impaired in patients with bipolar illness. Cognitive impairment appears to worsen with illness progression, and may have a significant impact on function. Pharmacotherapy to treat bipolar disorder including lithium, anticonvulsants, antidepressants, and atypical antipsychotics may have varying effects on cognitive functioning. Treatment with atypical antipsychotics has been associated with improvement in various cognitive measures in patients with schizophrenia, and the little data available in patients with bipolar disorder suggest the potential for similar benefits. Studies to determine if current treatments for bipolar disorder can prevent, delay, or even improve cognitive dysfunction are needed.

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Section: Potential Mechanisms Of Cognitive Improvements With Atypicalmentioning

confidence: 99%